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Multiple sclerosis : a mechanistic view /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press, an imprint of Elsevier,
[2016]
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; MULTIPLE SCLEROSIS: A MECHANISTIC VIEW; Copyright; Contents; Contributors; Preface; 1
- Clinical Manifestations of Multiple Sclerosis: An Overview; INTRODUCTION; MOTOR AND SENSORY MANIFESTATIONS; FATIGUE; COGNITIVE DECLINE; PSYCHIATRIC MANIFESTATIONS; OPTIC NEURITIS AND OTHER NEUROOPHTHALMOLOGIC MANIFESTATIONS; UVEITIS; UHTHOFF PHENOMENON; PULFRICH PHENOMENON; BRAIN STEM INVOLVEMENT IN MS; TRANSVERSE MYELITIS; CEREBELLAR INVOLVEMENT AND TREMOR IN MS; SEIZURES AND OTHER PAROXYSMAL FEATURES OF MS; PAINFUL SYNDROMES; BOWEL AND BLADDER DYSFUNCTION; MOVEMENT DISORDERS; References.
- 2
- Novel Therapies for Multiple Sclerosis: A Mechanistic ViewINTRODUCTION; LAQUINIMOD; MONOCLONAL ANTIBODIES AS NOVEL THERAPIES FOR MS; ALEMTUZUMAB; DACLIZUMAB; OCRELIZUMAB; OFATUMUMAB; RITUXIMAB; THE CONCEPT OF REMYELINATION AS THERAPY FOR MS; AntiLINGO-1; rHIgM22; References; 3
- Role of B Cells in the Pathogenesis of Multiple Sclerosis: Mechanisms of Action; Introduction; EVIDENCE OF B CELL INVOLVEMENT IN THE PATHOGENESIS OF MS AND FACTORS POINTING TO THE LIMITS OF T CELL ACTION; THE MECHANISM OF B CELL ACTION IN THE DEVELOPMENT AND PROGRESS OF MS; THE ROLE OF CLONALLY EXPANDED B CELLS.
- ROLE OF B CELLS IN PRIMING/ACTIVATING T CELLSREGULATORY B CELLS (BREGS); MEMORY B CELLS; THE ROLE OF MHC IN TRIGGERING MS; CONCLUSION; LIST OF ABBREVIATIONS; References; 4
- Role of CD4+ T Cells in the Pathophysiology of Multiple Sclerosis; SUMMARY; TRADITIONAL CNS INFLAMMATION VERSUS "NEUROINFLAMMATION"; ETIOLOGY OF MS; PHYSIOLOGICAL AND PATHOLOGICAL ROLES OF CD4+ T CELL SUBSETS; CLASSICAL TH1/TH2 IMMUNOREGULATORY AXIS IN MS AND ITS ANIMAL MODELS; Role of Th1 cells; Role of Th2 cells; Unconventional role of Th1 and Th2 cells; NOVEL TH17/TREG IMMUNOREGULATORY AXIS IN MS AND ITS ANIMAL MODELS.
- Role of Th17 cellsRole of Tregs; DO "GAIN-OF-FUNCTION" CHANGES AFFECT SUSCEPTIBILITY TO MS?; "T CELL EXHAUSTION" AS A PROTECTIVE MECHANISM AGAINST IMMUNOPATHOLOGY; PROTECTIVE ROLES OF PD-1 AND TIM-3 IN MS AND ITS ANIMAL MODELS; CONCLUSIONS; Acknowledgments; References; 5
- Granulocyte-Macrophage Colony-Stimulating Factor in Central Nervous System Autoimmunity; INTRODUCTION; THE ROLE OF GM-CSF IN EAE; GM-CSF PRODUCTION BY T CELLS IN MS; CONCLUSION; References; 6
- Role of Cytokine-Mediated Crosstalk between T Cells and Nonimmune Cells in the Pathophysiology of Multiple Sclerosis; INTRODUCTION.
- PATHOGENIC ROLES OF CD4+ T CELLSPATHOGENIC ROLES OF CD8+ T CELLS; T CELL SUBSETS WITH SUPPRESSIVE FUNCTIONS; PATHOGENIC ROLE OF NONIMMUNE CELLS: THE INFLAMMATION AMPLIFIER; THE MECHANISM OF AUTOREACTIVE T CELL INVASION INTO THE CNS; CONCLUSION; References; 7
- Vitamin D: Role in Pathogenesis of Multiple Sclerosis; INTRODUCTION; Geoepidemiology; Migration studies; Vitamin D: sources; Vitamin D: synthesis and metabolism; Vitamin D: molecular mechanism and genetic modulation; VITAMIN D AND GENETIC SUSCEPTIBILITY TO MS; VITAMIN D DEFICIENCY AS A RISK FACTOR FOR MS.