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Biochemistry of lipids, lipoproteins and membranes /
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, off...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2016.
|
| Edición: | Sixth edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Biochemistry of lipids, lipoproteins and membranes / |c edited by Neale Ridgway and Roger McLeod. |
| 250 | |a Sixth edition. | ||
| 264 | 1 | |a Amsterdam : |b Elsevier, |c 2016. | |
| 264 | 4 | |c �2016 | |
| 300 | |a 1 online resource | ||
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| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed July 29, 2015). | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. | ||
| 505 | 0 | |6 880-01 |a Front Cover; Biochemistry of Lipids, Lipoproteins and Membranes; Copyright; Contents; Contributors; Preface; Chapter 1 -- Functional Roles of Lipids in Membranes; 1. INTRODUCTION AND OVERVIEW; 2. DIVERSITY IN LIPID STRUCTURE; 3. PROPERTIES OF LIPIDS IN SOLUTION; 4. ENGINEERING OF MEMBRANE LIPID COMPOSITION; 5. ROLE OF LIPIDS IN CELL FUNCTION; 6. SUMMARY AND FUTURE DIRECTIONS; REFERENCES; Chapter 2 -- Approaches to Lipid Analysis; 1. INTRODUCTION AND OVERVIEW; 2. LIPID DIVERSITY; 3. CHROMATOGRAPHIC-BASED ANALYSIS OF LIPIDS; 4. BASIC CONCEPTS OF ANALYTICAL BIOCHEMISTRY; 5. LIPID MASS SPECTROMETRY. | |
| 505 | 8 | |a 6. FUTURE DIRECTIONSREFERENCES; Chapter 3 -- Fatty Acid and Phospholipid Biosynthesis in Prokaryotes; 1. OVERVIEW OF BACTERIAL LIPID METABOLISM; 2. MEMBRANE SYSTEMS OF BACTERIA; 3. THE INITIATION MODULE; 4. THE ELONGATION MODULE; 5. THE ACYLTRANSFER MODULE; 6. THE PHOSPHOLIPID MODULE; 7. GENETIC REGULATION OF LIPID METABOLISM; 8. FUTURE DIRECTIONS; REFERENCES; Chapter 4 -- Lipid Metabolism in Plants; 1. INTRODUCTION; 2. PLANT LIPID GEOGRAPHY; 3. ACYL-ACYL CARRIER PROTEIN SYNTHESIS IN PLANTS; 4. ACETYL-COENZYME A CARBOXYLASE AND CONTROL OF FATTY ACID SYNTHESIS. | |
| 505 | 8 | |a 5. PHOSPHATIDIC ACID SYNTHESIS OCCURS VIA PROKARYOTIC AND EUKARYOTIC ACYLTRANSFERASES6. MEMBRANE GLYCEROLIPID SYNTHESIS; 7. LIPID STORAGE IN PLANTS; 8. PROTECTIVE LIPIDS: CUTIN, WAXES, SUBERIN AND SPOROPOLLENIN; 9. SPHINGOLIPID BIOSYNTHESIS; 10. OXYLIPINS AS PLANT HORMONES; 11. STEROL AND ISOPRENOID BIOSYNTHESIS; 12. FUTURE PROSPECTS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 5 -- Fatty Acid Handling in Mammalian Cells; 1. INTRODUCTION; 2. FATTY ACID BIOSYNTHESIS; 3. FATTY ACID UPTAKE, ACTIVATION AND TRAFFICKING; 4. FATTY ACID STORAGE AS TRIACYLGLYCEROL IN LIPID DROPLETS. | |
| 505 | 8 | |a 5. FATTY ACID USE FOR ENERGY6. FATTY ACIDS AND SIGNALLING; 7. FATTY ACIDS AND DISEASE PATHOGENESIS; 8. FUTURE DIRECTIONS; REFERENCES; Chapter 6 -- Fatty Acid Desaturation and Elongation in Mammals; 1. INTRODUCTION; 2. ELONGATION REACTIONS OF LONG-CHAIN FATTY ACIDS; 3. DESATURATION OF LONG-CHAIN FATTY ACID IN MAMMALS; 4. TRANSCRIPTIONAL REGULATION OF DESATURASES AND ELONGASES; 5. SUMMARY AND FUTURE DIRECTIONS; REFERENCES; Chapter 7 -- Phospholipid Synthesis in Mammalian Cells; 1. INTRODUCTION; 2. BIOSYNTHESIS OF PHOSPHATIDIC ACID AND DIACYLGLYCEROL. | |
| 505 | 8 | |a 3. PHOSPHATIDYLCHOLINE BIOSYNTHESIS AND REGULATION4. PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS AND REGULATION; 5. PHOSPHATIDYLSERINE BIOSYNTHESIS AND REGULATION; 6. PHOSPHATIDYLINOSITOL AND POLYPHOSPHORYLATED PHOSPHATIDYLINOSITOL; 7. BIOSYNTHESIS OF PHOSPHATIDYLGLYCEROL AND CARDIOLIPIN; 8. FATTY ACID REMODELLING OF PHOSPHOLIPIDS; 9. FUTURE DIRECTIONS; REFERENCES; Chapter 8 -- Phospholipid Catabolism; 1. INTRODUCTION; 2. THE PHOSPHOLIPASE A FAMILY; 3. PHOSPHOLIPASE C; 4. PHOSPHOLIPASE D; 5. FUTURE DIRECTIONS; REFERENCES. | |
