Chelation therapy in the treatment of metal intoxication /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Aaseth, Jan
Otros Autores: Criponi, Guido, Andersen, Ole
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2016.
Temas:
Chelation therapy.
Chelation Therapy
Ch�elation (Th�erapeutique)
MEDICAL > Pharmacology.
Chelation therapy
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover; Title Page; Copyright Page; Contents; Contributors; Preface; List of Abbreviations; Chapter 1
  • General Chemistry of Metal Toxicity and Basis for Metal Complexation; 1.1
  • General chemistry of metals; 1.2
  • Essential and nonessential elements; 1.3
  • Effects of toxic exposure of an essential or nonessential metal; 1.3.1
  • Basic Concepts in Chemical Toxicity Testing; 1.3.2
  • Exposure Patterns and Mechanisms of Metal Toxicity; 1.3.3
  • Gastrointestinal Effects of Metal Exposure; 1.3.4
  • Respiratory Effects of Metal Exposure; 1.3.5
  • Hepatic and Renal Effects.
  • 1.3.6
  • Effects on the Nervous System1.3.7
  • Hematological Effects; 1.3.8
  • Cardiovascular Effects; 1.3.9
  • Metal Allergies; 1.3.10
  • Carcinogenic Effects; 1.4
  • Basis for metal complex formation with endogenous and exogenous ligands; 1.5
  • Endogenous complexing and detoxification compounds; 1.5.1
  • Albumin; 1.5.2
  • Transferrin and Ferritin; 1.5.3
  • Glutathione; 1.5.4
  • Metallothionein; 1.5.5
  • Selenoproteins; 1.6
  • Conclusions; References; Chapter 2
  • Chelating Agents as Therapeutic Compounds-Basic Principles; 2.1
  • Chemical and biological principles for in vivo chelation; 2.1.1
  • Stability.
  • 2.1.2
  • Selectivity2.1.3
  • Kinetic Aspects of Chelation; 2.1.4
  • Absorption and Bioavailability of Chelating Agents; 2.2
  • Chelating agents: chemistry, kinetics, and toxicology; 2.2.1
  • BAL, DMPS, DMSA; 2.2.2
  • D-penicillamine; 2.2.3
  • Triethylenetetramine; 2.2.4
  • Deferoxamine, Deferiprone, and Deferasirox; 2.2.5
  • EDTA and DTPA; 2.2.6
  • Prussian Blue; References; Chapter 3
  • Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy; 3.1
  • Introduction; 3.2
  • History of symptoms and exposure; 3.3
  • Clinical findings; 3.4
  • Genetic disorders with systemic metal accumulation.
  • 3.5
  • Toxicological analyses3.6
  • Biochemical measurements; 3.7
  • Physiological, radiological, and ultrasonographic investigations; References; Chapter 4
  • Chelation Treatment During Acute and Chronic Metal Overexposures-Experimental and Clinical Studies; 4.1
  • Introduction; 4.2
  • Aluminum; 4.2.1
  • Selected Representative Animal Studies; 4.2.2
  • Selected Representative Clinical Studies; 4.2.3
  • Conclusions; 4.3
  • Antimony; 4.3.1
  • Animal Experiments; 4.3.2
  • Clinical Cases; 4.3.3
  • Conclusion; 4.4
  • Arsenic; 4.4.1
  • Selected Animal Experiments; 4.4.2
  • Clinical Studies.
  • 4.4.3
  • Discussion and Conclusion4.5
  • Beryllium; 4.5.1
  • Experimental Chelation Studies; 4.5.2
  • Clinical Experience; 4.5.3
  • Conclusion; 4.6
  • Bismuth; 4.6.1
  • Animal Chelation Studies; 4.6.2
  • Clinical Chelation Studies; 4.6.3
  • Conclusion; 4.7
  • Cadmium; 4.7.1
  • Animal Chelation Experiments; 4.7.2
  • Clinical Chelation Studies; 4.7.3
  • Conclusion; 4.8
  • Chromium; 4.8.1
  • Animal Experimental Studies; 4.8.2
  • Clinical Cases; 4.8.3
  • Conclusion; 4.9
  • Cobalt; 4.9.1
  • Chelation, Animal Experiments; 4.9.2
  • Chelation, Clinical Studies; 4.9.3
  • Conclusion; 4.10
  • Copper.
  • 4.10.1
  • Animal Chelation Studies.

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