Profiles of drug substances, excipients and related methodology. Volume forty one /

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Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceut...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brittain, H. G. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2016.
Edición:First edition.
Colección:Profiles of drug substances, excipients, and related methodology ; 41.
Temas:
Drugs.
Excipients.
Pharmaceutical Preparations
Pharmaceutical Vehicles
Excipients
M�edicaments.
MEDICAL > Pharmacology.
Drugs
Acceso en línea:Texto completo
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Tabla de Contenidos:
  • Front Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface to Volume 41; Chapter One: Bupropion Hydrochloride; 1. Description; 1.1. Nomenclature; 1.1.1. Systematic Chemical Name; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.2. Formula; 1.2.1. Empirical Formula, Molecular Weight, CAS Number; 1.2.2. Structural Formula; 1.2.3. Stereochemical Description; 1.3. Elemental Analysis; 1.4. Appearance (Smell, Documented Taste); 1.5. Uses and Applications; 2. Method of Preparation; 2.1. Synthesis; 3. Physical Properties
  • 3.1. Dissociation Constant3.2. Solubility; 3.3. pH; 3.4. Partition Coefficient; 3.5. Hygroscopicity; 3.6. Crystallographic Properties; 3.6.1. Polymorphism; 3.6.2. Single-Crystal Structures; 3.6.3. XRPD Pattern; 3.7. Thermal Analysis; 3.7.1. Melting Behavior; 3.7.2. Differential Scanning Calorimetry and Thermogravimetric Analysis; 3.8. Spectroscopy; 3.8.1. Electronic Spectroscopy; 3.8.1.1. UV/VIS Spectroscopy; 3.8.2. Vibrational Spectroscopy; 3.8.2.1. NIR; 3.8.2.2. Fourier Transform IR; 3.8.2.3. Raman; 3.8.3. Nuclear Magnetic Resonance Spectrometry; 3.8.3.1. 1H; 3.8.3.2. COSY; 3.8.3.3. NOESY
  • 3.8.3.4. 13C3.8.3.5. HSQC; 3.8.3.6. HMBC; 3.8.3.7. DEPT; 3.8.3.8. 13C Solid-State; 3.8.4. Mass Spectrum; 4. Methods of Analysis; 4.1. Electrochemical Analysis; 4.2. Chromatographic Analysis; 4.2.1. Thin Layer Chromatography; 4.2.2. Gas Chromatography; 4.2.3. High-Performance Liquid Chromatography; 4.2.4. Ultra Performance Liquid Chromatography; 5. Stability; 5.1. Solution Stability; 5.2. Solid-State Stability; 5.3. Stability in Biological Medium; 6. Biological Properties; 6.1. Toxicity; 6.2. Drug Metabolism and Pharmacokinetics; 6.2.1. Absorption; 6.2.2. Distribution; 6.2.3. Metabolism
  • 6.2.4. EliminationAcknowledgments; References; Chapter Two: Calcium Carbonate; 1. Description; 1.1. Nomenclature; 1.1.1. Systematic Chemical Names; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, Identification Numbers; 1.2.2. Structural Formula; 1.3. Elemental Analysis; 1.4. Appearance; 2. Methods of Preparation; 2.1. Existence in Nature; 2.2. Preparation of Crystalline Form; 2.2.1. Calcium Acetate and Carbon Dioxide; 2.2.2. Calcium Hydroxide and Carbon Dioxide; 2.2.3. Calcium Chloride and Sodium Bicarbonate
  • 2.2.4. Calcium Acetate and Ammonium Carbonate2.2.5. Calcium Chloride, Gelatin, and Urea; 2.2.6. Carbon Dioxide Sequestration; 2.2.7. Cockle Shell and Dodecyl Dimethyl Betaine; 2.2.8. Dolomite and Sucrose; 2.2.9. Quicklime or Hydrated Lime; 2.2.10. Wollastonite; 2.2.11. Dolomite; 2.2.12. Gypsum Waste; 2.3. Preparation of Amorphous Form; 2.3.1. Calcium Chloride and Sodium Carbonate; 2.3.2. Calcium Chloride and Dimethyl Carbonate; 2.3.3. Dolomitic Marble with the Aid of Poly(Acrylic Acid); 2.3.4. Calcium Hydroxide and Carbon Dioxide

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