Medicinal chemistry-III : main lectures presented at the third International Symposium on Medicinal Chemistry held in Milan, Italy, 13-15 September 1972 /

Medicinal Chemistry-III provides information pertinent to the fundamental aspects of medicinal chemistry. This book discusses the mechanism of action of drugs at the molecular level. Organized into eight chapters, this book begins with an overview of the systems for protein biosynthesis that are cla...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores Corporativos: International Symposium on Medicinal Chemistry Milan, Italy, International Union of Pure and Applied Chemistry. Organic Chemistry Division
Otros Autores: Pratesi, P. (Editor )
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: London : Butterworths, 1973.
Temas:
Pharmaceutical chemistry > Congresses.
Pharmaceutical chemistry.
Chemistry, Pharmaceutical
Chimie pharmaceutique > Congr�es.
Chimie pharmaceutique.
MEDICAL > Pharmacology.
Pharmaceutical chemistry
Congress
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congr�es.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Medicinal Chemistry-III; Copyright page; Table of Contents; OPENING REMARKS; CHAPTER 1. THE MECHANISMS OF SELECTIVITY AND ACTIONOF PROTEIN SYNTHESIS INHIBITORS; ABSTRACT; THE MECHANISM OF PROTEIN SYNTHESIS; SELECTIVITY OF PROTEIN SYNTHESIS INHIBITORS; RIBOSOME SUBUNITS AS SPECIFIC TARGETS OF ANTIBIOTIC ACTION; INHIBITORS OF THE INITIATION PHASE; INHIBITORS OF THE ELONGATION CYCLE; REFERENCES; CHAPTER 2. THE SIGNIFICANCE OF D-ALANYL-D-ALANINE TERMINI IN THE BIOSYNTHESIS OF BACTERIAL CELL WALLS AND THE ACTION OF PENICILLIN, VANCOMYCIN AND RISTOCETIN; ABSTRACT; INTRODUCTION.
  • PENICILLINVANCOMYCIN AND RISTOCETIN; COMPETITION FOR VANCOMYCIN BINDING SITES; CONCLUSION; REFERENCES; CHAPTER 3. INHIBITORS OF THE TRANSCRIBING ENZYMES; ABSTRACT; INTRODUCTION; TRANSCRIPTASE (DNA-DEPENDENT RNA POLYMERASE): STRUCTURE AND FUNCTION; SPECIFIC INHIBITORS OF TRANSCRIPTASE; STRUCTURAL MODIFICATIONS OF THE RIFAMYCINS ANDTHEIR EFFECT ON ANTIBACTERIAL ACTIVITY; ACTIVITY OF RIFAMYCINS ON VIRAL TRANSCRIPTASES; ACKNOWLEDGMENT; REFERENCES; CHAPTER 4. ANALOGUES OF CYCLIC AMP AND THEIRPHYSIOLOGICAL RESPONSE; ABSTRACT; THE SECOND MESSENGER MODEL; THE cAMP-SYSTEM; cAMP-ANALOGUES.
  • GLYCOGENOLYSISSTEROIDOGENESIS; LIPOLYSIS; SECRETION OF PITUITARY HORMONES; EFFECTS OF cAMP-ANALOGUES ON CONTRACTILE TISSUES; PHARMACOLOGICAL ASPECTS; REFERENCES; CHAPTER 5. PRINCIPLES OF NEUROCHEMISTRY AND DRUG SCREENING PROCEDURES INNEUROPSYCHOPHARMACOLOGY; ABSTRACT; INTRODUCTION; THE CONCEPT OF POSTSYNAPTIC RECEPTOR IN DRUG DEVELOPMENT; REFERENCES; CHAPTER 6. ACTIVE POLYPEPTIDES OF THE AMPHIBIAN SKINAND THEIR SYNTHETIC ANALOGUES; ABSTRACT; INTRODUCTION; PHYSALAEMIN-LIKE PEPTIDES; BRADYKININ-LIKE PEPTIDES; CAERULEIN-LIKE PEPTIDES; BOMBESIN-LIKE PEPTIDES; MISCELLANEOUS POLYPEPTIDES.
  • Discussionacknowledgements; references; chapter 7. some biological applications of regularsolution theory; abstract; introduction; historical foundations; models for the analysis of biological activities; formulation in terms of regular solution theory; application to studies of erythrocyte haemolysis; conclusions; references; chapter 8. the prediction of molecular conformation as a biologicallysignificant property; abstract; introduction; evaluation of conformation; molecular orbital prediction of conformation; muscarinic agents; nicotinic agents; histamine; serotonin; pregnane steroids.
  • Adrenergic agentsdopamine; central inhibitory transmitters; prostaglandin; peptide hormones; sweet taste pharmacophore; conclusion; references; concluding remarks.

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