Advances in clinical chemistry. Volume 74 /

Advances in Clinical Chemistry, Volume 75, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. This serial discusses the latest and most up-to-date technologies related to t...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Makowski, Gregory S. (Gregory Stephen) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press is an imprint of Elsevier, 2016.
Temas:
Clinical chemistry.
Chemistry, Clinical
Chimie clinique.
MEDICAL > Diseases.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Clinical chemistry
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Capillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics; 1. Introduction; 2. CE-MS Methodology; 2.1. CE Modes and Separation Conditions; 2.2. Interfacing Aspects of CE-MS; 3. Clinical Metabolomics; 3.1. General Aspects; 3.2. Strategies for Data Analysis; 3.3. Applications; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Two: Metabolomics in Newborns; 1. Introduction; 2. Data Analysis in Metabolomics; 3. Metabolomics in Neonatology; 3.1. Prematurity
  • 3.2. Intrauterine Growth Retardation3.3. Inborn Errors of Metabolism; 3.4. Perinatal Asphyxia; 3.5. Sepsis; 3.6. Necrotizing Enterocolitis; 3.7. Kidney Disease; 3.8. Bronchopulmonary Dysplasia; 3.9. Cardiac Malformation and Dysfunction; 4. Conclusions; References; Chapter Three: Maternal Plasma DNA and RNA Sequencing for Prenatal Testing; 1. Introduction; 2. History; 2.1. Why Prenatal Screening for Aneuploidy?; 2.2. History of Invasive Prenatal Screening; 2.3. History of Noninvasive Prenatal Screening; 2.4. History of NIPT; 3. Background of NIPT
  • 4. Different Techniques and Bioinformatic Approaches4.1. The z-Score and Its Rationale to Determine Fetal Aneuploidies; 4.2. Whole-Genome Approach; 4.3. Targeted Approach; 4.4. Fetal Fraction Determination; 5. Biological Difficulties; 5.1. Reasons for False-Negative Results; 5.1.1. Low Fetal Fraction; 5.1.2. True Fetal Mosaicism; 5.1.3. Twin Pregnancies; 5.2. Reasons for False-Positive Results; 5.2.1. Confined Placental Mosaicism; 5.2.2. Maternal Findings: Chromosomal Abnormalities; 5.2.3. Maternal Findings: Malignancy; 5.2.4. Vanishing Twin; 6. Technical Difficulties
  • 7. Clinical Implementation7.1. Current Use of NIPT in a Diagnostic Setting; 7.2. Population-Based Screening; 7.3. Pretest Counseling; 7.4. Changes in Prenatal Diagnosis and Screening; 8. Ethical Aspects; 9. Professional Policy Statements; 10. Future Perspectives of Cell-free DNA Testing; 10.1. The Molecular Stethoscope; 10.2. Different Stores: Different Products on the Shelf; 10.3. Genome-Wide RNA Profiling in Pregnancy; 10.3.1. MicroRNA Profiling of Plasma in Pregnant Women; 10.3.2. Genome-Wide RNA Profiling of Plasma in Pregnant Women
  • 10.3.3. Genome-Wide RNA Profiling of Plasma of Pregnant Women with Preeclampsia10.4. Genome-Wide RNA Profiling of Circulating Platelets in Cancer: Consequences for Prenatal Testing; 11. Conclusions; Acknowledgments; References; Chapter Four: Tumor-Derived Exosomes and Their Role in Cancer Progression; 1. Introduction; 2. Exosome Biogenesis in Cancer; 3. Morphology and Molecular Content of Tumor-Derived Exosomes; 4. Communication of Tumor-Derived Exosomes with Their Cell Targets; 5. Biological Functions of Tumor-Derived Exosomes; 6. Methods Available for Studies of Tumor-Derived Exosomes

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