Advances in clinical chemistry. Volume 74 /

Advances in Clinical Chemistry, Volume 75, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. This serial discusses the latest and most up-to-date technologies related to t...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Makowski, Gregory S. (Gregory Stephen) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press is an imprint of Elsevier, 2016.
Temas:
Clinical chemistry.
Chemistry, Clinical
Chimie clinique.
MEDICAL > Diseases.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Clinical chemistry
Acceso en línea:Texto completo
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MARC

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245 0 0 |a Advances in clinical chemistry.  |n Volume 74 /  |c edited by Gregory S. Makowski. 
264 1 |a Cambridge, MA :  |b Academic Press is an imprint of Elsevier,  |c 2016. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
588 0 |a Online resource; title from PDF title page (ScienceDirect, viewed April 28, 2016). 
505 0 |a Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Capillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics; 1. Introduction; 2. CE-MS Methodology; 2.1. CE Modes and Separation Conditions; 2.2. Interfacing Aspects of CE-MS; 3. Clinical Metabolomics; 3.1. General Aspects; 3.2. Strategies for Data Analysis; 3.3. Applications; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Two: Metabolomics in Newborns; 1. Introduction; 2. Data Analysis in Metabolomics; 3. Metabolomics in Neonatology; 3.1. Prematurity 
505 8 |a 3.2. Intrauterine Growth Retardation3.3. Inborn Errors of Metabolism; 3.4. Perinatal Asphyxia; 3.5. Sepsis; 3.6. Necrotizing Enterocolitis; 3.7. Kidney Disease; 3.8. Bronchopulmonary Dysplasia; 3.9. Cardiac Malformation and Dysfunction; 4. Conclusions; References; Chapter Three: Maternal Plasma DNA and RNA Sequencing for Prenatal Testing; 1. Introduction; 2. History; 2.1. Why Prenatal Screening for Aneuploidy?; 2.2. History of Invasive Prenatal Screening; 2.3. History of Noninvasive Prenatal Screening; 2.4. History of NIPT; 3. Background of NIPT 
505 8 |a 4. Different Techniques and Bioinformatic Approaches4.1. The z-Score and Its Rationale to Determine Fetal Aneuploidies; 4.2. Whole-Genome Approach; 4.3. Targeted Approach; 4.4. Fetal Fraction Determination; 5. Biological Difficulties; 5.1. Reasons for False-Negative Results; 5.1.1. Low Fetal Fraction; 5.1.2. True Fetal Mosaicism; 5.1.3. Twin Pregnancies; 5.2. Reasons for False-Positive Results; 5.2.1. Confined Placental Mosaicism; 5.2.2. Maternal Findings: Chromosomal Abnormalities; 5.2.3. Maternal Findings: Malignancy; 5.2.4. Vanishing Twin; 6. Technical Difficulties 
505 8 |a 7. Clinical Implementation7.1. Current Use of NIPT in a Diagnostic Setting; 7.2. Population-Based Screening; 7.3. Pretest Counseling; 7.4. Changes in Prenatal Diagnosis and Screening; 8. Ethical Aspects; 9. Professional Policy Statements; 10. Future Perspectives of Cell-free DNA Testing; 10.1. The Molecular Stethoscope; 10.2. Different Stores: Different Products on the Shelf; 10.3. Genome-Wide RNA Profiling in Pregnancy; 10.3.1. MicroRNA Profiling of Plasma in Pregnant Women; 10.3.2. Genome-Wide RNA Profiling of Plasma in Pregnant Women 
505 8 |a 10.3.3. Genome-Wide RNA Profiling of Plasma of Pregnant Women with Preeclampsia10.4. Genome-Wide RNA Profiling of Circulating Platelets in Cancer: Consequences for Prenatal Testing; 11. Conclusions; Acknowledgments; References; Chapter Four: Tumor-Derived Exosomes and Their Role in Cancer Progression; 1. Introduction; 2. Exosome Biogenesis in Cancer; 3. Morphology and Molecular Content of Tumor-Derived Exosomes; 4. Communication of Tumor-Derived Exosomes with Their Cell Targets; 5. Biological Functions of Tumor-Derived Exosomes; 6. Methods Available for Studies of Tumor-Derived Exosomes 
520 3 |a Advances in Clinical Chemistry, Volume 75, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. This serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. 
650 0 |a Clinical chemistry. 
650 2 |a Chemistry, Clinical  |0 (DNLM)D002624 
650 6 |a Chimie clinique.  |0 (CaQQLa)201-0016714 
650 7 |a MEDICAL  |x Diseases.  |2 bisacsh 
650 7 |a HEALTH & FITNESS  |x Diseases  |x General.  |2 bisacsh 
650 7 |a MEDICAL  |x Clinical Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Evidence-Based Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Internal Medicine.  |2 bisacsh 
650 7 |a Clinical chemistry  |2 fast  |0 (OCoLC)fst00864330 
700 1 |a Makowski, Gregory S.  |q (Gregory Stephen),  |e editor. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780128046890  |z Texto completo 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/00652423/74  |z Texto completo 

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