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Anti-Angiogenesis Drug Discovery and Development. Volume 2 /
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both fo...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier Ltd.,
[2014]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Anti-Angiogenesis Drug Discovery and Development Volume 2 ; Copyright ; Contents ; Preface ; List of Contributors ; Chapter 1: Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis ; Abstract ; Introduction ; An Historical Overview of Angiogenesis ; Types of Angiogenesis ; The Mechanism of Normal Angiogenesis ; Tumor Indduced Anngiogeneesis ; Assays for Angiogenesis ; Mechanism of Angiogenesis Inhibition ; Inhibitors of Growth Factors and Receptors ; An Overview of Anti-Angiogenic Therapy ; Conclusion.
- Acknowledgements Conflict of Interest ; References ; Chapter 2: Development of in vitro Method for Assaying Anti-Angiogenic Effect of Drugs ; Abstract ; Introduction ; Collagenn Gel Cullture of Aortic Eexplant ; Capillary Tube Formation ; Immunohistochemistry of Angiogenic Factors ; Adhesive Molecules (integrins) ; CD133 (Hematopoietic Stem/Progenitor Cell Marker ; Gene Array Analysis ; Anti-Angiogenic Drugs ; Collagen Gel Culture as an in vitro Model for Studyingvascular Injury ; Collagen Gel Culture of Various Organs ; Conclusion ; Acknowledgements ; Conflict of Interest ; Disclosures.
- Cconclusion Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 5: Development of Novel Anti-Cancer Strategies Based Onangiogenesis Inhibition ; Abstract ; Introduction ; Physiological Angiogenesis ; Pathological Angiogenesis ; Factors Responsible for Angiogenesis ; Molecules Involved in Angiogenesis ; Signal Transduction Pathways Involved in Angiogenesis ; Strategies for Targeting Angiogenesis ; Naturally Occurring Inhibitors ; Mimics for Angiogenesis ; Synthetic Inhibitors ; Concluding Remarks ; Acknowledgements ; Conflict of Interest ; References.
- Chapter 6: Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer Abstract ; Introduction ; Mechanisms of Action ; Resistance ; General Toxicities ; Agents Bevacizumab ; Aflibercept (VEGF Trap) ; BIBF1120 ; Additional Antiangiogenics ; MEDI3617 ; Novel Delivery of Antiangiogenics ; Limitations and Future Clinical Use ; Registration Strategies ; Combination Antivascular Therapies ; Conclusion ; Acknowledgements ; Conflict of Interest ; Competing Interests ; References ; Chapter 7: STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy? ; Abstract.