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Hematopoiesis /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
|
| Colección: | Current topics in developmental biology ;
v. 118. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Hematopoiesis; Copyright; Contents; Contributors; Preface; Chapter One: Regulation of Blood Stem Cell Development; 1. Introduction; 1.1. HSC Generation; 1.2. Tracking Hematopoietic Cell Generation from Embryonic Endothelium; 1.3. Regulation of Hemogenic Endothelium; 1.4. Hemogenic Transcriptional Program; 1.5. Reprogramming; References; Chapter Two: Hematopoietic Stem Cell and Its Bone Marrow Niche; 1. Introduction; 2. Evolution of the Stem Cell Niche Concept; 3. Location Matters; 4. Cellular Participants in the Bone Marrow Microenvironment; 4.1. Osteolineage Cells
- 4.2. Perivascular Cells4.3. Endothelial Cells; 4.4. Adipocytes; 4.5. Macrophages; 5. The Sympathetic Nervous System; 6. HSC Mobilization from the BM Niche; 7. Niche of Hematopoietic Malignancies; 8. Perspectives; References; Chapter Three: The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms; 1. cis-Regulatory Mechanisms; 2. GATA Factor Interactions with DNA and Chromatin; 2.1. Sequence Requirements; 2.2. Genomic and Bioinformatics Analysis; 2.3. Discovery and Validation of Enhancers Controlling HSPCs
- 3. Components of Scl/TAL1 and GATA Factor Complexes at E-box-GATA Elements3.1. LMO2; 3.2. LDB1; 3.3. KLF1; 3.4. SWI/SNF Chromatin-Remodeling Complex; 3.5. Single-Stranded DNA-Binding Proteins; 4. HSPC Cistrome; 5. Perspective; References; Chapter Four: ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development; 1. Introduction; 2. Etv2 Is Transiently Expressed in the Hemangiogenic Progenitors; 3. ETV2 Is Sufficient to Induce Hematopoietic and Endothelial Cell Formation; 4. Nonredundant and Transient Role of ETV2 in Hematopoietic and Endothelial Cell Formation
- 5. ETV2, VEGF, and FLK1 in Hematopoietic and Endothelial Cell Formation6. ETV2 Regulates Hemangiogenic versus Cardiac Mesoderm Outcome; 7. ETS Hierarchy and ETS Switching Mechanisms in Hematopoietic and Vascular Development; 8. ETV2 in Definitive Hematopoietic Program and Function; 9. Regulation of Etv2 Expression; 10. Closing Thoughts and Future Directions; Acknowledgments; References; Chapter Five: Taking the Leap: Runx1 in the Formation of Blood from Endothelium; 1. The Three Waves of Blood Cell Formation; 2. The Role of Runx1 in the Formation of Embryonic Progenitors and HSCs
- 3. The Temporal Requirement for Runx1 in Hemogenic Endothelium4. Downstream Runx1 Targets That Execute the Endothelial to Hematopoietic Cell Transition; 5. Epigenetic Regulation by Runx1; 6. Cis-Acting Sequences Regulating Runx1 Transcription; 7. The Gene Regulatory Network Upstream of Runx1; 8. Signaling Pathways Regulating Runx1 Expression in the Aorta; 8.1. Notch Signaling; 8.2. Fibroblast Growth Factor and Bone Morphogenic Protein Signaling; 9. Conclusions and Future Directions; References; Chapter Six: SCL/TAL1 in Hematopoiesis and Cellular Reprogramming; 1. Introduction