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Genetic control of malaria and dengue /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press is an imprint of Elsevier,
[2015]
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Genetic Control of Malaria and Dengue
- Copyright Page
- Contents
- List of Contributors
- Biography
- Chapter 1
- Chapter 2
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapters 8, 13
- Chapter 9
- Chapter 10
- Chapter 11
- Chapter 12
- Chapter 14
- Chapter 15
- Chapter 16
- Chapter 17
- Chapter 18
- Chapter 19
- 1 Transgenic Pests and Human Health: A Short Overview of Social, Cultural, and Scientific Considerations
- Introduction
- Current State of GMOs
- Dengue Fever and Malaria
- Dengue Fever
- Malaria
- Dengue and Malaria Control
- Things to Consider Before Implementing GMO Control Methods
- Allocating Resources Between Treatment and Control
- Economic Development
- Community Engagement
- Values and Ethics of Control Measures
- Stewardship
- Animal Welfare
- Justice As Fairness
- Precaution
- An Ethical, Cultural, and Social Framework
- Regulation, Deliberation, and Public Communication of Biotechnology
- Current US Regulation of Biotechnology
- Biotechnology and the Public Sphere
- Models of Public Communication
- Public Opinion of Transgenics
- Conclusions
- Acknowledgments
- References
- 2 Concept and History of Genetic Control
- Introduction
- Agricultural Applications of Genetic Control Lead the Field
- Eradication of the New World Screwworm Fly Cochliomyia hominivorax Using the Sterile Insect Technique
- Use of Genetic Sexing Strains in Mediterranean Fruit Fly SIT Programs
- The Australian Sheep Blowfly (Lucilia cuprina) Field Female Killing Strains
- The Current State of Using SIT to Control Agricultural Pests
- Attempts to Extend Genetic Control to Mosquitoes
- Progress Without Modern Biotechnology
- Cytoplasmic Incompatibility and Wolbachia Population Replacement
- Classical SIT
- Chromosome Rearrangements.
- Population Replacement Without Transgenesis
- Modern Biotechnology Attempts to Cover the Achilles Heel of Mosquito SIT
- Increasing Suppression Leveraging Larval Competition
- Paratransgenesis Using Transgenic Symbionts
- Population Replacement with Factors Detrimental to Mosquitoes
- Population Replacement with Beneficial Factors
- Acknowledgments
- References
- 3 Considerations for Disrupting Malaria Transmission in Africa Using Genetically Modified Mosquitoes, Ecology of Anopheline...
- Malaria in Africa: Current Situation
- Malaria Vectors in the African Region
- Malaria Parasites and Their Public Health Significance
- Current Approaches for Malaria Vector Control
- Biological and Ecological Considerations for GM Release and Monitoring
- Operational Considerations and Capacity Building in Africa
- References
- 4 Ecology of Malaria Vectors and Current (Nongenetic) Methods of Control in the Asia Region
- Malaria Risk in the South East Asia Region
- Ecology of Common Malaria Vectors
- Anopheles culicifacies
- Anopheles fluviatilis
- Anopheles stephensi
- Anopheles dirus
- Anopheles minimus
- Current (Nongenetic) Methods of Vector Control
- Indoor Residual Spraying
- Long-Lasting Insecticide-Treated Nets
- Source Reduction
- Integrated Vector Management
- Progress of (Nongenetic) Vector Control in the Asia Region
- Evidence of Success
- Evidence of Resistance to Insecticides
- Key Challenges
- Insecticide Resistance Monitoring
- Outdoor Biting
- Behavioral Changes of Vectors
- Conclusions
- References
- 5 Ecology of Anopheles darlingi, the Primary Malaria Vector in the Americas and Current Nongenetic Methods of Vector Control
- Introduction
- Ecology of Anopheles darlingi
- Larvae
- Adult Behavior
- Anopheles albimanus and Anopheles aquasalis: Regionally Important Vectors
- Colonization.
- Coevolution of Anopheles and Plasmodium
- Current Control of Anopheles darlingi
- Adult Stage
- Larval Stage
- Scenarios Post Local Elimination of Anopheles darlingi
- Conclusions
- Acknowledgments
- References
- 6 Considerations for Disrupting Dengue Virus Transmission
- Ecology of Aedes aegypti and Current (Nongenetic) Methods of Control
- Current Burden of Dengue
- Causes of Widespread Dengue Transmission
- Major Dengue Vectors Worldwide
- How Does the Ecology of Aedes aegypti Complicate Control Efforts?
- Domestication
- Density-Dependent Population Regulation
- Spatial Heterogeneity and Super-Producer Aquatic Habitats of Aedes aegypti
- Cryptic Aquatic Habitats
- Egg Quiescence
- Population Dynamics of Aedes aegypti and Dengue
- Main Current Limitations to Control Dengue
- Current Interventions to Control Mosquito Vectors
- Improving Mosquito Control
- Local Aedes Populations Should be Managed in Space and Time Using an Area-Wide Approach
- Effective Control Agent
- Efficient Delivery System of the Control Agent
- Sufficient Coverage
- Evaluation of Impact
- Perspectives of Success Using Genetically Modified Mosquitoes to Control Dengue Vectors
- Self-Limiting Population Suppression
- Self-Sustaining Vector Population Replacement
- References
- 7 The Challenge of Disrupting Vectorial Capacity
- Purpose
- Strategy: How Do We Use the Vector to Achieve Reductions in Parasite Transmission?
