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00000cam a2200000 i 4500 |
001 |
SCIDIR_ocn920551933 |
003 |
OCoLC |
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20231120112020.0 |
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m o d |
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cr cnu---unuuu |
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150909t20152016enk ob 001 0 eng d |
040 |
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|a OPELS
|b eng
|e rda
|e pn
|c OPELS
|d YDXCP
|d OCLCF
|d N$T
|d IDEBK
|d EBLCP
|d OCLCQ
|d ESU
|d DEBBG
|d B3G
|d BRA
|d MERUC
|d COS
|d COF
|d U3W
|d D6H
|d ESEHU
|d AU@
|d OCLCQ
|d WYU
|d OCLCA
|d MERER
|d OCLCO
|d OCLCA
|d OCLCQ
|d UKMGB
|d VT2
|d OCLCQ
|d OCLCO
|d OCL
|d OCLCQ
|d OCLCO
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066 |
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|c (S
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015 |
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|a GBB5A6313
|2 bnb
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016 |
7 |
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|a 017472715
|2 Uk
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019 |
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|a 1066447827
|a 1235842422
|
020 |
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|a 9780128011812
|q (electronic bk.)
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020 |
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|a 0128011815
|q (electronic bk.)
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020 |
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|z 9780128010099
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020 |
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|z 0128010096
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035 |
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|a (OCoLC)920551933
|z (OCoLC)1066447827
|z (OCoLC)1235842422
|
050 |
|
4 |
|a QP552.P4
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060 |
|
4 |
|a 2016 A-909
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060 |
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4 |
|a QU 68
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072 |
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7 |
|a SCI
|x 007000
|2 bisacsh
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082 |
0 |
4 |
|a 572/.65
|2 23
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100 |
1 |
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|a Yang, Yi,
|e author.
|
245 |
1 |
0 |
|a Side reactions in peptide synthesis /
|c Yi Yang.
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264 |
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1 |
|a London, UK :
|b Academic Press is an imprint of Elsevier,
|c [2015]
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264 |
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4 |
|c �2016
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300 |
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|a 1 online resource
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336 |
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|a text
|b txt
|2 rdacontent
|
337 |
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|a computer
|b c
|2 rdamedia
|
338 |
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|a online resource
|b cr
|2 rdacarrier
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520 |
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|a This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.
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500 |
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|a Includes index.
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588 |
0 |
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|a Title details screen (ScienceDirect, viewed September 9, 2015).
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505 |
0 |
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|6 880-01
|a Cover; Title Page; Copyright Page; Dedication; Contents; Preface; Chapter 1 -- Peptide Fragmentation/Deletion Side Reactions; 1.1 -- Acidolysis of peptides containing N-Ac-N-alkyl-Xaa motif; 1.2 -- des-Ser/Thr impurities induced by O-acyl isodipeptide Boc-Ser/Thr(Fmoc-Xaa)-OH as building block for peptide synthesis; 1.3 -- Acidolysis of -N-acyl-N-alkyl-Aib-Xaa- bond; 1.4 -- Acidolysis of -Asp-Pro- bond; 1.5 -- Autodegradation of peptide N-terminal H-His-Pro-Xaa- moiety; 1.6 -- Acidolysis of the peptide C-terminal N-Me-Xaa; 1.7 -- Acidolysis of peptides with N-terminal FITC modification.
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505 |
8 |
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|a 3.3 -- Formation of Trp-EDT and Trp-EDT-TFA adduct in peptide global deprotection3.4 -- Trp dimerization side reaction during peptide global deprotection; 3.5 -- Trp reduction during peptide global deprotection; 3.6 -- Cys alkylation during peptide global deprotection; 3.7 -- Formation of Cys-EDT adducts in peptide global deprotection reaction; 3.8 -- Peptide sulfonation in side chain global deprotection reaction; 3.9 -- Premature Acm cleavage off Cys(Acm) and Acm S₂!O migration during peptide global deprotection.
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505 |
8 |
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|a 3.10 -- Methionine alkylation during peptide side chain global deprotection with DODT as scavenger3.11 -- Thioanisole-induced side reactions in peptide side chain global deprotection; References; Chapter 4 -- Peptide Rearrangement Side Reactions; 4.1 -- Acid catalyzed acyl N₂! migration and the subsequent peptide acidolysis; 4.2 -- Base catalyzed acyl O₂! migration; 4.3 -- His-Nim- induced acyl migration; References; Chapter 5 -- Side Reactions Upon Amino Acid/Peptide Carboxyl Activation; 5.1 -- Formation of N-acylurea upon peptide/amino acid-carboxyl activation by DIC.
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505 |
8 |
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|a 5.8 -- Peptide chain termination through the formation of peptide N-terminal urea in CDI-mediated coupling reaction.
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504 |
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|a Includes bibliographical references and index.
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650 |
|
0 |
|a Peptides
|x Synthesis.
|
650 |
|
0 |
|a Drugs
|x Side effects.
|
650 |
1 |
2 |
|a Peptide Biosynthesis
|0 (DNLM)D010452
|
650 |
2 |
2 |
|a Peptides
|x chemistry
|0 (DNLM)D010455Q000737
|
650 |
2 |
2 |
|a Drug-Related Side Effects and Adverse Reactions
|0 (DNLM)D064420
|
650 |
|
6 |
|a Peptides
|x Synth�ese.
|0 (CaQQLa)201-0074773
|
650 |
|
6 |
|a M�edicaments
|x Effets secondaires.
|0 (CaQQLa)201-0002241
|
650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Biochemistry.
|2 bisacsh
|
650 |
|
7 |
|a Drugs
|x Side effects
|2 fast
|0 (OCoLC)fst00898912
|
650 |
|
7 |
|a Peptides
|x Synthesis
|2 fast
|0 (OCoLC)fst01057580
|
776 |
0 |
8 |
|i Print version:
|z 9780128010099
|
856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128010099
|z Texto completo
|
880 |
8 |
|
|6 505-00/(S
|a 1.8 -- Acidolysis of thioamide peptide1.9 -- Deguanidination side reaction on Arg; 1.10 -- DKP (2,5-diketopiperazine) formation; References; Chapter 2 -- β-Elimination Side Reactions; 2.1 -- β-Elimination of Cys sulfhydryl side chain; 2.2 -- β-Elimination of phosphorylated Ser/Thr; References; Chapter 3 -- Peptide Global Deprotection/Scavenger-Induced Side Reactions; 3.1 -- Tert-butylation side reaction on Trp during peptide global deprotection; 3.2 -- Trp alkylation by resin linker cations during peptide cleavage/global deprotection.
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880 |
8 |
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|6 505-01/(S
|a 5.2 -- Uronium/Guanidinium salt coupling reagents-induced amino group guanidination side reactions5.3 -- δ-lactam formation upon Arg activation reaction; 5.4 -- NCA formation upon Boc/Z-Amino acid activation; 5.5 -- Dehydration of side chain-unprotected Asn/Gln during carboxyl-activation; 5.6 -- Formation of H-β-Ala-OSu from HOSu-carbodiimide reaction during amino acid carboxyl-activation; 5.7 -- Benzotriazinone ring opening and peptide chain termination during carbodiimide/HOOBt mediated coupling reactions.
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