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Controversies in diabetic neuropathy /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
|
| Colección: | International review of neurobiology ;
v. 127. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 020 | |z 9780128039151 |q (print) | ||
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| 082 | 0 | 4 | |a 616.4/62 |2 23 |
| 245 | 0 | 0 | |a Controversies in diabetic neuropathy / |c edited by Nigel A. Calcutt and Paul Femyhough. |
| 264 | 1 | |a Cambridge, MA : |b Academic Press is an imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a International review of neurobiology ; |v volume 127 | |
| 500 | |a Includes index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed May 9, 2016). | |
| 505 | 0 | |a Front Cover; Controversies In Diabetic Neuropathy; Copyright; Contents; Contributors; Preface; Section I: Clinical Context; Chapter One: A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy; References; Chapter Two: Neuropathy in the DCCT/EDIC-What Was Done Then and What We Would Do Better Now; 1. Introduction; 2. Neuropathy Outcomes Assessments; 2.1. DCCT and EDIC Design; 2.1.1. Assessment of DSPN in DCCT; 2.1.2. Assessment of DSPN in EDIC; 2.1.3. Additional DSPN Measures in EDIC; 2.1.4. Assessment of CAN in DCCT; 2.1.5. Assessment of CAN in EDIC | |
| 505 | 8 | |a 3. Complementary Assessments in EDIC3.1. Evaluation of Urologic Complications; 3.2. Gastroparesis; 3.3. Other Evaluations in EDIC; 4. DCCT/EDIC Findings; 4.1. DSPN and CAN Outcomes in the DCCT and EDIC Study; 5. Discussion; 5.1. DCCT/EDIC and Contemporary Neuropathy Trials Design; References; Chapter Three: The Perfect Clinical Trial; 1. Introduction; 2. Study Aims: Prevent DSP, Prevent Progression, or Reverse DSP?; 3. Selection of Study Participants; 4. Trial Duration; 5. Study End Points; 6. Core Labs and Training; 7. Intervention; 8. Study Conduct | |
| 505 | 8 | |a 9. Streamlined Ethics and Contracts Process10. Summary; References; Section II: New Models of Diabetic Neuropathy; Chapter Four: An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy; 1. Why Use Animal Models?; 2. What Species?; 3. What Diabetogenic Insult?; 4. STZ Toxicity; 5. Novel Models; References; Chapter Five: Can Diabetic Neuropathy Be Modeled In Vitro?; 1. Introduction; 2. Diabetic Neuropathy; 3. The Somatosensory Nervous System; 4. Can We Model Diabetic Neuropathy In Vitro?; 4.1. Choice of Cells; 4.1.1. Immortalized Cell Lines | |
| 505 | 8 | |a 4.1.2. Primary Tissue Culture4.1.3. Induced Pluripotent Stem Cells; 4.2. Choice of Stimuli; 4.3. Choice of Output Measure; 4.3.1. Life or Death?; 4.3.2. Altered Bioenergetics and Oxidative Stress; 4.3.3. Neuronal Hyperexcitability; 4.3.4. Axonal Degeneration and Regeneration; 4.4. Looking Forward to a Better In Vitro Model of Diabetic Neuropathy; 5. Conclusions; Acknowledgments; References; Chapter Six: Alternatives to the Streptozotocin-Diabetic Rodent; 1. Introduction; 2. Rodent Models of Obesity; 2.1. High-Fat Fed Sprague-Dawley Rats and C57Bl6/J Mice; 2.2. Zucker Rats | |
| 505 | 8 | |a 3. Rodent Models of Type 2 Diabetes3.1. Zucker Diabetic Fatty Rats; 3.2. Spontaneously Diabetic Torii Rat; 3.3. Zucker Diabetic Sprague-Dawley Rat; 3.4. Goto-Kakizaki Rat; 3.5. BioBreeding Zucker Diabetic Rat; 3.6. Otsuka Long-Evans Tokushima Fatty Rat; 3.7. Ob/ob and db/db Mice; 3.8. Tsumura Suzuki Obese Diabetes Mouse; 3.9. Combined High-Fat Fed, Low-Dose Streptozotocin Models of Type 2 Diabetes; 3.10. Streptozotocin-Nicotinamide Rat; 4. Rodent Models of Type 1 Diabetes; 4.1. Spontaneously Hypertensive Rat; 4.2. BioBreeding/Worcester Rat; 4.3. Ins2Akita Mouse; 4.4. Nonobese Diabetic Mouse | |
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 650 | 0 | |a Diabetic neuropathies. | |
| 650 | 2 | |a Diabetic Neuropathies |0 (DNLM)D003929 | |
| 650 | 6 | |a Neuropathies diab�etiques. |0 (CaQQLa)201-0010251 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Diabetic neuropathies. |2 fast |0 (OCoLC)fst00892230 | |
| 700 | 1 | |a Calcutt, Nigel A., |e editor. | |
| 700 | 1 | |a Fernyhough, Paul, |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Calcutt, Nigel. |t Controversies In Diabetic Neuropathy. |d : Elsevier Science, �2016 |z 9780128039151 |
| 830 | 0 | |a International review of neurobiology ; |v v. 127. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128039151 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00747742/127 |z Texto completo |