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| 001 |
SCIDIR_ocn945612125 |
| 003 |
OCoLC |
| 005 |
20231120112054.0 |
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m o d |
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cr mn||||||||| |
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160402t20162016ne ob 001 0 eng d |
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|a 2015949255
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| 040 |
|
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|a EBLCP
|b eng
|e rda
|e pn
|c EBLCP
|d CDX
|d IDEBK
|d N$T
|d YDXCP
|d UIU
|d OPELS
|d OCLCF
|d OSU
|d OCLCQ
|d U3W
|d OCLCQ
|d D6H
|d WYU
|d OCLCA
|d MERER
|d OCLCO
|d OCLCA
|d OCLCQ
|d OCLCA
|d AU@
|d ERF
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|d OCLCO
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|a 101685377
|2 DNLM
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|a 941066748
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|a 1235822623
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|a 9780128027554
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|a 012802755X
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|z 9780128027332
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|z 0128027339
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|
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|a (OCoLC)945612125
|z (OCoLC)941066748
|z (OCoLC)1066442522
|z (OCoLC)1112548160
|z (OCoLC)1235822623
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4 |
|a RM373
|
| 060 |
0 |
0 |
|a 2016 F-067
|
| 060 |
1 |
0 |
|a QU 141
|
| 072 |
|
7 |
|a MED
|x 071000
|2 bisacsh
|
| 082 |
0 |
4 |
|a 615.3/7
|2 23
|
| 245 |
0 |
0 |
|a Molecules to medicine with mTOR :
|b translating critical pathways into novel therapeutic strategies /
|c edited by Kenneth Maiese.
|
| 264 |
|
1 |
|a Amsterdam :
|b Elsevier Science,
|c 2016.
|
| 264 |
|
4 |
|c �2016
|
| 300 |
|
|
|a 1 online resource (xvii, 454 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
|
| 504 |
|
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|a Includes bibliographical references and index.
|
| 505 |
0 |
|
|a 1 Novel Stem Cell Strategies with mTOR; 1.1 Life Expectancy and the Significance of Global Noncommunicable Diseases; 1.2 mTOR Structure and Signaling; 1.3 mTOR and Oxidative Cell Stress; 1.4 mTOR, Stem Cell Survival, Apoptosis, and Autophagy; 1.5 mTOR, Stem Cell Proliferation, and Stem Cell Differentiation; 1.6 mTOR, Stem Cells, and Metabolic Disease; 1.7 mTOR, Stem Cells, and the Nervous System.
|
| 505 |
8 |
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|a 1.8 mTOR, Stem Cells, and the Vascular System1.9 mTOR, Stem Cells, and Tumorigenesis; 1.10 Future Considerations; Acknowledgments; References; 2 mTOR: The Master Regulator of Conceptus Development in Response to Uterine Histotroph During Pregnancy in Ungulates; 2.1 Introduction; 2.2 Developmental Events of Ungulate Conceptus; 2.3 Role of mTOR as a Master Regulator of Cell Growth; 2.4 Histotroph and the mTOR Cell Signaling Pathway During Conceptus Development; 2.4.1 Arginine and mTOR; 2.4.2 Nitric Oxide and mTOR; 2.4.3 Polyamines and mTOR; 2.4.4 Leucine and mTOR; 2.4.5 Glutamine and mTOR.
|
| 505 |
8 |
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|a 2.4.6 Fructose and mTOR2.4.7 SPP1 and mTOR; 2.5 Summary; Acknowledgments; References; 3 mTORC1 in the Control of Myogenesis and Adult Skeletal Muscle Mass; 3.1 Skeletal Muscle-An Introduction; 3.2 The mTOR Signaling Pathway in Skeletal Muscle; 3.3 Skeletal Muscle Myogenesis-An Overview; 3.3.1 The Role of mTOR in Myogenesis; 3.3.1.1 Kinase-Independent mTOR Regulation of Myogenesis; 3.3.1.2 Kinase-Dependent mTOR Regulation of Myogenesis; 3.3.1.3 The Role of mTORC1 in Myogenesis; 3.4 Regulation of Adult Skeletal Muscle Mass; 3.4.1 mTORC1 Regulation of Muscle Mass in Response to Nutrients.
