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Molecules to medicine with mTOR : translating critical pathways into novel therapeutic strategies /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier Science,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1 Novel Stem Cell Strategies with mTOR; 1.1 Life Expectancy and the Significance of Global Noncommunicable Diseases; 1.2 mTOR Structure and Signaling; 1.3 mTOR and Oxidative Cell Stress; 1.4 mTOR, Stem Cell Survival, Apoptosis, and Autophagy; 1.5 mTOR, Stem Cell Proliferation, and Stem Cell Differentiation; 1.6 mTOR, Stem Cells, and Metabolic Disease; 1.7 mTOR, Stem Cells, and the Nervous System.
- 1.8 mTOR, Stem Cells, and the Vascular System1.9 mTOR, Stem Cells, and Tumorigenesis; 1.10 Future Considerations; Acknowledgments; References; 2 mTOR: The Master Regulator of Conceptus Development in Response to Uterine Histotroph During Pregnancy in Ungulates; 2.1 Introduction; 2.2 Developmental Events of Ungulate Conceptus; 2.3 Role of mTOR as a Master Regulator of Cell Growth; 2.4 Histotroph and the mTOR Cell Signaling Pathway During Conceptus Development; 2.4.1 Arginine and mTOR; 2.4.2 Nitric Oxide and mTOR; 2.4.3 Polyamines and mTOR; 2.4.4 Leucine and mTOR; 2.4.5 Glutamine and mTOR.
- 2.4.6 Fructose and mTOR2.4.7 SPP1 and mTOR; 2.5 Summary; Acknowledgments; References; 3 mTORC1 in the Control of Myogenesis and Adult Skeletal Muscle Mass; 3.1 Skeletal Muscle-An Introduction; 3.2 The mTOR Signaling Pathway in Skeletal Muscle; 3.3 Skeletal Muscle Myogenesis-An Overview; 3.3.1 The Role of mTOR in Myogenesis; 3.3.1.1 Kinase-Independent mTOR Regulation of Myogenesis; 3.3.1.2 Kinase-Dependent mTOR Regulation of Myogenesis; 3.3.1.3 The Role of mTORC1 in Myogenesis; 3.4 Regulation of Adult Skeletal Muscle Mass; 3.4.1 mTORC1 Regulation of Muscle Mass in Response to Nutrients.
- 3.4.1.1 Protein-Amino Acids3.4.1.2 Carbohydrates and Fats-Glucose and FA; 3.4.2 mTORC1 Regulation of Muscle Mass in Response to Growth Factors; 3.4.2.1 Insulin; 3.4.2.2 Insulin-Like Growth Factor 1; 3.4.2.3 Testosterone; 3.4.3 mTORC1 Regulation of Muscle Mass in Response to Mechanical Load/Exercise; 3.4.3.1 Resistance Exercise/Training; 3.4.3.2 Regulation of mTORC1 Activity in Response to Mechanical Stimuli; 3.4.4 Coordination of mTORC1 Signaling by Multiple Stimuli in Skeletal Muscle; 3.4.4.1 Amino Acids and Growth Factors; 3.4.4.2 Amino Acids and Mechanical Load.
- 3.4.4.3 Growth Factors and Mechanical Load3.5 Outstanding Questions; 3.6 Summary; References; 4 mTOR: A Critical Mediator of Articular Cartilage Homeostasis; 4.1 Introduction; 4.2 Mechanistic Target of Rapamycin; 4.2.1 mTOR Structure; 4.2.2 mTOR Signaling Pathway; 4.2.3 Autophagy; 4.2.4 Cartilage Growth and Development: Role of mTOR; 4.2.5 Articular Cartilage Degeneration: Role of mTOR/Autophagy Signaling; 4.3 Conclusion; References; 5 The Role of mTOR, Autophagy, Apoptosis, and Oxidative Stress During Toxic Metal Injury; 5.1 Introduction; 5.2 Cellular Functions of mTOR.