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DNA methylation and complex human disease /
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, i...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2016.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 020 | |z 9780124201941 | ||
| 020 | |z 0124201946 | ||
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| 100 | 1 | |a Neidhart, Michel, |e author. | |
| 245 | 1 | 0 | |a DNA methylation and complex human disease / |c Michel Neidhart. |
| 264 | 1 | |a Amsterdam : |b Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed August 20, 2015). | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a ""Front Cover""; ""DNA Methylation and Complex Human Disease""; ""Copyright Page""; ""Contents""; ""Preface""; ""About the Author""; ""1 DNA Methylation �a�? Introduction""; ""1.1 Epigenetics""; ""1.2 Histone Modifications""; ""1.2.1 Histone Acetylation and Deacetylation""; ""1.2.2 Histone Methylation""; ""1.3 DNA Methylation""; ""1.3.1 DNA Methyltransferases""; ""1.4 Methyl-Binding Domain Proteins""; ""1.5 DNA Demethylation""; ""1.6 DNA Hydroxymethylation""; ""1.7 Differentially Methylated Regions""; ""1.8 Nutriepigenomics""; ""References"" | |
| 505 | 8 | |a ""2 DNA Methylation and Epigenetic Biomarkers in Cancer""""2.1 Introduction""; ""2.1.1 Diagnosis Biomarkers""; ""2.1.2 Progression Biomarkers""; ""2.1.3 Predictive Biomarkers""; ""2.1.4 Discovery of Novel Biomarkers""; ""2.2 Cancerogenesis""; ""2.3 Epimutations in Cancer""; ""2.3.1 Esophageal Adenocarcinoma""; ""2.3.2 Gastric Cancer""; ""2.3.3 Colorectal Carcinoma""; ""2.3.4 Lynch Syndrome""; ""2.3.5 Endometrial and Ovarian Cancers""; ""2.3.6 Lung Cancer""; ""2.3.7 Glioblastoma""; ""2.3.8 Hematopoietic Cancers""; ""2.4 Conclusion""; ""References"" | |
| 505 | 8 | |a ""3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases""""3.1 Introduction""; ""3.2 Autoimmunity""; ""3.2.1 Type 1 Diabetes""; ""3.2.2 Rheumatoid Arthritis""; ""3.2.3 Systemic Lupus Erythematosis""; ""3.2.4 Inflammatory Bowel Disease, Crohn�a�?s Disease, and Ulcerative Colitis""; ""3.3 Metabolic Diseases""; ""3.3.1 Type 2 Diabetes""; ""3.3.2 Heart Failure""; ""3.4 Developmental Diseases""; ""3.4.1 Imprinting Disorders""; ""3.4.2 Arrhythmia""; ""3.5 Psychiatric Diseases""; ""3.5.1 Major Depressive Disorder""; ""3.5.2 Schizophrenia""; ""3.6 Conclusion""; ""References"" | |
| 505 | 8 | |a ""4 DNA Methylation and Environmental Factors""""4.1 Introduction""; ""4.2 Impact of the Environment in Early Life""; ""4.2.1 Genomic Imprinting""; ""4.2.2 Beckwith-Wiedemann Syndrome""; ""4.2.3 Assisted Reproductive Technologies""; ""4.2.4 Large Offspring Syndrome""; ""4.3 Nutritional Factors""; ""4.3.1 Gestational Maternal Nutritional Factors""; ""4.3.2 Nutritional Deficiencies""; ""4.4 Adverse Environmental Factors""; ""4.4.1 Environmental Toxicants""; ""4.4.2 Ethanol Consumption""; ""4.4.3 Smoking""; ""4.5 Immune Activation""; ""4.5.1 Asthma and Allergy""; ""4.5.2 Bacterial Infections"" | |
| 505 | 8 | |a ""4.5.3 Viral Infections""""4.6 Maternal Mood and Experience in Early Life""; ""4.7 Physical Exercise""; ""4.8 Conclusion""; ""References""; ""5 DNA Methylation and Epidemiology""; ""5.1 Introduction""; ""5.2 Endocrine Disrupting Chemicals""; ""5.2.1 Bisphenol-A""; ""5.2.2 Diethylstillbestrol""; ""5.2.3 Cadmium""; ""5.3 Epigenomics and Breast Cancer""; ""5.3.1 RASSF1A""; ""5.3.2 P16/CDKN2A""; ""5.4 Tobacco Smoking""; ""5.4.1 F2RL3, Smoking, and Cardiovascular Diseases""; ""5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas""; ""5.4.3 AHRR, Smoking, and Lung Metastasis"" | |
| 520 | |a DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati. | ||
| 650 | 0 | |a DNA |x Methylation. | |
| 650 | 0 | |a Medical genetics. | |
| 650 | 2 | |a DNA Methylation |0 (DNLM)D019175 | |
| 650 | 2 | |a Genetics, Medical |0 (DNLM)D005826 | |
| 650 | 6 | |a ADN |0 (CaQQLa)201-0008510 |x M�ethylation. |0 (CaQQLa)201-0379673 | |
| 650 | 6 | |a G�en�etique m�edicale. |0 (CaQQLa)201-0001432 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a DNA |x Methylation |2 fast |0 (OCoLC)fst00886570 | |
| 650 | 7 | |a Medical genetics |2 fast |0 (OCoLC)fst01014133 | |
| 776 | 0 | 8 | |i Print version: |a Neidhart, Michel. |t DNA methylation and complex human disease. |d Amsterdam : Elsevier, 2016 |z 9780124201941 |z 0124201946 |w (OCoLC)885228983 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780124201941 |z Texto completo |