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The molecular basis of drug addiction /
This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
[2016]
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| Colección: | Progress in molecular biology and translational science.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Cover; Title page; Copyright page ; Contents ; Contributors; Preface; Chapter One
- Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects ; Abstract; 1 Introduction; 2 ERK Signaling Pathway; 3 ERK Signaling and Drug Addiction; 3.1 Cocaine; 3.2 Amphetamine; 3.3 Methamphetamine; 3.4 Marijuana; 3.5 Nicotine; 3.6 Alcohol (Ethanol); 4 Conclusions and Future Directions; Acknowledgment; References; Chapter Two
- Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings ; Abstract; 1 Alcoholism and Genetics
- 2 Central Glutamatergic Activity2.1 Metabotropic Glutamate Receptors ; 2.2 Ionotropic Glutamate Receptors ; 2.3 Glutamate Transporters and Carriers ; 2.4 Glutamate Synthesis and Metabolism ; 2.5 Glutamate and the Postsynaptic Density ; 3 Central Glutamate Activity and Alcohol Dependence; 3.1 Alcohol's Effects on Glutamate Activity and Extracellular Levels; 3.2 Metabotropic Glutamate Receptors and Alcohol; 3.3 Ionotropic Glutamate Receptors and Alcohol; 3.4 Glutamate Transporters/Carriers and Alcohol; 3.5 Glutamate-Associated Enzyme Activity and Alcohol
- 3.6 The Postsynaptic Density and Alcohol4 Glutamate-Associated Genetic Variations and Alcoholism; 5 Alcohol and Glutamate Gene Expression; 6 Alcohol-Associated Changes in Gene/Protein Expression of P Rats; 6.1 Metabotropic Glutamate Receptor Expression Differences ; 6.2 Ionotropic Glutamate Receptor Expression Differences ; 6.3 Expression Differences for Glutamate Transporters, Enzymes, and Postsynaptic Density ; 7 Conclusions; Acknowledgments; References; Chapter Three
- S-Glutathionylation and Redox Protein Signaling in Drug Addiction ; Abstract; 1 Introduction ; 2 Oxidative Stress
- 3 S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress 4 S-Glutathionylation of Proteins is a Redox-Sensitive Signaling Mechanism in Cells ; 5 S-Glutathionylation in Addiction-Related Protein Signaling ; 5.1 Drug Addiction, Dopamine, and Oxidative Stress ; 5.2 Altered Neurotransmission in Response to Ethanol, Cocaine, and Opioids Share Common Signaling Mechanisms ; 6 S-Glutathionylation of PKA, PKC, Cdk5, and Actin May Influence Drug Behavior ; 7 S-Glutathionylation in Alcohol Addiction ; 7.1 Ethanol Metabolism Increases ROS Production
- 7.2 Increased ROS Production May Contribute to the Behavioral Effects of Ethanol 7.3 Protein S-Glutathionylation in Response to Ethanol ; 8 S-Glutathionylation in Cocaine Addiction ; 8.1 Cocaine Metabolism Increases ROS Production ; 8.2 Increased ROS Production May Contribute to the Behavioral Effects of Cocaine ; 8.3 Protein S-Glutathionylation in Response to Cocaine ; 9 S-Glutathionylation in Heroin Addiction ; 9.1 Heroin Metabolism Increases ROS Production ; 9.2 Increased ROS Production May Contribute to the Behavioral Effects of Heroin