Nonviral vectors for gene therapy lipid- and polymer-based gene transfer /

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. <i>Advances in Genetics</i> continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disc...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Huang, Leaf (Editor ), Liu, Dexi (Editor ), Wagner, Ernst, 1960- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier/Academic Press, 2014.
Colección:Advances in genetics ; v. 88.
Temas:
Genetic vectors.
Gene therapy.
Vecteurs de clonage.
Th&#xFFFD;erapie g&#xFFFD;enique.
SCIENCE > Chemistry > Industrial & Technical.
TECHNOLOGY & ENGINEERING > Chemical & Biochemical.
Gene therapy
Genetic vectors
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Front Cover; Advances in Genetics Nonviral Vectors for Gene Therapy; Copyright; DEDICATION; CONTENTS; CONTRIBUTORS; Chapter 1
  • Nonviral Vectors: We Have Come a Long Way; 1. INTRODUCTION; 2. CHEMICAL METHODS; 3. PHYSICAL METHODS; 4. PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 2
  • Lipid Nanoparticles for Gene Delivery; 1. INTRODUCTION; 2. RATIONAL DESIGNS TO OVERCOME EXTRACELLULAR AND INTRACELLULAR BARRIERS; 3. CURRENT LIPIDIC VECTORS FOR GENE DELIVERY; 4. GENE THERAPY APPLICATIONS; 5. PHARMACOKINETICS, BIODISTRIBUTION AND TOXICITY OF LNPS; 6. CLINICAL TRIALS; 7. CONCLUSIONS.
  • ACKNOWLEDGMENTSREFERENCES; Chapter 3
  • Nanotechnology for In vivo Targeted siRNA Delivery; 1. RNA POTENTLY MODIFIES GENE EXPRESSION; 2. TARGETING STRATEGIES; 3. TARGETING THE LIVER; 4. TARGETING PRIMARY TUMORS AND METASTASIS; 5. ENDOTHELIAL CELL TARGETING; 6. FUTURE PERSPECTIVES; REFERENCES; Chapter 4
  • Lipid Nanoparticles for Short Interfering RNA Delivery; 1. INTRODUCTION; 2. CHALLENGES AND STRATEGIES FOR DELIVERY OF SIRNA; 3. LIPID-BASED DELIVERY SYSTEMS; 4. LNP-SIRNA FORMULATIONS IN CLINICAL TRIALS; 5. FUTURE PROSPECTS; REFERENCES; Chapter 5
  • Composite Nanoparticles for Gene Delivery.
  • 1. NANOMEDICINE AND GENE THERAPY2. COMPOSITE NANOPARTICLES; 3. FABRICATION METHODS OF COMPOSITE NANOPARTICLES; 4. COMPOSITE NANOPARTICLES FOR TARGETED GENE DELIVERY; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 6
  • Multifunctional Enveloped Nanodevices (MENDs); 1. INTRODUCTION; 2. R8-MEND; 3. KALA-MEND; 4. MITO-PORTER; 5. YSK-MEND; 6. SS-CLEAVABLE PROTON-ACTIVATED LIPID-LIKE MATERIAL (SSPALM); 7. PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 7
  • Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy.
  • 1. RECENT PROGRESS OF NONVIRAL GENE THERAPY AND IN VITRO/IN VIVO DELIVERY SYSTEMS2. LCP NANOPARTICLES AS A MULTIFUNCTIONAL PLATFORM FOR GENE DELIVERY; 3. POTENTIAL THERAPEUTIC APPLICATIONS OF LCP: CANCER, CHRONIC LIVER DISEASE, AND GENE THERAPY; 4. LCP NANOPARTICLES: CONCLUSIONS; REFERENCES; Chapter 8
  • Polymers for Nucleic Acid Transfer-An Overview; 1. FIVE DECADES IN POLYPLEXES: CHALLENGES AND BREAKTHROUGHS; 2. OPTIMIZING THE CORE: BIODEGRADABLE AND BIOCOMPATIBLE POLYMERS; 3. OPTIMIZING THE SHELL: BIOINSPIRED SMART POLYPLEXES; 4. NEXT STEPS: MULTIFUNCTIONAL AND SEQUENCE-DEFINED POLYMERS.
  • 5. PERSPECTIVESREFERENCES; Chapter 9
  • Recent Developments in Nucleic Acid Delivery with Polyethylenimines; 1. INTRODUCTION; 2. MECHANISM OF PEI-MEDIATED DNA TRANSFECTION; 3. PROTON SPONGE: MYTH OR REALITY?; 4. PEI FOR GENE DELIVERY; 5. PEI DERIVATIVES FOR THE DELIVERY OF EXON SKIPPING OLIGONUCLEOTIDES; 6. PEIS FOR SIRNA DELIVERY; 7. CONCLUSION; REFERENCES; Chapter 10
  • Bioresponsive Polymer-Based Nucleic Acid Carriers; 1. INTRODUCTION; 2. POLYMER SELF-ASSEMBLIES FOR NUCLEIC ACID DELIVERY; 3. REDUCTIVE ENVIRONMENT-RESPONSIVE NUCLEIC ACID DELIVERY.

Ejemplares similares