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Systems biology in toxicology and environmental health /
Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental tox...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2015.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Systems biology in toxicology and environmental health / |c edited by Rebecca C. Fry. |
| 264 | 1 | |a Amsterdam : |b Elsevier, |c 2015. | |
| 264 | 4 | |c �2015 | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed June 22, 2015). | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them. | ||
| 505 | 0 | |a Front Cover; Systems Biology in TOXICOLOGY AND ENVIRONMENTAL HEALTH; Copyright; CONTENTS; CONTRIBUTORS; PREFACE; Chapter 1 -- Systems Biology in Toxicology and Environmental Health; SYSTEMS BIOLOGY DEFINED; TECHNOLOGIES UTILIZED IN SYSTEMS BIOLOGY; APPLICATIONS OF SYSTEMS BIOLOGY IN ENVIRONMENTAL HEALTH; APPLICATIONS OF SYSTEMS BIOLOGY IN TOXICOLOGY; APPLICATIONS OF SYSTEMS BIOLOGY IN THE CLINIC; SUMMARY; REFERENCES; Chapter 2 -- The Cell: The Fundamental Unit in Systems Biology; INTRODUCTION; THE CELL: STRUCTURE AND ORGANELLES; CELLULAR SIGNALING: PLASMA MEMBRANE AND SIGNAL TRANSDUCTION. | |
| 505 | 8 | |a CELLULAR HOMEOSTASIS (I): ENERGY METABOLISMDECODING THE GENOME (I): TRANSCRIPTION; DECODING THE GENOME (II): TRANSLATION; CELLULAR HOMEOSTASIS (II): CELL DIFFERENTIATION, DEATH; REFERENCES; Chapter 3 -- Systems Biology and the Epigenome; INTRODUCTION; DNA METHYLATION; MOLECULAR BASIS OF DNA METHYLATION; POSTTRANSLATIONAL HISTONE MODIFICATIONS; CHROMATIN; REFERENCES; Chapter 4 -- Omics Technologies Used in Systems Biology; INTRODUCTION; GENOMICS; GENERATION OF MICROARRAY DATA; GENOMIC DATA GENERATION USING WHOLE TRANSCRIPTOME SHOTGUN SEQUENCING (RNA-SEQ); PROTEOMICS; METABOLOMICS; SUMMARY. | |
| 505 | 8 | |a IMMUNODEFICIENCY DISEASESAUTOIMMUNE DISEASES; IMMUNE FUNCTION AND TYPE 1 DIABETES; ENVIRONMENTAL EXPOSURES AND THEIR IMPACT ON IMMUNE-RELATED SIGNALING PATHWAYS; ARSENIC AND THE IMMUNE SYSTEM; CADMIUM EFFECTS ON THE IMMUNE SYSTEM; AIR POLLUTION AND IMMUNE FUNCTION; MERCURY; CONCLUSIONS; REFERENCES; Chapter 8 -- The Role of Apoptosis-Associated Pathways as Responders to Contaminants and in Disease Progression; INTRODUCTION TO APOPTOSIS; CANONICAL PATHWAYS THAT REGULATE APOPTOSIS INITIATION; APOPTOSIS SIGNALING PATHWAYS AND DISEASE; APOPTOSIS PATHWAYS THAT ARE ALTERED BY ENVIRONMENTAL COMPOUNDS. | |
| 650 | 0 | |a Toxicology |x Data processing. | |
| 650 | 0 | |a Environmental health. | |
| 650 | 0 | |a Systems biology. | |
| 650 | 1 | 2 | |a Systems Biology |0 (DNLM)D049490 |
| 650 | 2 | 2 | |a Toxicological Phenomena |0 (DNLM)D000069436 |
| 650 | 2 | 2 | |a Environmental Health |0 (DNLM)D004782 |
| 650 | 6 | |a Toxicologie |0 (CaQQLa)201-0054329 |x Informatique. |0 (CaQQLa)201-0380011 | |
| 650 | 6 | |a Biologie syst�emique. |0 (CaQQLa)000260964 | |
| 650 | 6 | |a Hygi�ene du milieu. |0 (CaQQLa)201-0000744 | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Systems biology |2 fast |0 (OCoLC)fst01745552 | |
| 650 | 7 | |a Environmental health |2 fast |0 (OCoLC)fst00912999 | |
| 650 | 7 | |a Toxicology |x Data processing |2 fast |0 (OCoLC)fst01153368 | |
| 700 | 1 | |a Fry, Rebecca C., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Systems biology in toxicology and environmental health. |d Amsterdam : Academic Press, [2015] |z 9780128015643 |w (DLC) 2015937703 |w (OCoLC)920534113 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128015643 |z Texto completo |
