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The protective arm of the renin angiotensin system (RAS) : functional aspects and therapeutic implications /
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin-angiotensin system (RAS), providing readers with early insight into a complex system which will bec...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK :
Academic Press,
2015.
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| Edición: | First edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications; Copyright; Contents; Contributors; Chapter 1: The Angiotensin AT 2 Receptor: From Enigma to Therapeutic Target ; Introduction; References; Chapter 2: The AT 2 Receptor: Historical Perspective ; Background to the Early Involvement of Ciba-Geigy in the Angiotensin Field; Two Ang II Receptor Subtypes; Angiotensin II Receptor Nomenclature; Early Research on the Role of the AT 2 Receptor; Conclusion; References; Chapter 3: Animal Models with a Genetic Alteration of AT 2 Expression.
- IntroductionBlood Pressure; Cardiac Disease; Vascular Disease; Renal Disease; Neural Disease; Conclusion; References; Chapter 4: AT 2 Receptor Signaling: Solved and Unsolved; Introduction; AT 2 R Dimerization; Proliferation and Differentiation; Apoptosis; Inflammation; Fibrosis; Solved and Unsolved Issues; References; Chapter 5: AT 1 R
- AT 2 R Cross Talk; Cross Regulation of Angiotensin II Type 1 Receptor and the Angiotensin II Type 2 Receptor; Functional Significance of the AT 1 R
- AT 2 R Cross Talk; Conclusion; References; Chapter 6: The Angiotensin AT 2 Receptor in Myocardial Infarction.
- IntroductionAT 2 Receptor Expression in the Heart; Acute-Phase Postmyocardial Infarction; Cardiac Function; Bradykinin/Nitric Oxide System; Intracellular Acidosis; Apoptosis; Inflammation; Tissue Regeneration; Late-Phase Postmyocardial Infarction; Cardiac Function; Cardiac Fibrosis; Cardiac Hypertrophy; Extracellular Matrix Degradation; Conclusion; References; Chapter 7: AT 2 R, Vascular Effects, and Blood Pressure; Introduction; AT 2 Vasorelaxation: In Vitro Preclinical Studies; Acute AT 2 R Vasodilatation/ BP Effects: In Vivo Preclinical Studies.
- Chronic AT 2 R Effects on BP: Preclinical StudiesHuman Vascular AT 2 R Function: Ex Vivo and In Vivo Studies; AT 2 R Vasorelaxation: Why Is There no Translation into Antihypertensive Effects in Chronic Studies?; Acknowledgments; References; Chapter 8: AT 2 R in Nervous System; Introduction; AT 2 R Expression in CNS ; AT 2 R Expression in Neuronal Injury; AT 2 R -Mediated Effects in CNS Cells; AT 2 R in Peripheral Neuronal Injury; AT 2 R Stimulation in Stroke; AT 2 R in Spinal Cord Injury; AT 2 R in Multiple Sclerosis; AT 2 R in Traumatic Brain Injury; Conclusion; References.
- Chapter 9: Roles of AT 2 R in Cognitive FunctionIntroduction; Preventive Effects of ARB on Cognitive Decline and Dementia; Protection Against Ischemic Brain Damage by AT 2 R Stimulation; Role of AT 2 R Stimulation in Cognitive Function; Role of AT 2 R-Associated Proteins in Cognitive Function; Conclusion; Acknowledgments; References; Chapter 10: The Protective Role of Angiotensin II (AT 2) Receptors in Renal Disease: Molecular Mechanisms and Indications ... ; Introduction; Renal AT 2 R Expression; Findings from AT 2 R Knockout (AT 2 KO) Mice; AT 2 R -Mediated Signaling Pathways.