Cargando…
Advances in immunology Volume 127 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam [Netherlands] :
Academic Press,
2015.
|
| Edición: | First edition. |
| Colección: | Advances in immunology ;
Volume 127. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Cross-Presentation in Mouse and Human Dendritic Cells; 1. Introduction; 2. Molecular Mechanisms of Cross-Presentation; 2.1. Cytosolic Versus Vacuolar Pathway; 2.2. Regulation of Antigen Degradation in the Endocytic Pathway; 2.3. Antigen Export to the Cytosol; 2.4. Loading of MHC Class I Molecules: ER Versus Phagosomes; 2.5. DC Activation and Regulation of the Cross-Presentation Pathway; 3. DC Subsets and Cross-Presentation; 3.1. Overview of Mouse and Human DC Subsets
- 3.2. Mouse DC Subsets and Cross-Presentation3.3. Human DC Subsets and Cross-Presentation; 4. Cross-Presentation in Pathological Situations; 4.1. Cross-Presentation During Viral Infections; 4.2. Cross-Presentation in Autoimmunity; 4.3. Cross-Presentation in Cancer; 5. Conclusion and Perspectives; Acknowledgments; References; Chapter Two: HLA-G: An Immune Checkpoint Molecule; 1. Introduction; 2. Fundamental Aspects of HLA-G Biology; 2.1. The HLA-G Gene; 2.2. HLA-G Expression; 2.2.1. Sites of Expression; 2.2.2. Regulation of HLA-G Expression; 2.2.2.1. Transcriptional Regulation
- 2.2.2.2. Microenvironment and Therapeutic Modulators2.2.2.3. DNA Methylation and Histone Modifications; 2.2.2.4. Posttranscriptional Regulation: The Role of MicroRNAs; 2.2.2.4.1. miRNAs That Target HLA-G; 2.2.2.4.2. Molecular Modifications Following HLA-G Administration; 2.3. HLA-G Gene Polymorphism; 2.3.1. Genetic Variations at the HLA-G Locus; 2.3.1.1. Variability of the 5'-Regulatory Region; 2.3.1.2. Variability of the Coding Region; 2.3.1.3. Variability of the 3-UTR; 2.3.1.4. Variability of the Complete Alleles: Extended Haplotypes; 2.3.2. Evolution of the HLA-G Gene
- 2.3.3. Impact of Polymorphism on HLA-G Expression2.4. The HLA-G Proteins; 2.4.1. HLA-G Isoforms; 2.4.2. Assembly and Recycling; 2.4.3. Posttranslational Modifications of HLA-G; 2.4.4. Monomers/Dimers; 2.4.4.1. The HLA-G Monomers; 2.4.4.2. The HLA-G Dimers; 2.4.5. Extracellular Vesicles; 2.5. The HLA-G Receptors; 2.5.1. LILRB1/ILT2 and LILRB2/ILT4; 2.5.2. KIR2DL4 and Other Receptors; 2.5.2.1. KIR2DL4; 2.5.2.2. CD8; 2.5.2.3. CD160/BY55; 2.5.3. Molecular Events Triggered by HLA-G Binding to Its Receptors; 2.5.3.1. HLA-G Localization and Recruitment to Lipid Rafts