Principles of translational science in medicine : from bench to bedside /

Mostrar otras versiones (1)

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Wehling, Martin (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, [2015]
Edición:Second edition.
Temas:
Medical innovations.
Clinical medicine.
Biomedical Research
Clinical Medicine
M�edecine > Innovations.
M�edecine clinique.
HEALTH & FITNESS > Holism.
HEALTH & FITNESS > Reference.
MEDICAL > Alternative Medicine.
MEDICAL > Atlases.
MEDICAL > Essays.
MEDICAL > Family & General Practice.
MEDICAL > Holistic Medicine.
MEDICAL > Osteopathy.
Clinical medicine
Medical innovations
Internet Resources.
Index not Present.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Principles of Translational Science in Medicine; Copyright; Contents; List of Contributors; Preface; Chapter 1
  • Introduction and Definitions; WHAT IS TRANSLATIONAL MEDICINE?; PRIMARY TRANSLATION VERSUS SECONDARY TRANSLATION; THE HISTORY OF TRANSLATIONAL MEDICINE, OBSTACLES, AND REMITS; WHAT TRANSLATIONAL MEDICINE CAN AND CANNOT DO; THE PRESENT STATUS OF TRANSLATIONAL MEDICINE (INITIATIVES AND DEFICIENCIES); TRANSLATIONAL SCIENCE IN MEDICINE: THE CURRENT CHALLENGE; REFERENCES; Chapter 2
  • Target Identification and Validation
  • Chapter 2.1.1
  • "Omics" Translation: A Challenge for Laboratory MedicineINTRODUCTION; "OMICS": WHAT DOES IT MEAN?; PROTEOMICS AS A PARADIGM OF PROBLEMS IN TRANSLATIONAL MEDICINE; DEVELOPMENT OF BIOMARKERS: FROM DISCOVERY TO CLINICAL APPLICATION; DISCOVERY; IDENTIFICATION/CHARACTERIZATION; VALIDATION; STANDARDIZATION/HARMONIZATION; CLINICAL ASSOCIATION AND CLINICAL BENEFIT; TRANSLATING OMICS INTO CLINICAL PRACTICE; CONTINUUM OF TRANSLATION RESEARCH AND OMICS; CONCLUSIONS; REFERENCES; Chapter 2.1.2
  • "Omics" Technologies: Promises and Benefits for Molecular Medicine; INTRODUCTION; GENOMICS
  • METABOLOMICSCONCLUSION; REFERENCES; Chapter 2.1.3
  • Potency Analysis of Cellular Therapies: The Role of Molecular Assays; POTENCY TESTING; COMPLEXITIES ASSOCIATED WITH POTENCY TESTING OF CELLULAR THERAPIES; FACTORS AFFECTING THE POTENCY OF CELLULAR THERAPIES; MEASURING POTENCY OF CELLULAR THERAPIES; GENE EXPRESSION ARRAYS FOR POTENCY TESTING; POTENTIAL APPLICATIONS OF GENE EXPRESSION PROFILING FOR POTENCY TESTING; MICRORNAS AS POTENCY ASSAYS; CONCLUSIONS; REFERENCES; Chapter 2.1.4
  • Translational Pharmacogenetics to Support Pharmacogenetically Driven Clinical Decision Making; INTRODUCTION
  • PHARMACOGENETICS AS A TOOL FOR IMPROVING INDIVIDUAL DRUG THERAPYTYPES OF DRUG THERAPIES THAT MIGHT PROFIT FROM PHARMACOGENETIC DIAGNOSTICS; THE STATUS OF TRANSLATIONAL PHARMACOGENETICS IN VARIOUS DRUG THERAPY FIELDS; TRANSLATIONAL PHARMACOGENETICS AND THE NEED FOR CLINICAL STUDIES TO SUPPORT PHARMACOGENETICALLY DRIVEN PRESCRIBING; REFERENCES; Chapter 2.1.5
  • Tissue Biobanks; INTRODUCTION; PRINCIPLES AND TYPES OF TISSUE BIOBANKS: PROS AND CONS; DEVELOPMENTS IN VASCULAR BIOBANKING RESEARCH AND CLINICAL RELEVANCE; CHALLENGES FOR FUTURE BIOBANKS; SUMMARY; REFERENCES
  • Chapter 2.1.6
  • Animal Models: Value and Translational PotencyWHAT IS THE VALUE OF ANIMAL MODELS? PATHOPHYSIOLOGICAL CONCEPTS; WHAT IS A GOOD ANIMAL MODEL FOR TRANSLATIONAL RESEARCH?; WHAT IS THE TRANSLATIONAL VALUE OF ANIMAL MODELS?; REMEDIES FOR FAILED TRANSLATION: IMPROVING PRECLINICAL RESEARCH; SUMMARY; REFERENCES; Chapter 2.1.7
  • Localization Technologies and Immunoassays: Promises and Benefits for Molecular Medicine; INTRODUCTION; LOCALIZATION TECHNOLOGIES; IMMUNOASSAYS; CASE STUDY: SCREENING OF A BIOMARKER FOR KIDNEY INJURY USING LOCALIZATION AND IMMUNOASSAYS; REFERENCES
  • Chapter 2.1.8
  • Biomarkers in the Context of Health Authorities and Consortia

Ejemplares similares