Anaerobiosis and stemness : an evolutionary paradigm /

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"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad underst...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Ivanovic, Zoran, 1963- (Autor), Vlaski-Lafarge, Marija (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, [2016]
Temas:
Anaerobiosis > Therapeutic use.
Stem cells > Therapeutic use.
Stem cells.
Anaerobiosis.
Cell differentiation.
Evolution (Biology)
Stem Cells
Anaerobiosis
Cell Hypoxia
Cell Lineage
Cell Differentiation
Biological Evolution
Ana�erobiose > Emploi en th�erapeutique.
Cellules souches > Emploi en th�erapeutique.
Cellules souches.
Ana�erobiose.
Cellules > Diff�erenciation.
�Evolution (Biologie)
evolution.
SCIENCE > Life Sciences > Zoology > General.
Anaerobic bacteria
Biotechnology > Materials
Stem cells > Research
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction : special remarks
  • What entity could be called a stem cell?
  • In situ Normoxia versus "hypoxia"
  • Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche
  • Low O2 concentrations and the maintenance of stem cells ex vivo
  • Quiescence/proliferation issue and stem cell niche
  • Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status
  • Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells
  • Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis
  • Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells
  • Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2
  • Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells
  • Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link
  • Harnessing anaerobic nature of stem cells for use in regenerative medicine
  • Cancer stem cell case and evolutionary paradigm.

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