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The origin of chronic inflammatory systemic diseases and their sequelae /
Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on....
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Academic Press,
2015.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae; Copyright; Dedication ; Contents; Preface; Acknowledgments; Chapter I: History of Immunology Research; Before 1945: The Early Days; 1945-1960: Immunology Reawakens; 1960-Today: Pure Immunology; Summary; Pathogenic Effector Mechanisms of Chronic Inflammatory Systemic Diseases; Autoantibody, Immune Complex, and Complement; B Cells and Plasma Cells; T Cells; MHC and Immunogenetics; Monocytes and Macrophages; Dendritic Cells; NK Cells; Neutrophils; Apoptosis.
- Adhesion and Costimulatory Molecules, Vascular Transmigration, and ChemokinesPattern Recognition Receptors; The Local Cellular Support System of Inflammation; Fibroblasts and Astrocytes; Stromal Cells of the Bone Marrow; Endothelial Cells, Mesangial Cells, and Neovascularization; Epithelial Cells; Keratinocytes; Oligodendrocytes; Adipocytes; Myocytes; Eosinophils, Basophils, and Mast Cells; Signaling Pathways: Genome-Wide Association Studies; The Trigger of Chronic Inflammatory Systemic Diseases; The Timescale; The Asymptomatic Phase of Chronic Inflammatory Systemic Diseases.
- The Symptomatic Phase of Chronic Inflammatory Systemic DiseasesThe Plasticity Phase of Chronic Inflammatory Systemic Diseases in Early Life; Summary; Chapter II: Pathogenesis and Neuroendocrine Immunology; Historical Remarks; Physiological Basis; Receptors for Hormones and Neurotransmitters on Immune Cells; Dual Roles of Hormones and Neurotransmitters/Neuropeptides; Availability of Hormones and Neurotransmitters/Neuropeptides in the Tissue; Switching on the Systemic Response Systems; Differential Activation and Inhibition of Response Systems.
- Influence of Hormones and Neurotransmitters/Neuropeptides on Immune FunctionEndocrine Immune Relations in Chronic Inflammatory Systemic Diseases; Inadequate Secretion of Cortisol Relative to Inflammation; The Link Between TNF and Hormone Axes; The Possible Role of Adrenal Mitochondria in the Relative Decrease of Adrenal Steroid Secretion During Inflammation; The Women-to-Men Preponderance in Rheumatic Diseases: The Role of Sex Hormones; Loss of Adrenal and Gonadal Androgens; Increased Conversion of Androgens to Estrogens; DHEA and the Risk of Developing a Chronic Inflammatory Systemic Disease.
- CRH in Local InflammationElevated Levels of Melatonin and Prolactin; Vitamin D Hypovitaminosis; The Hypothalamic-Pituitary-Thyroid Gland Axis; Insulin and Insulin-Like Growth Factor 1 are Proinflammatory; Insulin Resistance is a Proinflammatory Signal; Growth Hormone: Dual Roles in Adults and Children; Angiotensin II is Proinflammatory; Adipokines are Proinflammatory; Hormonal Influence on T Helper Type 17 Cells and T Regulatory Cells; Neuroimmunology in Chronic Inflammatory Systemic Diseases; Introduction ; Acute Inflammation (Phase 1: The First 12 h).