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Protein and Peptide Nanoparticles for Drug Delivery /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Waltham, MA :
Academic Press,
2015.
|
| Colección: | Advances in protein chemistry and structural biology ;
v. 98. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Protein and Peptide Nanoparticles for Drug Delivery; Copyright; Contents; Contributors; Preface; References; Chapter One: Protein- and Peptide-Drug Conjugates: An Emerging Drug Delivery Technology; 1. Introduction; 2. Protein-Drug Conjugates; 2.1. Albumin-drug conjugates; 2.2. Transferrin-drug conjugates; 2.3. Gelatin-drug conjugates; 2.4. Antibody-drug conjugates; 2.5. Other protein-drug conjugates; 3. Peptide-Drug Conjugates; 3.1. RGD peptide-drug conjugates; 3.2. Cell penetrating peptide-drug conjugates; 4. Strategies for Chemical Conjugation; 4.1. Linker technologies
- 4.1.1. Cleavable linkers4.1.2. Noncleavable linkers; 5. Challenges; 6. Future Perspective; 7. Conclusion; References; Chapter Two: Modifications of Natural Peptides for Nanoparticle and Drug Design; 1. Introduction; 2. Role of Nanoparticles in Peptide Drug Delivery; 3. Cell-Penetrating Peptides; 3.1. Structure and properties; 3.1.1. Cationic CPPs; 3.1.2. Amphipathic CPPs; 3.1.3. Hydrophobic CPPs; 3.2. Applications in nanoparticle delivery; 3.2.1. Tat peptide; 3.2.2. Penetratin; 3.2.3. MPG/Pep-1; 3.2.4. Antimicrobial peptides; 4. Antimicrobial Peptides; 4.1. Sequence modifications
- 4.2. Nanoparticle delivery strategies5. Peptide Toxins; 5.1. Mechanisms of action; 5.2. Therapeutic applications; 5.2.1. Amphibian toxins; 5.2.2. Bee venom; 5.2.3. Scorpion venom; 5.2.4. Snake venom; 6. Conclusion; References; Chapter Three: Hybrid Protein-Synthetic Polymer Nanoparticles for Drug Delivery; 1. Introduction; 2. Nanoparticles Derived from Polymer(s) and Covalently Bound Protein(s); 2.1. Hybrid micelles derived from copolymers of PEG and PGlu; 2.2. Hybrid nanoparticles based on (bio)degradable polyesters; 2.3. Hybrid nanoparticles based on nondegradable polymers
- 3. Hybrid Nanoparticles Based on Electrostatic Interactions Between Proteins/Peptides and Synthetic Polyelectrolytes4. Conclusions; References; Chapter Four: Efficient Delivery of Therapeutic Agents by Using Targeted Albumin Nanoparticles; 1. Introduction; 2. Albumin Nanoparticles' Fabrication Methods; 3. Albumin-Nanoparticles-Targeting Strategies; 4. Albumin Nanoparticles as a Drug Delivery Carrier; 4.1. Chemotherapeutic agents; 4.1.1. Paclitaxel; 4.1.2. Doxorubicin; 4.1.3. Other drugs; 4.2. Biological macromolecules; 5. Albumin Nanoparticles Marketed and Under Clinical Trial; 6. Conclusions