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Stellate cells in health and disease /
Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam [Netherlands] :
Academic Press,
2015.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Stellate Cells in Health and Disease; Copyright Page; Dedication; Contents; List of Contributors; Foreword; What have we learned?; The outlook for anti-fibrotic treatment; References; Preface; 1 History and Early Work; 1.1 Discovery of Hepatic Stellate Cells; 1.2 HSCs and Vitamin A Homeostasis; 1.3 Morphological Characteristics of HSCs; 1.4 HSCs and Liver Fibrosis; 1.5 Isolation and Culture of HSCs; 1.6 Activation and Transdifferentiation of HSCs; 1.7 Markers for HSCs; 1.8 Perspective; References; 2 Hepatic Stellate Cell Culture Models; 2.1 Isolation of Hepatic Stellate Cells.
- 2.2 Single Cell Culture2.3 In Vitro- Versus In Vivo-Activated HSCs; 2.4 Single Cell Culture and 2D: Importance of Adhesion, Arg-Gly-Asp, and Matrix Components; 2.5 HSC Co-Cultures with Kupffer Cells, Hepatocytes, LSEC, HCC, and CC Cells; 2.6 In Vitro 3D Culture Systems; 2.7 Conclusions; References; 3 Hepatic Fibrosis: A Global Clinical Problem; 3.1 Introduction; 3.2 Chronic Viral Hepatitis; 3.2.1 Alcohol-induced liver fibrosis; 3.3 NAFLD and NASH; 3.4 Autoimmune Hepatitis, Primary Biliary Cirrhosis, and Primary Sclerosing Cholangitis; 3.5 Etiology-Driven Liver Fibrosis; 3.5.1 Perspectives.
- 6.2.1 Contribution of HSCs to liver fibrosis6.2.1.1 HSCs/Myofibroblasts are the primary target of anti-fibrotic therapy; 6.2.1.2 Reversibility of liver fibrosis; 6.2.1.3 Inactivation of HSCs (iHSCs); 6.2.2 Other functions of HSCs; 6.2.2.1 Distinct functions of senescent HSCs; 6.2.2.2 HSC as regulatory bystanders; 6.2.2.3 HSCs as regulators of hepatocellular damage; 6.2.2.4 The role of HSCs in liver regeneration; 6.3 Portal Fibroblasts; 6.3.1 Characterization of PFs; 6.4 Epithelial-to-Mesenchymal Transition; 6.5 Perspective; References; 7 Matrix Metalloproteinases and Their Inhibitors.