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Epigenetics and neuroplasticity - evidence and debate /
The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Waltham, Massachusetts :
Academic Press,
2014.
|
| Edición: | First edition. |
| Colección: | Progress in molecular biology and translational science ;
Volume 128. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn898999938 | ||
| 003 | OCoLC | ||
| 005 | 20231120111930.0 | ||
| 006 | m o d | ||
| 007 | cr cn||||||||| | ||
| 008 | 141211t20142014mauaf ob 001 0 eng d | ||
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| 020 | |a 9780128010853 |q (e-book) | ||
| 020 | |a 0128010851 |q (e-book) | ||
| 020 | |z 9780128009772 | ||
| 035 | |a (OCoLC)898999938 | ||
| 050 | 4 | |a QH430 |b .E65 2014eb | |
| 082 | 0 | 4 | |a 571.936 |2 23 |
| 245 | 0 | 0 | |a Epigenetics and neuroplasticity - evidence and debate / |c edited by Schahram Akbarian, Farah Lubin. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Waltham, Massachusetts : |b Academic Press, |c 2014. | |
| 264 | 4 | |c �2014 | |
| 300 | |a 1 online resource (263 pages, 12 unnumbered pages of plates) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in Molecular Biology and Translational Science ; |v Volume 128 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ebrary, viewed December 12, 2014). | |
| 505 | 0 | |a Front Cover; Epigenetics and Neuroplasticity-Evidence and Debate; Copyright; Contents; Contributors; Preface; Chapter One: The Epigenetic Basis of Memory Formation and Storage; 1. Introduction to the Neurobiology of Learning and Memory; 2. Epigenetic Mechanisms of Memory Consolidation; 2.1. Histone acetylation; 2.2. Histone methylation; 2.3. Histone phosphorylation; 2.4. Histone ubiquitination and sumoylation; 2.5. DNA methylation; 2.6. Summary of epigenetic regulation of memory consolidation; 3. Epigenetic Mechanisms of Memory Reconsolidation. | |
| 505 | 8 | |a 2.2.1. Focus on the HPA axis genes2.2.2. Other stress-responsive genes; 2.3. Genome-wide studies in animals and humans; 3. Epigenetic Mechanisms in Gene by Environment Interactions in PTSD; 4. Conclusions; References; Chapter Three: Histone-Mediated Epigenetics in Addiction; 1. Introduction; 2. General Overview of Histone-Mediated Epigenetics; 3. Learning Processes Involved in the Development of Addiction; 3.1. Initial establishment of drug-associated memories; 3.2. Retrieval of drug-associated memories and extinction of drug-seeking behavior; 4. Histone-Mediated Epigenetic Mechanisms. | |
| 505 | 8 | |a 3.1. Histone modifications during memory reconsolidation3.2. DNA methylation during memory reconsolidation; 3.3. Epigenetic regulation of reconsolidation-dependent memory updating; 3.4. Summary of epigenetic regulation of memory reconsolidation; 4. Epigenetic Mechanisms of Memory Extinction; 5. Future Directions and Conclusions; Acknowledgments; References; Chapter Two: Epigenetics in Posttraumatic Stress Disorder; 1. Introduction; 2. Epigenetic Evidences in PTSD; 2.1. Methodological aspects and tissue specificity; 2.2. Candidate gene approach in animals and humans. | |
| 505 | 8 | |a 4.1. Repressive histone modifications4.1.1. Methylation and phosphorylation; 4.2. Active histone modifications; 4.2.1. Methylation; 4.2.2. Acetylation; 4.2.3. Phosphorylation, ubiquitination, SUMOylation, and poly(ADP-ribosylation); 4.3. Combinatorial modifications; 5. Histone-Mediated Actions in Drug Addiction; 5.1. Methylation and addiction; 5.2. Acetylation and addiction; 5.3. Combinatorial modifications and addiction; 5.4. Summary of histone-mediated epigenetic regulation in addiction; 6. Debates and Considerations. | |
| 505 | 8 | |a 6.1. Are histone marks causal or correlational to downstream processes and do histone modifications change the structure a ... 6.2. What is the relation between memory at the cellular, organismal, and transgenerational levels?; 6.3. What theoretical processes are altered by drugs that target histone modifications during treatment of addiction?; 7. Considerations for Histone-Mediated Treatment of Addiction; Acknowledgments; References; Chapter Four: Modeling the Molecular Epigenetic Profile of Psychosis in Prenatally Stressed Mice; 1. The Epigenetic Hypothesis of Psychosis. | |
| 520 | |a The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this v. | ||
| 650 | 0 | |a Epigenetics |x History. | |
| 650 | 0 | |a Epigenetics |x Health aspects. | |
| 650 | 6 | |a �Epig�en�etique |0 (CaQQLa)000270630 |x Histoire. |0 (CaQQLa)201-0378888 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Epigenetics |2 fast |0 (OCoLC)fst01893642 | |
| 655 | 7 | |a History |2 fast |0 (OCoLC)fst01411628 | |
| 700 | 1 | |a Akbarian, Schahram, |e editor. | |
| 700 | 1 | |a Lubin, Farah, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Epigenetics and neuroplasticity - evidence and debate. |b First edition. |d Waltham, Massachusetts : Academic Press, �2014 |h xiii, 236 pages |k Progress in molecular biology and translational science ; Volume 128 |z 9780128009772 |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v Volume 128. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128009772 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/128 |z Texto completo |