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Molecular targets in protein misfolding and neurodegenerative disease /
Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, d...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2015.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Seneci, Pierfausto, |e author. | |
| 245 | 1 | 0 | |a Molecular targets in protein misfolding and neurodegenerative disease / |c Pierfausto Seneci. |
| 264 | 1 | |a London : |b Academic Press, |c 2015. | |
| 264 | 4 | |c �2015 | |
| 300 | |a 1 online resource (314 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc | ||
| 505 | 0 | |a Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 -- Protein Misfolding, Neurodegeneration and Tau; 1.1 -- The neurodegeneration scenario; 1.2 -- Protein folding: physiological benefits and pathological consequences; 1.3 -- Tau: An intrinsically disordered, flexible, and aggregation-prone protein; 1.4 -- Tauopathies: Aggregation-prone tau in neurodegenerative disease (NDD); 1.4.1 -- Class 0 Tauopathies; 1.4.2 -- Class I Tauopathies; 1.4.3 -- Class II Tauopathies; 1.4.4 -- Class III Tauopathies; 1.4.5 -- Class IV Tauopathies; 1.4.6 -- Tau Mutations; References. | |
| 505 | 8 | |a Chapter 2 -- Targeting the Protein Quality Control (PQC) Machinery2.1 -- Molecular chaperones, PQC, and neurodegeneration; 2.2 -- Molecular targets; 2.2.1 -- Hsp27; 2.2.2 -- Hsp70; 2.2.3 -- Hsp90; 2.3 -- Disease-modifying compounds; References; Chapter 3 -- Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 -- UPS-mediated degradation of misfolded proteins; 3.2 -- UPS-mediated degradation of misfolded proteins in NDDs; 3.3 -- UPS-targets; 3.3.1 -- CHIP; 3.3.2 -- USP14; 3.4 -- Disease-modifying compounds; References; Chapter 4 -- Unselective Disposal of Cellular Aggregates. | |
| 505 | 8 | |a 4.1 -- Autophagy-mediated degradation of protein aggregates4.2 -- Autophagy-mediated degradation of protein aggregates in NDDs; 4.3 -- Macroautophagy-targets; 4.3.1 -- mTORC1; 4.4 -- Disease-modifying compounds; References; Chapter 5 -- Selective Disposal of Insoluble Protein Aggregates; 5.1 -- Aggrephagy-mediated degradation of protein aggregates; 5.2 -- Selective autophagy-mediated degradation of protein aggregates in NDDs; 5.3 -- Selective autophagy-targets; 5.3.1 -- p62; 5.3.2 -- HDAC6; 5.4 -- Disease-modifying compounds; References; Chapter 6 -- Assembly and Disassembly of Protein Aggregates. | |
| 505 | 8 | |a 6.1 -- Introduction6.2 -- Disordered protein aggregates and ordered amyloid fibrils; 6.2.1 -- The Target: Interfering with (Neuro)toxic Tau Species in the Aggregation Process; 6.3 -- Chaperone-driven disaggregation of protein aggregates; 6.3.1 -- The Target: Hsp110; 6.4 -- Disease-modifying compounds; References; Conclusions; Index. | |
| 650 | 0 | |a Molecular neurobiology. | |
| 650 | 0 | |a Nervous system |x Diseases. | |
| 650 | 1 | 2 | |a Tauopathies |x drug therapy |0 (DNLM)D024801Q000188 |
| 650 | 1 | 2 | |a Tauopathies |x etiology |0 (DNLM)D024801Q000209 |
| 650 | 2 | |a Nervous System Diseases |0 (DNLM)D009422 | |
| 650 | 2 | 2 | |a Molecular Targeted Therapy |x methods |0 (DNLM)D058990Q000379 |
| 650 | 2 | 2 | |a Protein Folding |x drug effects |0 (DNLM)D017510Q000187 |
| 650 | 6 | |a Neurobiologie mol�eculaire. |0 (CaQQLa)201-0167529 | |
| 650 | 6 | |a Syst�eme nerveux |x Maladies. |0 (CaQQLa)201-0007359 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Zoology |x General. |2 bisacsh | |
| 650 | 7 | |a Molecular neurobiology |2 fast |0 (OCoLC)fst01024815 | |
| 650 | 7 | |a Nervous system |x Diseases |2 fast |0 (OCoLC)fst01036098 | |
| 776 | 0 | 8 | |i Print version: |a Seneci, Pierfausto. |t Molecular targets in protein misfolding and neurodegenerative disease. |d London : Academic Press, �2015 |h xvii, 295 pages |z 9780128001868 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128001868 |z Texto completo |