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Neuroimmune Signaling in Drug Actions and Addictions /
This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on Neuroimmune Signaling in Drug Actions and Addictions.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK ; San Diego, CA :
Academic Press,
2014.
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| Edición: | First edition. |
| Colección: | International review of neurobiology ;
v. 118. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Neuroimmune Signaling in Drug Actions and Addictions; Copyright; Contents; Contributors; Chapter One: Neuroimmune Mechanisms of Alcohol and Drug Addiction; 1. Introduction; 2. Neuroimmune Modulation of Synaptic Function; 3. Neuroinflammation; 4. Neuroimmune Molecules in Neurodevelopment; 5. Neuroimmune Factors Modulate Neuroendocrine Function; 6. Neuroimmune Mechanism and Addiction; 7. Summary; References; Chapter Two: Neuroimmune Pathways in Alcohol Consumption: Evidence from Behavioral and Genetic Studies in Rodents and Humans; 1. Introduction.
- 2. Immune Regulation of Ethanol Consumption and Ethanol Regulation of Immune Signaling3. Peroxisome Proliferator-Activated Receptors: Anti-Inflammatory Action and Role in Alcohol Consumption; 4. Alcohol Consumption and Neuroimmune-Related Gene Expression; 5. Alcohol Consumption and Neuroimmune-Related microRNAs; 6. Conclusions; Acknowledgments; References; Chapter Three: Fetal Alcohol Spectrum Disorders and Neuroimmune Changes; 1. Overview of Fetal Alcohol Spectrum Disorders; 2. Normal Brain Development; 3. FASD Neuropathology in Humans; 4. FASD Neuropathology in Animal Models.
- 5. Behavioral Consequences in Humans with FASD6. Behavioral Consequences in Rodent Models of FASD; 7. Overview: Alcohol Effects on Immune Response in the Brain; 8. Microglia; 8.1. Overview; 8.2. Role in the CNS development; 8.3. Function in the healthy CNS; 8.4. Immune response; 9. Potential Long-Term Consequences of Immune Activation in the Developing CNS; 10. Link Between Ethanol and Immune Responses; 10.1. Human studies; 10.2. Animal studies; 10.3. Signaling pathways; 11. Therapies; 11.1. Early diagnosis of FASD; 11.2. Development of novel anti-inflammatory therapies for FASD.
- 11.2.1. Pioglitazone11.2.2. Minocycline; 11.2.3. Naltrexone; 12. Conclusions; Acknowledgments; References; Chapter Four: Role of Microglia in Regulation of Ethanol Neurotoxic Action; 1. Introduction; 2. Microglial Cell Functions in the CNS; 2.1. Microglial response to pathogens and tissue damage; 2.2. Microglia, inflammation, and cell death; 2.3. Microglial modulation of neuronal activity and development; 3. Microglial Mechanisms of the Neurotoxic Effects of Alcohol; 3.1. Alcohol-induced microglial activation, inflammation, and neurotoxicity.
- 3.2. Alcohol-induced microglial production of ROS and neurotoxicity4. Protective Effects of Microglia; 5. Alcohol-Related Disease, Neurotoxicity, and Microglia; 5.1. Adult alcohol-use disorders; 5.2. Fetal alcohol spectrum disorders; 5.3. Microglia priming hypothesis; 6. Summary and Future Directions; Acknowledgments; References; Chapter Five: Functions of the Chemokine Receptor CXCR4 in the Central Nervous System and Its Regulation by o-Opioid Rece ... ; 1. Chemokine System Overview; 2. Opioid System Overview; 3. CXCR4 and Opioids Actions in the Central Nervous System.