Bursting neurons and fading memories : an alternative hypothesis of the pathogenesis of Alzheimer's disease /

Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighbor...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: D'Andrea, Michael R. (Michael Robert) (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Elsevier, [2015]
Temas:
Alzheimer's disease > Pathogenesis.
Alzheimer Disease > etiology
Maladie d'Alzheimer > Pathogen�ese.
Alzheimer's disease > Pathogenesis
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover; Title Page; Copyright Page; Dedication; Table of contents; About the Author; Preface; Acknowledgments; Introduction; References; Chapter 1
  • Alzheimer's Disease Today; Neurological factors; Non-neurological factors; The amyloid cascade; Looking ahead; References; Chapter 2
  • Seeds of a New Perspective; Histology; Ready to start; References; Chapter 3
  • Introducing the "Inside-Out" Hypothesis; Presentation time; References; Chapter 4
  • Addressing Technical Concerns; Lipofuscin; Primary antibodies; Heat is the ticket; Antibodies; In situ ELISA; References
  • Chapter 5
  • The Good Intentions of Formic AcidFormic acid is the problem; Running like mascara; Reference; Chapter 6
  • Connecting MAP-2 and Cell Lysis; Reverse logic; Diffuse plaques are benign; Troublesome end point; Reference; Chapter 7
  • Classifying Plaques; Three dimensions; Multiple colors; Inflammation; Triple IHC; Microglia's unanticipated location; The diffuse amyloid plaque; Diffuse-vascular amyloid plaques; Dense-vascular amyloid plaques and others; Call for a nomenclature; References; Chapter 8
  • When Is a Star Like a Plaque?; Similar initial hypotheses; New technology
  • Reflections of a discoveryReinforcing evidence; Star nomenclature; Scientific parallels; Composition; Closing comment; References; Chapter 9
  • The Inflammation Cascade; References; Chapter 10
  • Innocent Ab42; References; Chapter 11
  • The Alpha 7 Nicotinic Acetylcholine Receptor; References; Chapter 12
  • Immunoglobulin: Another Perpetrator; Immunoglobulin neurons; Degenerating Ig-positive neurons; References; Chapter 13
  • Add AD to the List of Autoimmune Diseases; References; Chapter 14
  • The BBB and BRB in AD; BRB, a vascular harbinger; In vivo BBB support; References
  • Chapter 15
  • "Inside-Out" in the FieldNeuronal death by amyloid (via vascular issues); Neuronal death by ApoE4; Neuronal death by inflammation; Neuronal death by tau; Neuronal death by autoantibodies; Miscellaneous notes; References; Chapter 16
  • Alzheimer's Disease Tomorrow; State of the AD nation; Targeting the a7 receptor; Targeting Ab42: not plaques; Targeting the BBB; Targeting inflammation; Biomarker discovery; Assessing BBB integrity via BRB; New work; Closing statement; References; Glossary

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