- Lessons Learnt?
- Effective Delivery
- Maintenance of the Quality of the Intervention
- Sustaining Effective Delivery
- Polyvalent Intervention
- GM Interventions: How Do We Manage the Expectations and Measure Impact
- Managing Expectation
- Measuring Impact
- References
- 8 Gene Insertion and Deletion in Mosquitoes
- Random Insertion of Genetic Elements
- Transposons
- Docking-Site-Based Integration.
- Other Recombinases
- Site-Specific Nucleases
- Homing Endonucleases
- Chimeric Nucleases (ZFNs and TALENs)
- CRISPR/Cas9
- Targeted Insertion of Genetic Elements Through Homologous Recombination
- Controlling Transgene Expression
- the Current State of the Mosquito Toolbox
- Promoters
- Identifying New Promoters, a Cautionary Tale
- Bipartite Tet Systems
- Other Bipartite Expression Systems
- Considerations and Outlook
- References
- 9 Gene Drive Strategies for Population Replacement
- Introduction
- Early Inspiration
- Promising New Systems
- Design Criteria
- Gene Drive Systems That Spread Via Target Site Cleavage and Repair
- Transposable Elements
- Homing Endonuclease Genes
- TALENs and ZFNs
- Clustered, Regularly Interspaced, Short Palindromic Repeats
- Toxin-Antidote Gene Drive Systems
- Medea
- Toxin-Antidote-Based Underdominance
- Killer-Rescue
- Other Confineable Toxin-Antidote Systems
- Translocations
- Conclusion
- Gene Drive for Any Situation
- Outstanding Issues and Future Outlook
- Acknowledgments
- References
- 10 Exploring the Sex-Determination Pathway for Control of Mosquito-Borne Infectious Diseases
- Introduction
- Current Genetic Methods and Strategies
- Sterile Insect Technique
- Incompatible Insect Technique
- Release of Insects Carrying a Dominant Lethal Gene
- A Sex Ratio Distorter in Aedes aegypti and a Synthetic Sex Ratio Distorter in Anopheles gambiae
- Sex Separation
- Self-Sustaining Population Replacement Strategies
- Sex Determination in Mosquitoes
- M Locus and the Y Chromosome
- Doublesex (dsx), Fruitless (fru), and the Elusive Transformer (tra)
- Dosage Compensation and Sex Determination
- Toward the Discovery of the M Factor and Tra
- Ways and Considerations to Explore the Sex-Determination Pathway for Control
- Targets and Sex-Specific Reagents.
- Sex Conversion Versus Female Lethality
- Timing of the Transgene Effect
- Conditional Expression
- "Driving Maleness" to Control Mosquito-Borne Infectious Diseases
- Acknowledgments
- References
- 11 Disruption of Mosquito Olfaction
- Introduction
- Anatomy of the Mosquito Olfactory System
- Chemosensory Receptors Detecting Odorants and CO2 in Drosophila and Mosquitoes
- Odorant Receptors
- Ionotropic Receptors
- Gustatory Receptors
- Use of Genome-Editing Technology to Decode Mosquito Attraction to Humans
- Targeted Mutagenesis of OR-Mediated Odorant Reception
- Targeted Mutagenesis of CO2 Reception
- Proposed Genetic Strategies Targeting Mosquito Olfaction
- Next-Generation Chemical Strategies Targeting Mosquito Olfaction
- Conclusions
- Acknowledgments
- References
- 12 Disruption of Mosquito Blood Meal Protein Metabolism
- Introduction: An Overview of Blood Meal Protein Metabolism in Mosquitoes
- Exploring Blood Meal Protein Amino Acid Carbon Skeletons Using Radioactive Isotopes
- Dynamics of Blood Meal Protein Amino Acid Metabolism
- Fate of Blood Meal Amino Acids at the End of the Gonotrophic Cycle and Utilization of Maternal Energy Reserves During a Gon...
- Investigating Blood Meal Protein Amino Acid Nitrogen Using Traditional and Modern Approaches
- Fate of Nitrogen Derived from Deamination of Amino Acids Using Classical Biochemical and Molecular Techniques
- Fate of Nitrogen Derived from Deamination of Amino Acids Using Isotopically-Labeled 15N-Compounds, Mass Spectrometry, and R...
- Fixation and Assimilation of Ammonia
- Excretion of Nitrogen Waste Products
- Conclusions and Future Directions
- Acknowledgments
- References
- 13 Engineering Pathogen Resistance in Mosquitoes
- Malaria and Dengue
- Malaria
- Dengue
- Engineering Resistance to Pathogens
- Pathogen-Derived Resistance (RNAi).