| 880 | 0 | 0 | |6 505-00/(S |g Machine generated contents note: |g 1. |t Systems Biology in Toxicology and Environmental Health / |r Rebecca C. Fry -- |t Systems Biology Defined -- |t Technologies Utilized in Systems Biology -- |t Applications of Systems Biology in Environmental Health -- |t Applications of Systems Biology in Toxicology -- |t Applications of Systems Biology in the Clinic -- |t Summary -- |t References -- |g 2. |t The Cell: The Fundamental Unit in Systems Biology / |r Rebecca C. Fry -- |t Introduction -- |t The Cell: Structure and Organelles -- |t Cellular Signaling: Plasma Membrane and Signal Transduction -- |t Cellular Homeostasis (I): Energy Metabolism -- |t Decoding the Genome (I): Transcription -- |t Decoding the Genome (II): Translation -- |t Cellular Homeostasis (II): Cell Differentiation, Death -- |t References -- |g 3. |t Systems Biology and the Epigenome / |r Susan K. Murphy -- |t Introduction -- |t DNA Methylation -- |t Molecular Basis of DNA Methylation -- |t Posttranslational Histone Modifications -- |t Chromatin -- |t References -- |g 4. |t Omics Technologies Used in Systems Biology / |r Susan Sumner -- |t Introduction -- |t Genomics -- |t Generation of Microarray Data -- |t Genomic Data Generation Using Whole Transcriptome Shotgun Sequencing (RNA-Seq) -- |t Proteomics -- |t Metabolomics -- |t Summary -- |t References -- |g 5. |t Computational Methods Used in Systems Biology / |r David M. Reif -- |t Introduction -- |t Study Design for Systems Biology -- |t Genetics -- |t Epigenomics -- |t Transcriptomics -- |t Proteomics -- |t Metabolomics -- |t Integration into a Systems Framework -- |t Summary -- |t References -- |g 6. |t Priority Environmental Contaminants: Understanding Their Sources of Exposure, Biological Mechanisms, and Impacts on Health / |r Rebecca C. Fry -- |t Introduction -- |t Top 10 Compounds from the ATSDR 2013 Priority List of Hazardous Substances -- |t Carcinogenic, Organic Hazardous Air Pollutants -- |t Environmental Contaminants of Emerging Concern -- |t Conclusions -- |t References -- |g 7. |t Environmental Contaminants and the Immune System: A Systems Perspective / |r Rebecca C. Fry -- |t Introduction: What is the Immune System-- |t Innate versus Adaptive or Acquired Immunity -- |t Leukocytes: Cells of the Immune System -- |t Cytokines, Chemokines, and Chemotaxis -- |t How Is the Immune System Linked to Inflammation-- |t Signaling Pathways that Regulate the Immune System -- |t IFNγ Regulation of Immune Function -- |t TGFβ and Immune Function -- |t NFκB Signaling and the Immune System -- |t TNF Regulation of Immune Function -- |t The Role of MAPK Proteins, JNK and p38 in the Immune Response -- |t The Immune System and Disease States -- |t Immunodeficiency Diseases -- |t Autoimmune Diseases -- |t Immune Function and Type 1 Diabetes -- |t Environmental Exposures and their Impact on Immune-Related Signaling Pathways -- |t Arsenic and the Immune System -- |t Cadmium Effects on the Immune System -- |t Air Pollution and Immune Function -- |t Mercury -- |t Conclusions -- |t References -- |g 8. |t The Role of Apoptosis-Associated Pathways as Responders to Contaminants and in Disease Progression / |r Julia E. Rager -- |t Introduction to Apoptosis -- |t Canonical Pathways that Regulate Apoptosis Initiation -- |t Apoptosis Signaling Pathways and Disease -- |t Apoptosis Pathways that Are Altered by Environmental Compounds -- |t Conclusions -- |t References -- |g 9. |t Systems Biology of the DNA Damage Response / |r William K. Kaufmann -- |t Introduction -- |t DNA Damage and its Responses -- |t The Systems Biology Mantra -- |t Mapping the DDR Network in Yeast -- |t The Systems Biology of Human Cell Response to DNA Double-Strand Breaks -- |t Comparison of Yeast and Human Systems of Response to DNA Damage -- |t References -- |g 10. |t Hormone Response Pathways as Responders to Environmental Contaminants and Their Roles in Disease / |r Rebecca C. Fry -- |t Introduction: Overview of the Endocrine System -- |t Hormone Response Pathways -- |t Health Effects of Hormone Pathway Dysregulation -- |t Environmental Contaminants and Hormone Response Pathways -- |t Conclusions -- |t References -- |g 11. |t Developmental Origins of Adult Disease: Impacts of Exposure to Environmental Toxicants / |r Kathryn A. Bailey -- |t Introduction -- |t Developmental Origins of Health and Disease: Adverse Environmental Conditions in Early Life and Latent Health Effects -- |t Early-Life Toxicant Exposure: Latent Health Effects and Epigenetic Alterations -- |t Conclusions and Future Directions -- |t References. |