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Neural surface antigens : from basic biology towards biomedical applications /
Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functional role of surface molecules in neural development, stem cell research, and translational biomedical paradigms. With an emphasis on human and rodent model systems, this reference covers fundamentals of...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK :
Academic Press,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Neural surface antigens : |b from basic biology towards biomedical applications / |c Jan Pruszak. |
| 264 | 1 | |a London, UK : |b Academic Press, |c [2015] | |
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Neural Surface Antigens: From Basic Biology Towards Biomedical Applications; Copyright; Contents; Contributors; Foreword; Preface; Chapter 1 -- Fundamentals of Neurogenesis and Neural Stem Cell Development; 1.1 NEURULATION: FORMATION OF THE CENTRAL NERVOUS SYSTEM ANLAGE; 1.2 NEURULATION AND NEURAL TUBE FORMATION; 1.3 REGIONALIZATION OF THE MAMMALIAN NEURAL TUBE; 1.4 ONSET OF NEUROGENESIS IN THE TELENCEPHALON; 1.5 THE TRANSITION OF THE NEUREPITHELIUM TO NEURAL STEM CELLS; 1.6 PROGENITOR FATE COMMITMENT AND RESTRICTION; 1.7 MOLECULAR MECHANISMS OF NEURAL STEM CELL MAINTENANCE. | |
| 505 | 8 | |a 1.8 INTERNEURON GENERATION FROM THE VENTRAL TELENCEPHALON1.9 FORMATION OF THE CEREBRAL ISOCORTEX AND CORTICAL LAYERING; 1.10 OLIGODENDROGENESIS AND ASTROGENESIS; REFERENCES; Chapter 2 -- A Brief Introduction to Neural Flow Cytometry from a Practical Perspective; 2.1 INTRODUCTION; 2.2 WHAT IS FLOW CYTOMETRY?; 2.3 CHALLENGES AND OPPORTUNITIES OF NEURAL FLOW CYTOMETRY; 2.4 CELL SORTING OF NEURAL CELLS-STEP BY STEP; 2.5 FLOW CYTOMETRIC ANALYSIS OF NSCS; 2.6 FLOW CYTOMETRY OF NEURONS; 2.7 FLOW CYTOMETRIC ANALYSIS OF GLIAL CELL TYPES; 2.8 CONCLUSION; REFERENCES. | |
| 505 | 8 | |a Chapter 3 -- CD36, CD44, and CD83 Expression and Putative Functions in Neural Tissues3.1 INTRODUCTION; 3.2 THE PUTATIVE CD36 FUNCTIONS IN THE CNS: A MULTIFUNCTIONAL SCAVENGER RECEPTOR AND LIPID SENSOR; 3.3 THE EXPRESSION OF CD44 ADHESION MOLECULE IN NEURAL CELLS; 3.4 THE GLYCOPROTEIN CD83; 3.5 CONCLUDING REMARKS; REFERENCES; Chapter 4 -- Life and Death in the CNS: The Role of CD95; 4.1 INTRODUCTION; 4.2 CD95 EXPRESSION IN THE HEALTHY AND DISEASED BRAIN; 4.3 FUNCTIONS AND SIGNALING OF CD95 IN THE CNS; 4.4 CONCLUSIONS; REFERENCES. | |
| 505 | 8 | |a Chapter 5 -- Role of Fundamental Pathways of Innate and Adaptive Immunity in Neural Differentiation: Focus on Toll-like Receptors, Complement System, and T-Cell-Related Signaling5.1 MOLECULES FROM INNATE IMMUNITY; 5.2 MOLECULES FROM ADAPTIVE IMMUNITY; 5.3 CONCLUSION; REFERENCES; Chapter 6 -- Neuropilins in Development and Disease of the Nervous System; 6.1 INTRODUCTION; 6.2 NEUROPILINS ASSOCIATE WITH PLEXINS TO MEDIATE SEMAPHORIN SIGNALING; 6.3 NEUROPILINS AND PLEXINS COOPERATE TO CONFER SPECIFICITY TO SEMAPHORIN SIGNALING; 6.4 NEUROPILIN-MEDIATED REPULSION IN AXON GUIDANCE. | |
| 505 | 8 | |a 6.5 neuropilins can mediate attractive responses by axons to semaphorins6.6 neuropilins organize axon projections to provide a substrate for migrating neurons; 6.7 semaphorin signaling through neuropilins in neurons promotes neuronal migration; 6.8 vegf-a as an alternative neuropilin ligand in the nervous system; 6.9 differential vegf-a isoform affinity for the two neuropilins; 6.10 vegf-a signaling through neuropilin 1; 6.11 nrp1 in cns angiogenesis; 6.12 vegf-a/nrp1 signaling promotes contralateral axon projection across the optic chiasm. | |
| 520 | |a Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functional role of surface molecules in neural development, stem cell research, and translational biomedical paradigms. With an emphasis on human and rodent model systems, this reference covers fundamentals of neural stem cell biology and flow cytometric methodology. Addressing cell biologists as well as clinicians working in the neurosciences, the book was conceived by an international panel of experts to cover a vast array of particular surface antigen families and subtypes. It provides insight into the basic biology and functional mechanisms of neural cell surface signaling molecules influencing mammalian development, regeneration, and treatments. Introduces early phase clinical trials of neural stem cells Outlines characterization of surface molecule expression and methods for isolation which open unprecedented opportunities for functional study, quantitation & diagnostics Highlights the role of stem cells in neural surface antigen and biomarker analysis and applications. | ||
| 650 | 0 | |a Antigens. | |
| 650 | 0 | |a Flow cytometry. | |
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| 650 | 2 | 2 | |a Neural Stem Cells |x physiology |0 (DNLM)D058953Q000502 |
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| 776 | 0 | 8 | |i Print version: |a Pruszak, Jan. |t Neural Surface Antigens : From Basic Biology Towards Biomedical Applications. |d Burlington : Elsevier Science, �2015 |z 9780128007815 |w (DLC) 2014946713 |w (OCoLC)871330337 |
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