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Movement disorders : genetics and models /

The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource fo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: LeDoux, Mark (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Elsevier/Academic Press, [2015]
Edición:Second edition.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Section I: Scientific foundations. Taxonomy and clinical features of movement disorders
  • Modeling disorders of movement
  • New transgenic technologies
  • Assessment of movement disorders in rodents
  • Drosophila
  • Use of Caenorhabditis elegans to model human movement disorders
  • Zebrafish
  • Techniques for motor assessment in rodents
  • Induced pluripotent stem cells (iPSCs) to study and treat movement disorders
  • Neurophysiologic assessment of movement disorders in humans
  • Neurophysiological and optogenetic assessment of brain networks involved in motor control
  • Functional imaging to study movement disorders
  • Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders
  • Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease
  • genetics and molecular biology of Parkinson disease
  • Genotype-phenotype correlations in Parkinson Disease
  • From man to mouse: the MPTP model of Parkinson disease
  • Rodent models of autosomal dominant Parkinson disease
  • Rodent models of autosomal recessive Parkinson disease
  • Drosophila models of Parkinson Disease
  • Primate models of complications related to Parkinson disease treatment
  • Rodent models of treatment-related complications in Parkinson disease
  • Methods and models of the nonmotor symptoms of Parkinson disease
  • Section III: Dystonia. Dystonia: phenotypes and genetics
  • Murine models of caytaxin deficiency
  • Animal models of focal dystonia
  • Mouse models of dystonia
  • Rodent models of autosomal dominant primary dystonia
  • Modeling dystonia-parkinsonism
  • Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders
  • Murine models of HD
  • Use of genetically engineered mice to study the biology of huntingtin
  • Modeling Huntington disease in yeast and invertebrates
  • HDL2 mouse
  • Analysis of nonmotor features in murine models of Huntington Disease
  • Section V: Tremor. Essential tremor
  • Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor
  • Physiological and behavioral assessment of tremor in rodents
  • Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation
  • Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics
  • Mouse model of Unverricht-Lundborg disease
  • Post-hypoxic myoclonus in rodents
  • Generating mouse models of mitochondrial disease
  • Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology
  • Genetics of Tourette syndrome
  • Neural circuit abnormalities in Tourette syndrome
  • Animal models of Tourette Syndrome and obsessive-compulsive disorder
  • Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features
  • Mouse models of PNKD
  • Glut1 deficiency (G1D)
  • Animal models of episodic ataxia type 1 (EA1)
  • Mouse models of episodic ataxia type 2.
  • Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics
  • Drosophila models of tauopathy
  • Tauopathy mouse models
  • Tau protein: biology and pathobiology
  • Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity
  • Animal models of multiple-system atrophy
  • Modeling PKAN in mice and flies
  • Mouse models of FA2H deficiency
  • Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations
  • Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias
  • Animal models of spinocerebellar ataxia type 1
  • Mouse models of SCA3 and other polyglutamine repeat ataxias
  • animal models of Friedreich ataxia
  • Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM)
  • Autosomal recessive ataxias due to defects in DNA repair
  • Caenorhabditis elegans models to study the molecular biology of ataxias
  • Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features
  • Mouse models of autosomal dominant spastic paraplegia
  • Murine models of autosomal recessive hereditary spastic paraplegia
  • Modeling hereditary spastic paraplegia (HSP) in zebrafish
  • Drosophila models of hereditary spastic paraplegia
  • Caenorhabditis elegans models of hereditary spastic paraplegia
  • Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders
  • Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome
  • Combined D3 receptor/iron-deficient mouse model
  • Use of Drosophila to study restless legs syndrome
  • The A11 lesion/iron deprivation animal model of restless legs syndrome
  • Btbd9 knockout mice as a model of restless legs syndrome.