|
| 505 |
8 |
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|a 3.4.1.1 Protein-Amino Acids3.4.1.2 Carbohydrates and Fats-Glucose and FA; 3.4.2 mTORC1 Regulation of Muscle Mass in Response to Growth Factors; 3.4.2.1 Insulin; 3.4.2.2 Insulin-Like Growth Factor 1; 3.4.2.3 Testosterone; 3.4.3 mTORC1 Regulation of Muscle Mass in Response to Mechanical Load/Exercise; 3.4.3.1 Resistance Exercise/Training; 3.4.3.2 Regulation of mTORC1 Activity in Response to Mechanical Stimuli; 3.4.4 Coordination of mTORC1 Signaling by Multiple Stimuli in Skeletal Muscle; 3.4.4.1 Amino Acids and Growth Factors; 3.4.4.2 Amino Acids and Mechanical Load.
|
| 505 |
8 |
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|a 3.4.4.3 Growth Factors and Mechanical Load3.5 Outstanding Questions; 3.6 Summary; References; 4 mTOR: A Critical Mediator of Articular Cartilage Homeostasis; 4.1 Introduction; 4.2 Mechanistic Target of Rapamycin; 4.2.1 mTOR Structure; 4.2.2 mTOR Signaling Pathway; 4.2.3 Autophagy; 4.2.4 Cartilage Growth and Development: Role of mTOR; 4.2.5 Articular Cartilage Degeneration: Role of mTOR/Autophagy Signaling; 4.3 Conclusion; References; 5 The Role of mTOR, Autophagy, Apoptosis, and Oxidative Stress During Toxic Metal Injury; 5.1 Introduction; 5.2 Cellular Functions of mTOR.
|
| 500 |
|
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|a 5.3 Free Radicals in Cells.
|
| 588 |
0 |
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|a Print version record.
|
| 650 |
|
0 |
|a Rapamycin.
|
| 650 |
|
0 |
|a Cellular signal transduction.
|
| 650 |
|
0 |
|a Mammals.
|
| 650 |
1 |
2 |
|a TOR Serine-Threonine Kinases
|0 (DNLM)D058570
|
| 650 |
1 |
2 |
|a Sirolimus
|0 (DNLM)D020123
|
| 650 |
2 |
2 |
|a Signal Transduction
|0 (DNLM)D015398
|
| 650 |
2 |
2 |
|a Mammals
|0 (DNLM)D008322
|
| 650 |
|
6 |
|a Sirolimus.
|0 (CaQQLa)201-0363993
|
| 650 |
|
6 |
|a S�erine/thr�eonine kinases TOR.
|0 (CaQQLa)000299473
|
| 650 |
|
6 |
|a Transduction du signal cellulaire.
|0 (CaQQLa)201-0206812
|
| 650 |
|
6 |
|a Mammif�eres.
|0 (CaQQLa)201-0001359
|
| 650 |
|
7 |
|a Mammalia (class)
|2 aat
|0 (CStmoGRI)aat300265707
|
| 650 |
|
7 |
|a MEDICAL
|x Pharmacology.
|2 bisacsh
|
| 650 |
|
7 |
|a Mammals
|2 fast
|0 (OCoLC)fst01006948
|
| 650 |
|
7 |
|a Cellular signal transduction
|2 fast
|0 (OCoLC)fst00850288
|
| 650 |
|
7 |
|a Rapamycin
|2 fast
|0 (OCoLC)fst01089963
|
| 700 |
1 |
|
|a Maiese, Kenneth,
|d 1958-
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Maiese, Kenneth.
|t Molecules to Medicine with mTOR : Translating Critical Pathways into Novel Therapeutic Strategies.
|d : Elsevier Science, �2016
|z 9780128027332
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128027332
|z Texto completo
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128027332
|x StGlGCU
|z Texto completo
|
