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Neural crest and placodes /
Neural Crest and Placodes provides in-depth coverage of the topic, including information on their critical role in vertebrate development, evolution, and the way defects in their development underlie a wide range of congenital disorders. It delves deep into advances made in our understanding of the...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press, an imprint of Elsevier,
2015.
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| Edición: | First edition. |
| Colección: | Current topics in developmental biology ;
v. 111. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Neural Crest and Placodes; Copyright; Contents; Contributors; Preface; Section A: Neural Crest Cells; Chapter 1: Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell; 1. Introduction; 2. Defining Neural Crest Cells; 3. Chordate Evolution and Vertebrate Origins; 4. Neural Crest Cell Origin; 5. Neural Crest Cell Evolution in Vertebrates; 6. Cranial Neural Crest Cell Gene Regulatory Network; 7. Evolution of Neural Crest Cell Gene Regulatory Networks; 8. Conclusions and Perspectives; Acknowledgments; References.
- Chapter 2: Resolving Time and Space Constraints During Neural Crest Formation and Delamination1. Integrating Space During NCC Induction and Specification: Roles of Cell Movements and Cadherin-Mediated Cell Sorting; 2. Coordinating NCC Delamination Timely and Spatially: Regulation of Cadherin Activity; 3. Coordinating NCC Specification and Delamination: Spatiotemporal Control of the Core EMT Regulatory Factors; 3.1. Transcriptional and translational controls of the expression of the core EMT regulatory factors; 3.2. Epigenetic control of the expression of the core EMT regulatory factors.
- 3.3. Control of the stability and intracellular location of the core EMT regulatory factors3.4. Control of the activity of the core EMT regulatory factors; 4. Spatial Control of the Activity of the Zeb-2 Transcription Factor; 5. Future Prospects; Acknowledgments; References; Chapter 3: Extended Multipotency of Neural Crest Cells and Neural Crest-Derived Cells; 1. Introduction; 2. Postmigratory NCSC: Multipotent Cells are Maintained in the Tissues; 3. Cultured NCSC-Like Cells Originating from the Hair Follicle and Dermis; 4. Retention of Multipotency in Differentiated NCC-Derived Cells.
- 4.1. Plasticity of NCC-derived glial cells4.2. Plasticity of glial cells plays a significant role in embryogenesis; 4.3. Plasticity of lineage-restricted melanocytes or their precursors; 5. Maintained Multipotency in Postmigrating NCC and NCC Derivatives; 5.1. Multipotency of NC-derived lineage-restricted melanoblasts; 5.2. Duration of the multipotency of NCC-derived cells after delamination from the neural tube; 6. Remarks on the Origin of Melanomas; 7. Concluding Remarks; Acknowledgments; References; Chapter 4: The Ciliary Baton: Orchestrating Neural Crest Cell Development; 1. Introduction.
- 2. The Primary Cilium: Defining the Organelle2.1. Structure equals function; 2.2. Widespread and dynamic; 2.3. Ciliogenesis: Building the cilium; 3. The Role of Primary Cilia during NCC Ontogeny; 3.1. Primary cilia and NCC specification; 3.2. Primary cilia and NCC migration; 3.3. Primary cilia and NCC proliferation; 3.4. Primary cilia and NCC differentiation; 4. Craniofacial Phenotypes in Animal Models and Human Patients Support a Role for Primary Cilia in NCC Development; 4.1. Insights from animal models; 4.2. Human craniofacial ciliopathies.