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Cannabinoids in neurologic and mental disease /
The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neur...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier Inc.,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Cannabinoids in Neurologic and Mental Disease
- Copyright Page
- Contents
- Preface
- List of Contributors
- The ever-expanding world of the endocannabinoids: A concise introduction
- The Endocannabinoid System: Discovery and Early Definitions
- Cannabinoids
- Cannabinoid Receptors
- Endocannabinoids
- Specific and Less Specific Metabolic Routes and Trafficking Mechanisms for Endocannabinoids
- Redundancy and Complexity in Endocannabinoid Targets and Metabolic Enzymes
- Endocannabinoid-Related Mediators and their Targets
- Conclusions: the "Endocannabinoidome" and How to Manage it
- References
- 1 Role of the endocannabinoids in neuroinflammatory and neurodegenerative disorders
- 1 Cannabinoids for the treatment of neuroinflammation
- Neuroinflammation
- Endocannabinoid System Elements in Glial Cells
- Glial Functions and Their Modulation by Cannabinoids
- Astrocyte Functions
- Microglial Functions
- Production and release of cytotoxic molecules
- Migration
- Proliferation and phagocytosis
- Concluding Remarks
- Acknowledgments
- References
- 2 Endocannabinoids and Alzheimer's disease
- Introduction
- Alzheimer's Disease
- The Endocannabinoid System as a Therapeutic Target
- The Endocannabinoid System in Alzheimer's Disease
- Cannabinoids and Neuroinflammation
- Cannabinoids and Oxidative Stress
- Cannabinoids and Excitotoxicity
- Cannabinoids and Neurogenesis
- Conclusions
- References
- 3 Cannabinoids in Parkinson's disease
- Parkinson's Disease
- The Endocannabinoid System in the Normal Basal Ganglia
- Endocannabinoid System Dysregulation in PD
- Clinical Trials of Cannabinoid Drugs in PD Patients
- Potential of the Endocannabinoid System as a Target for Alleviation of Motor Symptoms
- Potential of the Endocannabinoid System as a Target for Alleviation of Drug-Induced Side Effects.
- Endocannabinoid Signaling in ALS
- Treatments with Cannabinoids in Preclinical Models of ALS
- Treatments with Cannabinoids in Clinical Studies with ALS Patients
- Concluding Remarks and Future Perspectives
- Acknowledgments
- References
- 6 Endocannabinoids and epilepsy
- Introduction
- ECS Regulates Excitatory Neuronal Synaptic Transmission
- Alterations in the ECS in Seizures and Epilepsy
- Reorganization of CB1 Receptor Expression and Function in Pilocarpine-Induced Temporal Lobe Epilepsy
- Other Experimental Findings
- Alterations in the ECS in Human Temporal Lobe Epilepsy
- Do Alterations in CB1 Receptors within the IML of the Dentate Gyrus Contribute to TLE?
- Therapeutic Potential of Modulating the ECS in Seizures and Epilepsy
- The Phytocannabinoids
- Targeting CB1 Receptors in Seizures and Epilepsy
- CB1 Receptor Agonists in Adjunctive AED Therapy
- Targeting Endocannabinoid Degradation for Seizure Control
- CB1 Receptor Antagonism as a Prophylactic Treatment for Seizures and Epilepsy
- ECS Interaction with Other Brain Systems in Seizure and Epilepsy
- Cannabinoid-Based Medicines: Implications for their Prolonged use in Clinical Seizures and Epilepsy
- Conclusion and Future Directions
- Acknowledgments
- References
- 7 Endocannabinoids and migraine
- Endocannabinoid System and Migraine
- Migraine Pathogenesis
- Cortical Spreading Depression
- Endocannabinoids and Migraine
- Clinical Data
- Experimental Data
- Studies with neurovascular models of migraine
- Model of Nitroglycerin
- Studies with Electrical Dural Stimulation and Cutaneous Facial Receptive Field Activation of the Ophthalmic Division of the ...
- Studies with vascular models of migraine
- Effect of Cannabinoid Receptor Activation on Cortical Spreading Depression
- Potential Sites and Mechanisms of Action of ECs.