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| LEADER |
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SCIDIR_ocn948792651 |
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OCoLC |
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20231120112054.0 |
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m o d |
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cr ||||||||||| |
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160112s2016 ne o 000 0 eng d |
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|a 941066746
|a 945612145
|a 957679742
|a 1229518117
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|a 9780128043301
|q (PDF ebook)
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|q (PDF ebook)
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|z 9780128042564
|q (pbk.)
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|z 0128042567
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|a (OCoLC)948792651
|z (OCoLC)941066746
|z (OCoLC)945612145
|z (OCoLC)957679742
|z (OCoLC)1229518117
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|a HEA
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|2 bisacsh
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4 |
|a 616.831
|2 23
|
| 100 |
1 |
|
|a D'Andrea, Michael R.
|q (Michael Robert),
|e author.
|
| 245 |
1 |
0 |
|a Intracellular consequences of amyloid in Alzheimer's disease /
|c Michael R. D'Andrea.
|
| 264 |
|
1 |
|a Amsterdam :
|b Academic Press,
|c 2016.
|
| 300 |
|
|
|a 1 online resource
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 588 |
0 |
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|a CIP data; item not viewed.
|
| 505 |
0 |
|
|a Front Cover; Intracellular Consequences of Amyloid in Alzheimer's Disease; Copyright Page; Dedication; Contents; About the Cover; About the Author; Preface; Acknowledgments; Introduction; References; 1 Amyloid Basis of Alzheimer's Disease; Historical Background of Amyloid and Plaques; Amyloid Generation and Processing; A? States; Detecting Intraneuronal Amyloid; APP/A?-Related Antibodies; Fixation and Pretreatment Factors; Summary; References; 2 Origin(s) of Intraneuronal Amyloid; A? From Within the Neuron; A? From Outside the Neuron; A? From Within the Brain; A? From Outside the Brain.
|
| 505 |
8 |
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|a Plasma A?Platelets; Epithelial Cells; The Blood-Brain Barrier; Entry of Extracellular A? Into the Neurons;?7 Receptors; Integrins and NMDA Receptors; Receptor for Advanced Glycosylation End Products; Apolipoprotein E; Summary; References; 3 Natural Intracellular Consequences of Amyloid; A? Functions in Normal Neurons; Neuronal Development; Viability; Arborization; Synaptic Physiology; Learning and Memory; BACE1-/- Mice; A? Functions in Other Cell Types; Fat Metabolism; Mitogenic, Cell Growth, and Migration Activity; Antimicrobial Activity; Intracellular Cargo Receptor; Wound Healing; Summary.
|
| 505 |
8 |
|
|a On Calcium SignalingOn Apoptosis; Morphological and Accumulating Levels Over Time; Summary; References; 5 Intraneuronal Amyloid and Plaque Formation; Models of Plaque Formation; Deposition-Based Models; Random Deposition Into the Parenchyma; Synaptic Deposition; Lytic Model; Intraneuronal A? Then Plaques; Characterizing Plaque Types: Does It Matter?; Relationship of Intraneuronal A?, Plaques, and Neurofibrillary Tangles; Summary; References; 6 Intraneuronal Amyloid and Cognitive Impairment; Intraneuronal A? to Cognition; Intracellular Levels.
|
| 505 |
8 |
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|a Correlation of A?-Induced Synaptic Changes With CognitionSummary; References; 7 Intraneuronal Amyloid and Inflammation; Efficacy of NSAIDs; Intraneuronal A?'s Role in Gliosis; Inflammatory Cells Exacerbate AD; Reactive Microglia; Activated Astrocytes; Summary; References; 8 Consequences of Intracellular Amyloid in Vascular System; AD as a Vascular Disease; Risk Factors; Cerebral Amyloid Angiopathy; Vascular Dementia; Type 2 Diabetes; Source of the Vascular-Ladened A?; Brain-Derived A?; Peripherally Derived A?; Locally Derived A?; Pathological Aspects of the BBB.
|
| 650 |
|
0 |
|a Alzheimer's disease
|x Pathophysiology.
|
| 650 |
|
0 |
|a Amyloid.
|
| 650 |
|
0 |
|a Alzheimer's disease.
|
| 650 |
|
2 |
|a Alzheimer Disease
|0 (DNLM)D000544
|
| 650 |
|
2 |
|a Amyloid
|0 (DNLM)D000682
|
| 650 |
|
6 |
|a Maladie d'Alzheimer
|0 (CaQQLa)201-0114128
|x Physiopathologie.
