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SCIDIR_ocn948604261 |
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OCoLC |
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160503s2016 enka ob 001 0 eng d |
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|z (OCoLC)1229566504
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|a Advances in pathobiology and management of Paget's disease of bone /
|c edited by Sakamuri V. Reddy.
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| 264 |
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1 |
|a London, UK :
|b Academic Press is an imprint of Elsevier,
|c 2016.
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| 300 |
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|a 1 online resource :
|b illustrations
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
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|a Includes bibliographical references and index.
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0 |
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|a Online resource; title from PDF title page (ScienceDirect, viewed May 10, 2016).
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|a Front Cover; Advances in Pathobiology and Management of Paget's Disease of Bone; Copyright Page; Contents; List of Contributors; About the Editor; Preface; 1 Clinical Perspectives of Paget's Disease of Bone; Introduction; Natural History; Clinical Features and Complications; Diagnosis; Pathology; Biochemistry; Epidemiology; Secular Change in Paget's Disease; References; 2 Viral Etiology of Paget's Disease of Bone; Introduction; Paramyxo-Viral Etiology; Viral and Genetic Interactions; Acknowledgments; References; 3 Genetics of Paget's Disease of Bone; Introduction
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8 |
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|6 880-01
|a PDB: A Disorder of Protein Conformation?Acknowledgments; References; 7 Osteosarcoma in Paget's Disease of Bone; Introduction; Epidemiology; Clinical Presentation; Histopathology; Treatment and Prognosis; The Progression From Normal Bone to Paget's Disease to Pagetic Osteosarcoma; Genes Differentially Expressed in Paget's Disease and Pagetic Osteosarcoma; Acknowledgments; References; 8 Paget's Disease of Bone: Prognosis and Complications; Introduction; Prognosis of Paget's Disease of Bone; Morbidity and Quality of Life; Mortality; Impact of Pharmacological Treatment of PDB on the Prognosis
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|a Osteitis deformans.
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|a Osteitis deformans
|x Treatment.
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| 650 |
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2 |
|a Osteitis Deformans
|0 (DNLM)D010001
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| 650 |
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6 |
|a Maladie osseuse de Paget.
|0 (CaQQLa)201-0028051
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| 650 |
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6 |
|a Maladie osseuse de Paget
|0 (CaQQLa)201-0028051
|x Traitement.
|0 (CaQQLa)201-0377521
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|a MEDICAL
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|2 bisacsh
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| 650 |
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|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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| 650 |
|
7 |
|a Osteitis deformans
|2 fast
|0 (OCoLC)fst01048761
|
| 700 |
1 |
|
|a Reddy, Sakamuri V.,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Reddy, Sakamuri V.
|t Advances in Pathobiology and Management of Paget's Disease of Bone.
|d : Elsevier Science, �2016
|z 9780128050835
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128050835
|z Texto completo
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| 880 |
8 |
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|6 505-00/(S
|a Importance of Genetic FactorsSQSTM1; TNFRSF11B; VCP; Chromosome 1p13 Locus; Chromosome 7q33; Chromosome 8q24; Chromosome 10p13; Chromosome 14q32; Chromosome 15q24; Chromosome 18q21; Genetic Determinants of Disease Severity; Clinical Implications; References; 4 Developmental Aspects of Pagetic Osteoclasts; Introduction; Increased Sensitivity of OCL Progenitors to Osteotropic Factors; Increased Sensitivity to RANKL and TNFα; Increased Sensitivity to 1,25-(OH)2D3; Increased Nuclei/OCL; Increased Expression of IL-6; MVNP Activation of TBK1 Increases IL-6, OCL Formation, and Nuclei/OCL
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| 880 |
8 |
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|6 505-00/(S
|a MVNP Downregulation of FoxO3 and Sirt1 also Increase IL-6Increased Irregular Woven Bone Formation Induced by Pagetic OCL; EphrinB2/EphB4 Signaling; IGF1, FGF2, and CXCL5; Conclusion; Disclosures; References; 5 Mutant SQSTM1/p62 Signaling in Paget's Disease of Bone; Introduction; RANKL-Induced NFκB Signaling and Osteoclastogenesis; Defective NFκB Signaling Associated With Mutant SQSTM1/p62; SQSTM1/p62-Mediated RANKL-Induced AP-1, NFAT, and ERK Signaling; SQSTM1/p62-Mediated Regulation of Keap1/Nrf2 Signaling; SQSTM1/p62-Mediated Apoptosis; SQSTM1/p62-Mediated Autophagy
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| 880 |
8 |
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|6 505-01/(S
|a SQSTM1/p62 as a Signaling Hub Orchestrating the Interplay Between NFκB, Keap1 and AutophagyReferences; 6 Early Onset Pagetic Disorders: Implications for Late-Onset Paget's Disease of Bone; Introduction; Early-Onset Pagetic Syndromes; RANK; Juvenile Paget's Disease; Osteoprotegerin; Multisystem Proteinopathy; Valosin-containing protein; Molecular Mechanisms Leading to Early-Onset Pagetic Disorders and Relevance for Late-onset PDB; Classic PDB: Association With Genes Involved in RANK Signaling and/or Osteoclast Formation; Classic PDB: Genes Involved in Protein Degradation Pathways
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