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Epigenetics and neuroplasticity - evidence and debate /
The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Waltham, Massachusetts :
Academic Press,
2014.
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| Edición: | First edition. |
| Colección: | Progress in molecular biology and translational science ;
Volume 128. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Epigenetics and Neuroplasticity-Evidence and Debate; Copyright; Contents; Contributors; Preface; Chapter One: The Epigenetic Basis of Memory Formation and Storage; 1. Introduction to the Neurobiology of Learning and Memory; 2. Epigenetic Mechanisms of Memory Consolidation; 2.1. Histone acetylation; 2.2. Histone methylation; 2.3. Histone phosphorylation; 2.4. Histone ubiquitination and sumoylation; 2.5. DNA methylation; 2.6. Summary of epigenetic regulation of memory consolidation; 3. Epigenetic Mechanisms of Memory Reconsolidation.
- 2.2.1. Focus on the HPA axis genes2.2.2. Other stress-responsive genes; 2.3. Genome-wide studies in animals and humans; 3. Epigenetic Mechanisms in Gene by Environment Interactions in PTSD; 4. Conclusions; References; Chapter Three: Histone-Mediated Epigenetics in Addiction; 1. Introduction; 2. General Overview of Histone-Mediated Epigenetics; 3. Learning Processes Involved in the Development of Addiction; 3.1. Initial establishment of drug-associated memories; 3.2. Retrieval of drug-associated memories and extinction of drug-seeking behavior; 4. Histone-Mediated Epigenetic Mechanisms.
- 3.1. Histone modifications during memory reconsolidation3.2. DNA methylation during memory reconsolidation; 3.3. Epigenetic regulation of reconsolidation-dependent memory updating; 3.4. Summary of epigenetic regulation of memory reconsolidation; 4. Epigenetic Mechanisms of Memory Extinction; 5. Future Directions and Conclusions; Acknowledgments; References; Chapter Two: Epigenetics in Posttraumatic Stress Disorder; 1. Introduction; 2. Epigenetic Evidences in PTSD; 2.1. Methodological aspects and tissue specificity; 2.2. Candidate gene approach in animals and humans.
- 4.1. Repressive histone modifications4.1.1. Methylation and phosphorylation; 4.2. Active histone modifications; 4.2.1. Methylation; 4.2.2. Acetylation; 4.2.3. Phosphorylation, ubiquitination, SUMOylation, and poly(ADP-ribosylation); 4.3. Combinatorial modifications; 5. Histone-Mediated Actions in Drug Addiction; 5.1. Methylation and addiction; 5.2. Acetylation and addiction; 5.3. Combinatorial modifications and addiction; 5.4. Summary of histone-mediated epigenetic regulation in addiction; 6. Debates and Considerations.
- 6.1. Are histone marks causal or correlational to downstream processes and do histone modifications change the structure a ... 6.2. What is the relation between memory at the cellular, organismal, and transgenerational levels?; 6.3. What theoretical processes are altered by drugs that target histone modifications during treatment of addiction?; 7. Considerations for Histone-Mediated Treatment of Addiction; Acknowledgments; References; Chapter Four: Modeling the Molecular Epigenetic Profile of Psychosis in Prenatally Stressed Mice; 1. The Epigenetic Hypothesis of Psychosis.