Circadian rhythms and biological clocks. Volume 552, Part B /

Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key ele...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Sehgal, Amita (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands : Elsevier Academic Press, 2015.
Colección:Methods in enzymology ; v. 552.
Temas:
Circadian rhythms > Handbooks, manuals, etc.
Biological rhythms > Handbooks, manuals, etc.
Circadian rhythms.
Circadian Rhythm
Rythmes circadiens > Guides, manuels, etc.
Rythmes circadiens.
SCIENCE > Life Sciences > Biochemistry.
Biological rhythms
Circadian rhythms
Handbook
handbooks.
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Acceso en línea:Texto completo
Texto completo
Texto completo
Tabla de Contenidos:
  • pt. I Dissecting the Central Clock Circuit
  • 1. Measuring Synchrony in the Mammalian Central Circadian Circuit / Cristina Mazuski
  • 1. Introduction
  • 2. Monitoring SCN Rhythms with Cellular Resolution
  • 3. Isolating Data from Single Cells
  • 4. Defining a Rhythm
  • 5. Period Synchrony: Methods to Extract and Compare Periods Between Cells
  • 6. Phase Synchrony: Methods to Extract and Compare Phase Relationships Between Cells
  • 7. Perturbations Reveal Synchronization Mechanisms
  • 8. Methods Awaiting Application in Circadian Biology
  • 9. Step-by-Step Instructions for Measuring Synchrony in SCN Slice
  • Acknowledgments
  • References
  • 2. Patch-Clamp Electrophysiology in Drosophila Circadian Pacemaker Neurons / Ravi Allada
  • 1. The Drosophila Circadian Network
  • 2. Circadian Control of Neuronal Activity
  • 3. Methods for Patch-Clamp Electrophysiology
  • 4. Conclusion
  • Acknowledgments
  • References
  • 3. Glial Cell Regulation of Rhythmic Behavior / Yanmei Huang
  • 1. Introduction
  • 2. Studies of Glial Cell Function in Circadian Behavior and Sleep
  • 3. Potential Circadian Glia
  • Neuron Signaling Molecules
  • 4. Molecular Genetic Strategies for Studying the Glial Regulation of Drosophila Rhythms 59
  • Appendix A. Protocol for TRAP Profiling of Fly Glial Cells
  • References
  • 4. Neurophysiological Analysis of the Suprachiasmatic Nucleus: A Challenge at Multiple Levels / Stephan Michel
  • 1. Introduction
  • 2. Part I: Clock Mechanisms at the Cellular Level
  • 3. Part II: The SCN as a Multi-Oscillator
  • 4. Part III: In Vivo Electrophysiology Recordings from the SCN in Anesthetized and Freely Moving Animals
  • 5. Conclusions
  • Acknowledgments
  • References
  • pt. II Entrainment of Central and Peripheral Clocks
  • 5. Photic Entrainment in Drosophila Assessed by Locomotor Activity Recordings / Charlotte Helfrich-Forster
  • 1. Introduction
  • 2. Different Light Regimes Used to Entrain Locomotor Activity of Fruit Flies
  • 3. Methods to Measure Locomotor Activity
  • 4. Data Analysis and System Comparison
  • References
  • 6. Photic Regulation of Clock Systems / Stuart N. Peirson
  • 1. Introduction
  • 2. The Suprachiasmatic Nuclei
  • 3. The Molecular Circadian Clock
  • 4. Peripheral Clocks
  • 5. Photoentrainment and Melanopsin
  • 6. Entrainment of the Molecular Clock
  • 7. Molecular Photoentrainment
  • 8. Studying the Effects of Light on the Circadian Clock
  • 9. Conclusions
  • Acknowledgments
  • References
  • 7. Response of Peripheral Rhythms to the Timing of Food Intake / Satchidananda Panda
  • 1. Introduction
  • 2. Animal Strain and Age
  • 3. Animal Room and Equipment
  • 4. Facilities to Accommodate Feeding Schedule
  • 5. Diet
  • 6. Monitoring Eating Pattern
