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SCIDIR_ocn928992401 |
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OCoLC |
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20231120112034.0 |
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m o d |
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151113t20162016ne ob 001 0 eng d |
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|a IDEBK
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|c IDEBK
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|a 930760070
|a 932332151
|a 934625100
|a 1066608349
|a 1105181411
|a 1105564044
|a 1235826778
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|a 0128010053
|q (electronic bk.)
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|a 9780128010051
|q (electronic bk.)
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|z 012800763X
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| 020 |
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|z 9780128007631
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|
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|a (OCoLC)928992401
|z (OCoLC)930760070
|z (OCoLC)932332151
|z (OCoLC)934625100
|z (OCoLC)1066608349
|z (OCoLC)1105181411
|z (OCoLC)1105564044
|z (OCoLC)1235826778
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| 050 |
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4 |
|a RC377
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| 060 |
0 |
0 |
|a 2016 B-537
|
| 060 |
1 |
0 |
|a WL 360
|
| 072 |
|
7 |
|a HEA
|x 039000
|2 bisacsh
|
| 072 |
|
7 |
|a MED
|x 014000
|2 bisacsh
|
| 072 |
|
7 |
|a MED
|x 022000
|2 bisacsh
|
| 072 |
|
7 |
|a MED
|x 112000
|2 bisacsh
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|a MED
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|2 bisacsh
|
| 082 |
0 |
4 |
|a 616.834
|2 23
|
| 245 |
0 |
0 |
|a Multiple sclerosis :
|b a mechanistic view /
|c edited by Alireza Minagar.
|
| 264 |
|
1 |
|a Amsterdam :
|b Academic Press, an imprint of Elsevier,
|c [2016]
|
| 264 |
|
4 |
|c �2016
|
| 300 |
|
|
|a 1 online resource (xvi, 521 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 504 |
|
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|a Includes bibliographical references and index.
|
| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed December 1, 2015).
|
| 505 |
0 |
|
|a Front Cover; MULTIPLE SCLEROSIS: A MECHANISTIC VIEW; Copyright; Contents; Contributors; Preface; 1 -- Clinical Manifestations of Multiple Sclerosis: An Overview; INTRODUCTION; MOTOR AND SENSORY MANIFESTATIONS; FATIGUE; COGNITIVE DECLINE; PSYCHIATRIC MANIFESTATIONS; OPTIC NEURITIS AND OTHER NEUROOPHTHALMOLOGIC MANIFESTATIONS; UVEITIS; UHTHOFF PHENOMENON; PULFRICH PHENOMENON; BRAIN STEM INVOLVEMENT IN MS; TRANSVERSE MYELITIS; CEREBELLAR INVOLVEMENT AND TREMOR IN MS; SEIZURES AND OTHER PAROXYSMAL FEATURES OF MS; PAINFUL SYNDROMES; BOWEL AND BLADDER DYSFUNCTION; MOVEMENT DISORDERS; References.
|
| 505 |
8 |
|
|a 2 -- Novel Therapies for Multiple Sclerosis: A Mechanistic ViewINTRODUCTION; LAQUINIMOD; MONOCLONAL ANTIBODIES AS NOVEL THERAPIES FOR MS; ALEMTUZUMAB; DACLIZUMAB; OCRELIZUMAB; OFATUMUMAB; RITUXIMAB; THE CONCEPT OF REMYELINATION AS THERAPY FOR MS; AntiLINGO-1; rHIgM22; References; 3 -- Role of B Cells in the Pathogenesis of Multiple Sclerosis: Mechanisms of Action; Introduction; EVIDENCE OF B CELL INVOLVEMENT IN THE PATHOGENESIS OF MS AND FACTORS POINTING TO THE LIMITS OF T CELL ACTION; THE MECHANISM OF B CELL ACTION IN THE DEVELOPMENT AND PROGRESS OF MS; THE ROLE OF CLONALLY EXPANDED B CELLS.
