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Epigenetic technological applications /

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest de...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Zheng, Y. George (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, [2015]
Colección:Translational epigenetics series.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • The state of the art of epigenetic technologies
  • Technologies for the measurement and mapping of genomic 5-methylcytosine and 5-hydroxymethylcytosine
  • High-throughput sequencing-based mapping of cytosine modifications
  • Application of mass spectrometry in translational epigenetics
  • Techniques analyzing chromatin modifications at specific single loci
  • Comprehensive analysis of mammalian linker-histone variants and their mutants
  • Crystallography-based mechanistic insights into epigenetic regulation
  • Chemical and genetic approaches to study histone modifications
  • Peptide microarrays for profiling of epigenetic targets
  • Current methods for methylome profiling
  • Bioinformatics and biostatistics in mining epigenetic disease markers and targets
  • Computational modeling to elucidate molecular mechanisms of epigenetic memory
  • DNA methyltransferase inhibitors for cancer therapy
  • Histone acetyltransferases: enzymes, assays, and inhibitors
  • In vitro histone deacetylase activity screening: making a case for better assays
  • Enzymatic assays of histone methyltransferase enzymes
  • Histone methyltransferase inhibitors for cancer therapy
  • Discovery of histone demethylase inhibitors
  • Histone demethylases: background, purification, and detection
  • Animal model study of epigenetic inhibitors
  • Index.