  • 7. Physiological Readout of Eating Pattern
  • 8. Feeding Paradigms
  • 9. Mouse Tissue Collection
  • 10. Transcript, Protein, and Metabolome Expression Analysis
  • 11. Conclusion
  • References
  • pt. III Clocks and Metabolic Physiology
  • 8. Circadian Regulation of Cellular Physiology / J. Bass
  • 1. Introduction
  • 2. Materials
  • 3. Methods
  • 4. Notes
  • Acknowledgments
  • References
  • 9. Analysis of the Redox Oscillations in the Circadian Clockwork / Akhilesh B. Reddy
  • 1. Introduction: Circadian and Redox Coupling in the Cell
  • 2. The Biochemical Properties of the Peroxiredoxin System
  • 3. Analysis of PRX Redox Oscillations
  • Acknowledgments
  • References
  • 10. Clocks and Cardiovascular Function / Garret A. FitzGerald
  • 1. Introduction
  • 2. Circadian Analysis of Physiological Parameters with Radiotelemetry
  • 3. Primary Cell Culture of Macrophages
  • 4. Circadian Variation in Thrombogenesis
  • 5. Atherosclerosis and Vascular Integrity in Models of Clock Disruption
  • 6. Clocks and Myocardial Dysfunction
  • 7. Conclusion
  • References
  • pt. IV Circadian Rhythms in Humans
  • 11. Measuring Circadian Clock Function in Human Cells / Steven A. Brown
  • 1. Introduction
  • 2. Studies of Circadian Clock Properties Using Reporters
  • 3. Ex Vivo and In Vitro Studies of Human Circadian Clocks
  • 4. Similar Technologies to Study Other Major Signaling Pathways
  • 5. Cell-Based Approaches to Study Gene Expression Variation and Human Interindividual Differences in Drug Responses
  • 6. Promise of In Vitro Gene Expression Profiling
  • 7. Specific Protocols
  • 8. Perspectives
  • Acknowledgments
  • References
  • 12. Human Activity and Rest In Situ / Eva C. Winnebeck
  • 1. Introduction
  • 2. Probing Activity and Sleep by Questionnaires
  • 3. Measuring Activity and Sleep by Actimetry
  • 4. Concluding Remarks
  • References
  • 13. Phenotyping of Neurobehavioral Vulnerability to Circadian Phase During Sleep Loss / David F. Dinges
  • 1. Prevalence and Consequences of Sleep Loss
  • 2. Sleep-Wake and Circadian Regulation: Two-Process Model
  • 3. Subjective and Objective Measures for Circadian Variation in Performance
  • 4. Circadian Variation Assessment in Neurobehavioral Functions
  • 5. Sleep Deprivation and Performance
  • 6. Cumulative Effects on Performance from Chronic Sleep Restriction
  • 7. Phenotypic Individual Differences in Response to Sleep Deprivation
  • 8. The PVT: Example of a Behavioral Assay for Phenotyping Responses to Sleep Loss
  • 9. Conclusions
  • Acknowledgments
  • References
  • 14. Genetics of Human Sleep Behavioral Phenotypes / Ying-Hui Fu
  • 1. Introduction
  • 2. Clinical Phenotyping
  • 3. Identification of Associated Genetic Variants
  • 4. Modeling Human Sleep Phenotypes in Rodents
  • 5. Concluding Remarks
  • Acknowledgments
  • References
  • 15. Sleep and Circadian Rhythm Disruption and Recognition Memory in Schizophrenia / Stuart N. Peirson
  • 1. Introduction
  • 2. Sleep and Circadian Rhythm Disruption in Schizophrenia
  • 3. Recognition Memory Deficits in Schizophrenia
  • 4. Recognition Memory Deficits After the Direct Manipulation of Sleep and Circadian Rhythms
  • 5. Dual-Process Theory of Recognition
  • 6. Which is Impaired, Recollection or Familiarity?
  • 7. Is There an Association Between Sleep and Circadian Function and Recognition Memory in Schizophrenia?
  • 8. Summary of the Chapter and Some Unresolved Issues
  • Acknowledgments
  • References.

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