|
| 505 |
8 |
|
|a ROLE OF B CELLS IN PRIMING/ACTIVATING T CELLSREGULATORY B CELLS (BREGS); MEMORY B CELLS; THE ROLE OF MHC IN TRIGGERING MS; CONCLUSION; LIST OF ABBREVIATIONS; References; 4 -- Role of CD4+ T Cells in the Pathophysiology of Multiple Sclerosis; SUMMARY; TRADITIONAL CNS INFLAMMATION VERSUS "NEUROINFLAMMATION"; ETIOLOGY OF MS; PHYSIOLOGICAL AND PATHOLOGICAL ROLES OF CD4+ T CELL SUBSETS; CLASSICAL TH1/TH2 IMMUNOREGULATORY AXIS IN MS AND ITS ANIMAL MODELS; Role of Th1 cells; Role of Th2 cells; Unconventional role of Th1 and Th2 cells; NOVEL TH17/TREG IMMUNOREGULATORY AXIS IN MS AND ITS ANIMAL MODELS.
|
| 505 |
8 |
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|a Role of Th17 cellsRole of Tregs; DO "GAIN-OF-FUNCTION" CHANGES AFFECT SUSCEPTIBILITY TO MS?; "T CELL EXHAUSTION" AS A PROTECTIVE MECHANISM AGAINST IMMUNOPATHOLOGY; PROTECTIVE ROLES OF PD-1 AND TIM-3 IN MS AND ITS ANIMAL MODELS; CONCLUSIONS; Acknowledgments; References; 5 -- Granulocyte-Macrophage Colony-Stimulating Factor in Central Nervous System Autoimmunity; INTRODUCTION; THE ROLE OF GM-CSF IN EAE; GM-CSF PRODUCTION BY T CELLS IN MS; CONCLUSION; References; 6 -- Role of Cytokine-Mediated Crosstalk between T Cells and Nonimmune Cells in the Pathophysiology of Multiple Sclerosis; INTRODUCTION.
|
| 505 |
8 |
|
|a PATHOGENIC ROLES OF CD4+ T CELLSPATHOGENIC ROLES OF CD8+ T CELLS; T CELL SUBSETS WITH SUPPRESSIVE FUNCTIONS; PATHOGENIC ROLE OF NONIMMUNE CELLS: THE INFLAMMATION AMPLIFIER; THE MECHANISM OF AUTOREACTIVE T CELL INVASION INTO THE CNS; CONCLUSION; References; 7 -- Vitamin D: Role in Pathogenesis of Multiple Sclerosis; INTRODUCTION; Geoepidemiology; Migration studies; Vitamin D: sources; Vitamin D: synthesis and metabolism; Vitamin D: molecular mechanism and genetic modulation; VITAMIN D AND GENETIC SUSCEPTIBILITY TO MS; VITAMIN D DEFICIENCY AS A RISK FACTOR FOR MS.
|
| 650 |
|
0 |
|a Multiple sclerosis.
|
| 650 |
1 |
2 |
|a Multiple Sclerosis
|x physiopathology
|0 (DNLM)D009103Q000503
|
| 650 |
2 |
2 |
|a Multiple Sclerosis
|x diagnosis
|0 (DNLM)D009103Q000175
|
| 650 |
2 |
2 |
|a Multiple Sclerosis
|x therapy
|0 (DNLM)D009103Q000628
|
| 650 |
|
2 |
|a Multiple Sclerosis
|0 (DNLM)D009103
|
| 650 |
|
6 |
|a Scl�erose en plaques.
|0 (CaQQLa)201-0052729
|
| 650 |
|
7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Internal Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a Multiple sclerosis
|2 fast
|0 (OCoLC)fst01029018
|
| 700 |
1 |
|
|a Minagar, Alireza,
|e editor.
|
| 776 |
0 |
8 |
|i Printed edition:
|z 9780128007631
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128007631
|z Texto completo
|