|0 (CaQQLa)201-0379296
|
| 650 |
|
6 |
|a Amylo�ide.
|0 (CaQQLa)201-0085294
|
| 650 |
|
6 |
|a Maladie d'Alzheimer.
|0 (CaQQLa)201-0114128
|
| 650 |
|
7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Internal Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a Alzheimer's disease.
|2 fast
|0 (OCoLC)fst00806532
|
| 650 |
|
7 |
|a Alzheimer's disease
|x Pathophysiology.
|2 fast
|0 (OCoLC)fst00806556
|
| 650 |
|
7 |
|a Amyloid.
|2 fast
|0 (OCoLC)fst00808151
|
| 776 |
0 |
8 |
|i Print version :
|z 9780128042564
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128042564
|z Texto completo
|
| 880 |
8 |
|
|6 505-00/(S
|a Plasma AβPlatelets; Epithelial Cells; The Blood-Brain Barrier; Entry of Extracellular Aβ Into the Neurons; α7 Receptors; Integrins and NMDA Receptors; Receptor for Advanced Glycosylation End Products; Apolipoprotein E; Summary; References; 3 Natural Intracellular Consequences of Amyloid; Aβ Functions in Normal Neurons; Neuronal Development; Viability; Arborization; Synaptic Physiology; Learning and Memory; BACE1-/- Mice; Aβ Functions in Other Cell Types; Fat Metabolism; Mitogenic, Cell Growth, and Migration Activity; Antimicrobial Activity; Intracellular Cargo Receptor; Wound Healing; Summary.
|
| 880 |
8 |
|
|6 505-00/(S
|a Correlation of Aβ-Induced Synaptic Changes With CognitionSummary; References; 7 Intraneuronal Amyloid and Inflammation; Efficacy of NSAIDs; Intraneuronal Aβ's Role in Gliosis; Inflammatory Cells Exacerbate AD; Reactive Microglia; Activated Astrocytes; Summary; References; 8 Consequences of Intracellular Amyloid in Vascular System; AD as a Vascular Disease; Risk Factors; Cerebral Amyloid Angiopathy; Vascular Dementia; Type 2 Diabetes; Source of the Vascular-Ladened Aβ; Brain-Derived Aβ; Peripherally Derived Aβ; Locally Derived Aβ; Pathological Aspects of the BBB.
|
| 880 |
8 |
|
|6 505-00/(S
|a On Calcium SignalingOn Apoptosis; Morphological and Accumulating Levels Over Time; Summary; References; 5 Intraneuronal Amyloid and Plaque Formation; Models of Plaque Formation; Deposition-Based Models; Random Deposition Into the Parenchyma; Synaptic Deposition; Lytic Model; Intraneuronal Aβ Then Plaques; Characterizing Plaque Types: Does It Matter?; Relationship of Intraneuronal Aβ, Plaques, and Neurofibrillary Tangles; Summary; References; 6 Intraneuronal Amyloid and Cognitive Impairment; Intraneuronal Aβ to Cognition; Intracellular Levels.
|
| 880 |
0 |
|
|6 505-00/(S
|a Front Cover; Intracellular Consequences of Amyloid in Alzheimer's Disease; Copyright Page; Dedication; Contents; About the Cover; About the Author; Preface; Acknowledgments; Introduction; References; 1 Amyloid Basis of Alzheimer's Disease; Historical Background of Amyloid and Plaques; Amyloid Generation and Processing; Aβ States; Detecting Intraneuronal Amyloid; APP/Aβ-Related Antibodies; Fixation and Pretreatment Factors; Summary; References; 2 Origin(s) of Intraneuronal Amyloid; Aβ From Within the Neuron; Aβ From Outside the Neuron; Aβ From Within the Brain; Aβ From Outside the Brain.
|
| 880 |
|
|
|6 504-00/(S
|a References4 Pathological Consequences of Aβ From Extracellular to Intraneuronal; Extracellular Aβ: The Amyloid Cascade Hypothesis; Genetic Support; APP Processing Mutations; Down Syndrome; Transgenic AD Preclinical Models; Mouse; Rat; Closing Comment; APOE ε4 Allele; Toxic Extracellular Aβ; Revised Hypothesis; Intracellular Aβ: Aβ's Last Stand; Inaccuracies in the Once Widely Accepted Amyloid Hypothesis; New Hypotheses; Intraneuronal Pathological Consequences of Intraneuronal Aβ; On Intermediate Filaments; On the Endolysosomal Pathway; On Chaperone Proteins; On Synapses; On Mitochondria.
|
