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141029s1982 nyua ob 101 0 eng d |
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|a 907143695
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|a Comprehensive Sickle Cell Center Symposium on the Molecular Basis of Mutant Hemoglobin Dysfunction
|d (1979 :
|c University of Chicago)
|
| 245 |
1 |
4 |
|a The molecular basis of mutant hemoglobin dysfunction /
|c editor: Paul B. Sigler.
|
| 264 |
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1 |
|a New York :
|b Elsevier/North-Holland,
|c [1982]
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| 264 |
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4 |
|c �1982
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| 300 |
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|a 1 online resource (xii, 338 pages) :
|b illustrations
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a The University of Chicago Sickle Cell Center hemoglobin symposia ;
|v volume 1
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| 500 |
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|a "Proceedings of the Comprehensive Sickle Cell Center Symposium on the Molecular Basis of Mutant Hemoglobin Dysfunction at the University of Chicago ... October 7-10, 1979--Verso of title page
|
| 504 |
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|a Includes bibliographical references and index.
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| 588 |
0 |
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|a Print version record.
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| 505 |
0 |
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|a Front Cover; The Molecular Basic of Mutant Hemoglobin Dysfunction; Copyright Page; Table of Contents; Dedication; Preface; Chapter 1. Plenary Address: Molecular Disease; Sickle Cell Anemia-An Amino Acid Substitution; Alleles; Protein Conformation at the Sickle Cell Mutation; Red Cell Membrane in Sickle Cell Anemia; Sickle Cell Anemia and Population Genetics: Balanced Polymorphisms; Hemoglobin C; The Genetic Code; Types of Mutations in the Abnormal Hemoglobins; Switch Back to Fetal Hemoglobin; Unequal Crossing-Over: Hemoglobin Lepore; Globin Gene Structure.
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| 505 |
8 |
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|a Molecular Biology and the Treatmentof the HemoglobinopathiesReferences; SECTION I: Some Clinical Problems Stated for the Molecular Biologist; Chapter 2. The Influence of Fetal Hemoglobin on the Risk of Complications of Sickle Cell Anemia; Introduction; Materials and Methods; Results; Discussion; References; Chapter 3. Ocular Manifestations of Sickle Cell Disease; Conjunctival Findings; Retinal Changes in Sickle Disease; Vascular Tortuosity; Macular Remodeling; Proliferative Sickle Retinopathy (PSR) Peripheral Retinal Remodeling ; Arteriolar-Venular Anastomosis (Stage II) (see Table 1).
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| 505 |
8 |
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|a Proliferative Sickle Retinopathy (PSR) (Stage III) (see Table 2)Vitreous Hemorrhage (Stage IV); Pathogenesis; Summary; References; SECTION II: Expression of Normal and Abnormal Genes; Chapter 4. Introductory Remarks: Human Globin Gene Expression; References; Chapter 5. Organization of Normal and Abnormal Human Globin Genes by Restriction Enzyme Analysis; Experimental Procedures; Results; Prenatal Diagnosis of the a Thalassemias; The Prenatal Diagnosis of Sickle Cell Anemia; Acknowledgments; References.
|
| 505 |
8 |
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|a Chapter 6. The a-Globin Genotype as a Determinant of Hematologie Parameters in Sickle Cell Trait1Introduction; Methods; Results; Discussion; References; Chapter 7. Characterization of Linked Human Globin Genes by Molecular Cloning Procedures; Acknowledgments; References; Chapter 8. Regulation of Human Globin Gene Expression after Gene Transfer; Gene Transfer by Somatic Cell Hybridization; Possible Regulatory Mechanisms for Globin Gene Expression; Possible Post-transcriptional Control of Globin Synthesis; Gene Transfer by Physical Microinjection; References.
|
| 505 |
8 |
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|a Chapter 9. The Introduction of Normal and Mutant Globin Genes into Mammalian Cells Using SV40 VectorsIntroduction; Expression of a Complete Globin Gene; A Deleted Giobin Gene; Possibility of Studying Thalassemic Genes; Acknowledgments; References; SECTION III: Structure Analysis of Mutant Hemoglobins and Their Aggregates; Chapter 10. Introductory Remarks: Structural Analysis of Mutant Hemoglobins and Their Aggregates; References; Chapter 11. Flexibility of the NH2-Terminal Region of the � Chains of Hemoglobin: Correlation with the Gelation Properties of Deoxyhemoglobin S; Introduction.
|
| 650 |
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0 |
|a Sickle cell anemia
|x Genetic aspects
|v Congresses.
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| 650 |
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0 |
|a Hemoglobinopathy
|x Genetic aspects
|v Congresses.
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| 650 |
|
0 |
|a Pathology, Molecular
|v Congresses.
|
| 650 |
|
6 |
|a Dr�epanocytose
|0 (CaQQLa)201-0000897
|x Aspect g�en�etique
|0 (CaQQLa)201-0377534
|v Congr�es.
|0 (CaQQLa)201-0378219
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| 650 |
|
6 |
|a Pathologie mol�eculaire
|0 (CaQQLa)201-0062220
|v Congr�es.
|0 (CaQQLa)201-0378219
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| 650 |
|
7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
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| 650 |
|
7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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| 650 |
|
7 |
|a Hemoglobinopathy
|x Genetic aspects
|2 fast
|0 (OCoLC)fst00955066
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| 650 |
|
7 |
|a Pathology, Molecular
|2 fast
|0 (OCoLC)fst01054980
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| 650 |
|
7 |
|a Sickle cell anemia
|x Genetic aspects
|2 fast
|0 (OCoLC)fst01118097
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| 655 |
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2 |
|a Congress
|0 (DNLM)D016423
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| 655 |
|
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|a proceedings (reports)
|2 aat
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| 655 |
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|a Conference papers and proceedings
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| 655 |
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7 |
|a Conference papers and proceedings.
|2 lcgft
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| 655 |
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7 |
|a Actes de congr�es.
|2 rvmgf
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|
| 700 |
1 |
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|a Sigler, Paul B.,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Comprehensive Sickle Cell Center Symposium on the Molecular Basis of Mutant Hemoglobin Dysfunction (1979 : University of Chicago).
|t Molecular basis of mutant hemoglobin dysfunction
|z 0444006311
|w (DLC) 82121383
|w (OCoLC)8953924
|
| 830 |
|
0 |
|a University of Chicago Sickle Cell Center hemoglobin symposia ;
|v volume 1.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780444006318
|z Texto completo
|