| 505 | 8 | |a Chapter 9 -- The Eicosanoids: Cyclooxygenase, Lipoxygenase and Epoxygenase Pathways. | |
| 650 | 0 | |a Lipids |x Metabolism. | |
| 650 | 0 | |a Lipoproteins |x Metabolism. | |
| 650 | 0 | |a Membrane lipids |x Metabolism. | |
| 650 | 0 | |a Cellular signal transduction. | |
| 650 | 1 | 2 | |a Lipid Metabolism |0 (DNLM)D050356 |
| 650 | 2 | 2 | |a Cell Membrane |x physiology |0 (DNLM)D002462Q000502 |
| 650 | 2 | 2 | |a Lipoproteins |x metabolism |0 (DNLM)D008074Q000378 |
| 650 | 2 | 2 | |a Signal Transduction |0 (DNLM)D015398 |
| 650 | 6 | |a Lipides |x M�etabolisme. |0 (CaQQLa)201-0025368 | |
| 650 | 6 | |a Lipoprot�eines |x M�etabolisme. |0 (CaQQLa)201-0423854 | |
| 650 | 6 | |a Lipides membranaires |0 (CaQQLa)201-0220895 |x M�etabolisme. |0 (CaQQLa)201-0379985 | |
| 650 | 6 | |a Transduction du signal cellulaire. |0 (CaQQLa)201-0206812 | |
| 650 | 7 | |a MEDICAL |x Physiology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Human Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Cellular signal transduction. |2 fast |0 (OCoLC)fst00850288 | |
| 650 | 7 | |a Lipids |x Metabolism. |2 fast |0 (OCoLC)fst00999374 | |
| 650 | 7 | |a Lipoproteins |x Metabolism. |2 fast |0 (OCoLC)fst00999405 | |
| 650 | 7 | |a Membrane lipids |x Metabolism. |2 fast |0 (OCoLC)fst01015846 | |
| 653 | 0 | 0 | |a lipiden |
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| 653 | 0 | 0 | |a biochemie |
| 653 | 0 | 0 | |a biochemistry |
| 653 | 1 | 0 | |a Biochemistry |
| 653 | 1 | 0 | |a Biochemie |
| 700 | 1 | |a Ridgway, Neale, |e editor. | |
| 700 | 1 | |a McLeod, Roger, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Biochemistry of lipids, lipoproteins and membranes. |b Sixth edition. |d Amsterdam, Netherlands : Elsevier, �2016 |h xxiii, 599 pages |z 9780444634382 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444634382 |z Texto completo |
| 880 | 0 | 0 | |6 505-01/(S |g Contents note continued: |g 4.1. |t Catabolism of Chylomicrons by Low Desity Lipoprotein Receptor-Related Protein 1 -- |g 4.2. |t The So-Called Very Low-Density Lipoprotein Receptor: A Role in Catabolism of Very Low Density Lipoprotein-- |g 4.3. |t A Multifunctional Very Low Density Lipoprotein Receptor in the Chicken -- |g 5. |t Other Relatives of the Low-Density Lipoprotein Receptor Family -- |g 5.1. |t ApoER2---A Close Relative of the Very Low Density Lipoprotein Receptor -- |g 5.2. |t Small and Midsize Low-Density Lipoprotein Receptor Relatives: LRP 3, 4, 5 and 6 -- |g 5.3. |t The Unusual One: LR11 -- |g 5.4. |t Large Low-Density Lipoprotein Receptor Relatives: LRP2 and LRP1B -- |g 6. |t Roles of Lipoprotein Receptors in Signal Transduction -- |g 6.1. |t Genetic Models Reveal New Roles for apoER2 and Very Low Density Lipoprotein Receptor in Signal Transduction -- |g 6.2. |t Signalling through LRP1 -- |g 7. |t Scavenger Receptors: Lipid Uptake and Beyond -- |g 7.1. |t Class A Scavenger Receptors -- |g 7.2. |t Lectin-Like Oxidised Low-Density Lipoprotein Receptor -- |g 7.3. |t Class B Scavenger Receptors -- |g 8. |t Outlook -- |t References -- |g 18. |t Atherosclerosis / |r Hong Lu -- |g 1. |t Atherosclerosis -- |g 2. |t Lipoprotein Transport in Atherosclerosis -- |g 2.1. |t Low-Density Lipoprotein -- |g 2.2. |t Very-Low-Density Lipoprotein -- |g 2.3. |t Remnants of VLDL and Chylomicrons -- |g 2.4. |t