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Primary immunodeficiency disorders : a historic and scientific perspective /
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can m...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford, England ; Waltham, Massachusetts :
Academic Press,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright Page; Contents; Contributors; Foreword; The Giants of Our Field; The right time; The right place; Introduction; Chapter 1
- Immunity: From Serendipitous Observations to Science-Based Specialty; Serendipitous Observations; A Cell Derives From a Cell, a Microorganism from a Microbe; Serum therapy, active Immunization and the concept of antibodies; Epicrisis; References; Chapter 2
- Discovery of the T- and B-Cell Compartments; Introduction; Discovery of the importance of the thymus in immune system development; En route to Bob Good's research group in Minnesota.
- The atmosphere in Bob Good's laboratoryConnecting Studies in Chicks and Immunodeficiency Diseases; The key experiments in irradiated birds; The initial T- and B-cell model and its clinical implications; Basic questions posed by the separate T- and B-lineage model; The long search for the mammalian bursa-equivalent; The identification of B-lineage progenitors; An ancient blueprint for the T- and B-cell lineages; Acknowledgments; References; Chapter 3
- Evolution of the Definition of Primary Immunodeficiencies; Introduction.
- The birth of classical PIDs, illustrated by the discovery of X-linked agammaglobulinemiaThe concept of PIDs with narrow phenotype, illustrated by X-linked lymphoproliferative disease; The development of PIDs with narrow phenotype, illustrated by Mendelian susceptibility to mycobacterial disease; PIDs with narrow phenotypes underlying common infections, illustrated by herpes simplex virus encephalitis of childhood; Conclusions and perspectives; Acknowledgments; References; Chapter 4
- From Immunodeficiency to Autoimmunity.
- A Historical Journey into Recognition of Immunodeficiency and AutoimmunityAutoimmunity: An Often Neglected Feature of Immune Deficiency; Omenn Syndrome: Inflammation and Autoimmunity in Immune Deficiency; Expanding the Spectrum of Autoimmunity in RAG Deficiency; The Lesson Learned: When Combined Immunodeficiency and Autoimmunity go Hand-In-Hand; References; Chapter 5
- Immunological Tests
- from the Microscope to Whole Genome Analysis; Introduction; History of the Evaluation of Humoral Immunity; History of the Evaluation of Cellular (T-cell) Immunity.
- History of the Evaluation of the IL12/23-interferon-g circuitHistory of the Evaluation of NK-cell defects; History of the Evaluation of Toll-like receptor defects; History of the Evaluation of Neutrophil Immunity; History of the Evaluation of the Complement System; Conclusion; Acknowledgment; References; Chapter 6
- Primary Immunodeficiency in the Developing Countries; Introduction; History of Primary Immunodeficiency in Africa; Early Initiatives by Individual Visionaries; Establishment of Centers Specializing in PID; Efforts to Organize: The Foundation of ASID; PID Management in Africa.