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Sertoli cell biology /
Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm p...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
2015.
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| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Sertoli Cell Biology; Copyright Page; Contents; List of contributors; Preface; 1 Sertoli cell anatomy and cytoskeleton; I Introduction; II Sertoli cell morphology; A The nucleus; B Cytoplasm and membrane interactions; III Sertoli cell cytoskeleton; A Actin filaments; 1 Ectoplasmic specializations; 2 Tubulobulbar complexes; B Microtubules; C Intermediate filaments; 1 Desmosome-like junctions and intermediate filaments; 2 Hemidesmosome-like junctions and intermediate filaments; D Regulation of the cytoskeleton; IV Concluding remarks; References.
- 2 Establishment of fetal Sertoli cells and their role in testis morphogenesisI Introduction; A Highlights/milestones since last volume; II Establishment of the gonadal primordium; III Sertoli cell specification and diversion of molecular development toward the testis pathway; IV Organizational functions of fetal Sertoli cells; A Formation of testis cords and establishment of testis-specific vasculature; B Coordinate development of the interstitium and its resident cell types; C Regression of female reproductive tracts by Amh; D Regulation of fetal germ cell development by Sertoli cells.
- E Regulation of testis cord elongationSummary; References; 3 Early postnatal interactions between Sertoli and germ cells; I Introduction; II Neonatal testis development; A Gonocyte development; B Sertoli cell development; III Role of Sertoli cells in gonocyte proliferation and migration; A Regulation of gonocyte proliferation; B Control of gonocyte migration; IV Role of Sertoli cells in formation of primary undifferentiated and differentiating spermatogonial populations; A Transition of gonocyte to stem and progenitor spermatogonia; B Transition of gonocytes to differentiating spermatogonia.
- V Concluding remarksReferences; 4 The spermatogonial stem cell niche in mammals; I Research advances related to the mammalian SSC niche since 2003; II Principles of stem cell niches in mammalian tissues; III Spermatogonial stem cells; IV Location of the SSC; V Factors governing SSC self-renewal and differentiation; VI The environment inside and outside the niche; VII The role of cell migration in SSC self-renewal and differentiation; VIII Spermatogonial differentiation; IX Niche localization: what controls the controller?; X The SSC niche and the cycle of the seminiferous epithelium.
- XI The SSC niche during cell lossXII Perspectives; Acknowledgments; References; 5 DMRT1 and the road to masculinity; I Introduction; Doublesex (dsx) and male abnormal-3 (mab-3) related transcription factor and the DM domain; II DMRT1 expression; III Regulation of DMRT1; A Endocrine; B Temperature; IV DMRT1 locus and gene expression; A DMRT1 locus; B In silico sequence analysis; C DMRT1 5'-flanking region; D Distal ECRs; E Transcriptional activity; F Transient transfection analysis; G Transgenic analysis; H Posttranscriptional regulation; V DMRT1 function.