Lipoprotein(a) -- |g 2.5. |t High-Density Lipoprotein -- |g 3. |t Lipoprotein Receptors and Lipid Transporters -- |g 3.1. |t LDL Receptors -- |g 3.2. |t Scavenger Receptors -- |g 3.3. |t Low-Density Lipoprotein Receptor-Related Protein -- |g 3.4. |t ATP-Binding Cassette Subfamily (ABCs) -- |g 4. |t Contributions of Lipoprotein-Mediated Inflammation to Atherosclerosis -- |g 4.1. |t Cell Types Involved in Atherosclerotic Lesions -- |g 4.2. |t Foam Cells -- |g 4.3. |t Macrophage Polarisation -- |g 4.4. |t Inflammatory Responses -- |g 4.5. |t Atherosclerotic Lesion Macrophage Retention and Emigration -- |g 4.6. |t Atherosclerotic Lesion Regression -- |g 5. |t New Emerging Mechanisms of Lipid Metabolism Influencing Atherosclerosis -- |g 5.1. |t MicroRNAs -- |g 5.2. |t Inflammasomes -- |g 5.3. |t Trimethylamine and Trimethylamine-N-oxide -- |g 6. |t Traditional and Evolving Lipid-Lowering Therapies for the Treatment of Atherosclerosis -- |g 6.1. |t Statins -- |g 6.2. |t Fibrates -- |g 6.3. |t Niacin -- |g 6.4. |t Cholesterol Absorption Inhibitors -- |g 6.5. |t ω-3 Polyunsaturated Fatty Acids -- |g 6.6. |t Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors -- |g 6.7. |t ASO Therapies -- |g 6.8. |t Microsomal Triacylglyceride Transfer Protein Inhibitors -- |g 6.9. |t ACAT and DGAT Inhibitors -- |g 6.1. |t 0 High-Density Lipoprotein Modulating Drugs -- |g 7. |t Future Directions -- |t References -- |g 19. |t Diabetic Dyslipidaemia / |r Gary F. Lewis -- |g 1. |t Introduction to the Typical Dyslipidaemia of Insulin-Resistant States -- |g 1.1. |t Major Dyslipidaemia of Insulin-Resistant States: Hypertriglyceridaemia, Low HDL and Qualitative Changes in Low-Density Lipoprotein (Small, Dense Low-Density Lipoprotein) -- |g 1.2. |t Lipid Profile of Individuals with T1D -- |g 1.3. |t Role of Diabetic Dyslipidaemia in Atherosclerosis and CVD -- |g 1.4. |t Aetiology of the Dyslipidaemia: Genetic and Environmental Factors -- |g 2. |t Dyslipidaemia of Insulin-Resistant States: Key Factors and Mechanisms, with a Focus on Hepatic Lipoprotein Overproduction -- |g 2.1. |t Apolipoprotein B-Containing Lipoproteins: Alterations in Insulin Resistance and T2D -- |g 2.2. |t Molecular Mechanisms Underlying Hepatic Insulin Resistance and Increased VLDL Secretion -- |g 2.3. |t Mechanisms of Hepatic VLDL Overproduction in Insulin Resistance: Multiorgan Cross Talk, Hormones and Dietary Factors -- |g 2.4. |t Association of Fatty Liver/Inflammation and Diabetic Dyslipidaemia -- |g 3. |t Postprandial Dyslipidaemia and Intestinal Chylomicrons Hypersecretion in Insulin-Resistant States -- |g 3.1. |t Mechanisms of Intestinal Lipoprotein Overproduction in Insulin-Resistant States -- |g 3.2. |t Lipid and Carbohydrate Regulation of Intestinal Lipoprotein Secretion -- |g 3.3. |t Alterations in Other Pathways Involved in Lipoprotein Assembly and Secretion -- |g 3.4. |t Gut Peptides and Inflammatory Factors Affect Intestinal Lipoprotein Secretion -- |g 4. |t Low High-Density Lipoprotein in Insulin Resistance and Type 2 Diabetes -- |g 4.1. |t HDL Lowering Due to Increased Catabolism in Hypertriglyceridaemia and Insulin Resistance -- |g 4.2. |t Increased Apolipoprotein A-l Catabolism Due to TG Enrichment, Combined with Increased HL Activity -- |g 4.3. |t Role of Inflammation and Endothelial Lipase in HDL Metabolism -- |g 5. |t Treatment of the Dyslipidaemia of Insulin-Resistant States -- |g 5.1. |t Lifestyle Modification -- |g 5.2. |t Pharmacotherapies -- |g 6. |t Conclusions -- |t References. |