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Molecular genetic medicine. Volume 3 /
Molecular Genetic Medicine, Volume III, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The book opens with a chapter on the birth and early development of the field of human gene therapy and the earliest conceptual and technical descriptions of...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
[1993]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Molecular Genetic Medicine; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1. Milestones and Events in the Early Development of Human Gene Therapy; I. Phase 1. Prior to 1970: Genetically Marked Cells and DNA-Mediated Transformation; II. Phase 2. The Cline Experiment, Efficient Vectors, in Vitro Models, and the Maturing Ethical and Public Policy Debate; III. Phase 3. The Regulatory Process and the First Direct Clinical Applications: The Recombinant Advisory Committee (RAC), Its Gene Therapy Subcommittee, and the Food and Drug Administration (FDA); Acknowledgment.
- IX. A Clonal Evolution Model for Astrocytic TumorsX. Testing the Genetic Model; XI. Conclusion; References; Chapter 4. Molecular Biology of Alzheimer's Disease; I. Introduction; II. History; III. Epidemiology; IV. Genetics; V. Clinical and Neuropsychological Features; VI. Diagnosis; VII. Treatment; VIII. Nerve Growth Factor and Related Molecules in the Central Nervous System; IX. Central Actions of Nerve Growth Factor; X. NGF-Related Trophic Factors: The Neurotrophins; XI. Neurotrophin Receptors; XII. NGF Mechanism of Action; XIII. A Model of Trophic Factor Action in Neurodegenerative Disease.
- XIV. Molecular NeuropathologyXV. Amyloid Deposition in Alzheimer's Disease; XVI. �APP Processing; XVII. Conclusion: Clinical and Societal Implications; References; Chapter 5. Hunting for Huntington's Disease; I. Introduction; II. Finding a Landmark near HD; III. Which Way to the Prey?; IV. Physical Layout of the Search Area; V. Tools for Tracking; VI. Limiting the Hunt Using Crossovers in Disease Pedigrees; VII. The Historical Trail of HD in Allele Associations; VIII. What Is the Nature of the Quarry?; Acknowledgments; References; Note Added in Proof: Hunting's Done!
- Chapter 6. Genetics, Insurance, and the Ethics of Genetic CounselingI. Introduction: Genetic Prediction and the Challenge to Insurance; II. Health Insurance; III. Life Insurance; IV. Ethical Conflicts of Providers of Genetic Services; V. Conclusion; References; Index.