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Carbonic anhydrases as biocatalysts : from theory to medical and industrial applications /
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing in...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Carbonic anhydrases as biocatalysts : |b from theory to medical and industrial applications / |c edited by Claudiu T. Supuran, Giuseppina De Simone. |
| 264 | 1 | |a Amsterdam : |b Elsevier, |c [2015] | |
| 264 | 4 | |c �2015 | |
| 300 | |a 1 online resource : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed January 21, 2015). | |
| 520 | |a Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. | ||
| 505 | 0 | |a Cover; Title Page; Copyright Page; Table of contents; List of Contributors; Preface; Part 1 -- Introduction; Chapter 1 -- Carbonic Anhydrases: An Overview; 1.1 -- Carbonic anhydrase families; 1.2 -- Catalytic features; 1.3 -- CA inhibition and activation; 1.4 -- Biomedical applications of the CAs; 1.5 -- Biotechnological applications of the CAs; References; Part 2 -- Carbonic Anhydrasesas Drug Targets; Chapter 2 -- Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution; 2.1 -- Introduction; 2.2 -- hCAs' structural features; 2.3 -- hCAs' catalytic features. | |
| 505 | 8 | |a 2.4 -- hCAs' tissue distribution and their role as drug targetsReferences; Chapter 3 -- Carbonic Anhydrase I; 3.1 -- Introduction; 3.2 -- Structure of CA I; 3.3 -- Tissue localization and physiological functions; 3.4 -- CA I as pharmacological target; 3.5 -- CA I inhibitors; 3.6 -- CA I activators; 3.7 -- Conclusions and perspectives; Acknowledgment; References; Chapter 4 -- Carbonic Anhydrase II as Target for Drug Design; 4.1 -- Introduction; 4.2 -- Biochemical properties, genetic relationship with the other cytosolic isoforms, and 3D structure of hCA II; 4.3 -- hCA II inhibitors. | |
| 505 | 8 | |a 4.4 -- Antiglaucoma agents4.4.1 -- First-generation inhibitors; 4.4.2 -- Second-generation inhibitors: topically acting sulfonamides; 4.4.3 -- Third-generation inhibitors; 4.4.4 -- Dithiocarbamates and xanthates as topically acting antiglaucoma CAIs targeting hCA II; 4.5 -- Diuretics with CA inhibitory properties; 4.6 -- Agents for the management of altitude sickness; 4.7 -- Various pharmacological actions connected with CA II inhibition: serendipity or off-targeting with impressive efficacy?; 4.8 -- CA II inhibitors in the management of tumors? | |
| 505 | 8 | |a 4.9 -- New strategies to design CA II-selective inhibitors4.10 -- CA II activation; 4.11 -- Conclusions; References; Chapter 5 -- Carbonic Anhydrase III; 5.1 -- Introduction; 5.2 -- Discovery of CA III; 5.3 -- Physiological role of CA III; 5.4 -- Molecular characterization of CA III; 5.5 -- Catalytic properties and proton transfer of CA III; 5.6 -- CA III as a biomarker: role in disease states; 5.7 -- CA III as a drug target; Acknowledgment; References; Chapter 6 -- Carbonic Anhydrase IV; 6.1 -- Introduction; 6.2 -- Genomic organization and chromosomal localization of human CA IV. | |
| 505 | 8 | |a 6.3 -- Cloning and molecular characterization of human CA IV6.4 -- Structure/function: the role of disulfide bonds; 6.5 -- Characterization of catalytic properties of human CA IV and its inhibition by sulfonamide inhibitors; 6.6 -- Expression of CA IV in different tissues; 6.7 -- Physiological functions of CA IV; 6.7.1 -- Kidney function; 6.7.2 -- Neuronal function; 6.7.3 -- Eye function; 6.7.4 -- Skeletal and cardiac muscle function; 6.7.5 -- CA IV functions in metabolons; 6.7.6 -- The role of CA IV in the taste of carbonation; 6.7.7 -- Disease-causing mutations in CA IV; 6.7.8 -- Kidney disease. | |
| 505 | 8 | |a 6.7.9 -- Environmental factors contributing to RP-17 associated with CA IV mutations. | |
| 650 | 0 | |a Carbonic anhydrase. | |
| 650 | 0 | |a Carbonic anhydrase |x Therapeutic use. | |
| 650 | 0 | |a Enzymes. | |
| 650 | 0 | |a Enzymes |x Therapeutic use. | |
| 650 | 0 | |a Biotechnology. | |
| 650 | 2 | |a Carbonic Anhydrases |0 (DNLM)D002256 | |
| 650 | 2 | |a Enzymes |0 (DNLM)D004798 | |
| 650 | 2 | |a Biotechnology |0 (DNLM)D001709 | |
| 650 | 6 | |a Anhydrase carbonique. |0 (CaQQLa)201-0088394 | |
| 650 | 6 | |a Anhydrase carbonique |0 (CaQQLa)201-0088394 |x Emploi en th�erapeutique. |0 (CaQQLa)201-0373975 | |
| 650 | 6 | |a Enzymes. |0 (CaQQLa)201-0002557 | |
| 650 | 6 | |a Enzymes |0 (CaQQLa)201-0002557 |x Emploi en th�erapeutique. |0 (CaQQLa)201-0373975 | |
| 650 | 6 | |a Biotechnologie. |0 (CaQQLa)201-0004007 | |
| 650 | 7 | |a enzyme. |2 aat |0 (CStmoGRI)aat300212647 | |
| 650 | 7 | |a bioengineering. |2 aat |0 (CStmoGRI)aat300250623 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Biotechnology |2 fast |0 (OCoLC)fst00832729 | |
| 650 | 7 | |a Carbonic anhydrase |2 fast |0 (OCoLC)fst00846939 | |
| 650 | 7 | |a Enzymes |2 fast |0 (OCoLC)fst00913605 | |
| 650 | 7 | |a Enzymes |x Therapeutic use |2 fast |0 (OCoLC)fst00913631 | |
| 700 | 1 | |a Supuran, Claudiu T., |d 1962- |e editor. | |
| 700 | 1 | |a Simone, Giuseppina De, |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Supuran, Claudiu T. |t Carbonic Anhydrases as Biocatalysts : From Theory to Medical and Industrial Applications. |d Burlington : Elsevier Science, �2015 |z 9780444632586 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444632586 |z Texto completo |