Molecular nutrition and diabetes : a volume in the molecular nutrition series /

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mauricio, Didac (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press is an imprint of Elsevier, 2015.
Temas:
Nutrient interactions.
Diabetes > Nutritional aspects.
Molecular biology.
Nutriments > Interaction.
Diab�ete > Aspect nutritionnel.
Biologie mol�eculaire.
molecular biology.
SCIENCE > Life Sciences > Anatomy & Physiology.
Diabetes > Nutritional aspects
Molecular biology
Nutrient interactions
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Series Preface
  • MOLECULAR NUTRITION AND DIABETES
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Preface
  • Acknowledgments
  • 1
  • GENERAL AND INTRODUCTORY ASPECTS
  • 1
  • Nutrition and Diabetes: General Aspects
  • 1. INTRODUCTION
  • 2. HISTORICAL PERSPECTIVE
  • 3. GUIDELINES
  • 3.1 Caloric Intake
  • 3.2 Carbohydrate
  • 3.3 Fat
  • 3.4 Protein
  • 3.5 Sweeteners
  • 3.6 Supplements
  • 3.7 Sodium Intake
  • 3.8 Translation into Food Intake
  • 4. EVIDENCE FROM CLINICAL TRIALS
  • 4.1 Macronutrient Composition
  • 4.1.1 Protein Content.
  • 4.1.1.1 Protein Intake in Diabetic Kidney Disease
  • 4.1.2 Carbohydrate Content and Quality
  • 4.1.2.1 Low GI
  • 4.1.3 Fat Content
  • 4.1.4 Summary
  • 4.2 Supplements
  • 4.2.1 Herbal Products
  • 4.2.2 Whole Grains
  • 4.2.3 Omega-3 Fatty Acids
  • 4.2.4 Nuts
  • 4.3 Micronutrients
  • 4.4 Eating Patterns
  • 4.4.1 Mediterranean (MED) Style
  • 4.4.2 Vegetarian and Vegan
  • 4.4.3 Dietary Approaches to Stop Hypertension (DASH)
  • 4.5 Carbohydrate Counting in T1D
  • 5. FURTHER RESEARCH
  • 6. CONCLUSIONS
  • References
  • 2
  • Dietary Patterns and Insulin Resistance
  • 1. INTRODUCTION
  • 2. CARBOHYDRATES.
  • 3. LIPIDS
  • 4. PROTEINS
  • 5. CONCLUDING REMARKS
  • References
  • 3
  • (Sb (B-Cell Metabolism, Insulin Production and Secretion: Metabolic Failure Resulting in Diabetes
  • 1. INTRODUCTION TO PANCREATIC (Sb (B-CELL METABOLISM AND METABOLIC LINKS TO INSULIN SECRETION
  • 2. THE ROLE OF GLUCOSE METABOLISM, FATTY ACID METABOLISM, AND AMINO ACID METABOLISM IN THE GENERATION OF METABOLIC STIMULUS-SECRETION COUPLING FACTORS
  • 2.1 Glucose Metabolism and Insulin Secretion
  • 2.1.1 Glucose Transporters and Glucokinase
  • 2.1.2 The First Phase of Insulin Secretion Is KATP+ Channel-Dependent.
  • 2.1.3 The Second Phase of Chronic Insulin Secretion Is KATP+ Independent
  • 2.2 Fatty Acid Metabolism and Insulin Secretion
  • 2.2.1 Free Fatty Acids and (Sb (B Cells
  • 2.2.2 (Sb (B oxidation of FFAs in (Sb (B-Cell Mitochondria
  • 2.2.3 A Critical Shift in FFA Metabolism Occurs after Glucose Influx: The "Trident Model" Hypothesis
  • 2.2.3.1 TCA/Malonyl-CoA Metabolic Signaling
  • 2.2.3.2 Glycerolipid/Fatty Acid Cycling
  • 2.2.3.3 G Protein-Coupled Receptor
  • 2.3 Amino Acid Metabolism and Insulin Secretion
  • 3. NUTRIENT REGULATION OF (Sb (B-CELL GENE EXPRESSION.
  • 4. METABOLIC FAILURE IN (Sb (B-CELL DYSFUNCTION AND ONSET OF DIABETES
  • 4.1 A Brief Introduction to Type 1 and Type 2 Diabetes
  • 4.2 Glucotoxicity
  • 4.3 (Sb (B-Cell Exhaustion
  • 4.4 Reactive Oxygen Species
  • 4.5 Maturity Onset Diabetes of the Young
  • 4.6 Lipotoxicity
  • 4.6.1 Lipotoxicity is Dependent on Lipid Structure and Exposure Time
  • 4.6.2 Reactive Oxygen Species
  • 4.7 ER Stress
  • 5. THE CROSS-TALK OF APOPTOSIS WITH ROS AND ER STRESS IN (Sb (B-CELL DYSFUNCTION
  • 6. CONCLUDING REMARKS
  • References
  • 4
  • Diet-Gene Interactions in the Development of Diabetes.

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