Advances in cancer research. emerging applications of molecular imaging to oncology / Volume 124 :

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, inclu...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Pomper, Martin (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London [England] ; San Diego, California : Academic Press, 2014.
Temas:
Cancer > Imaging.
Cancer > Diagnosis > Equipment and supplies.
Cancer > Molecular aspects.
Cancer > Imagerie.
Cancer > Diagnostic > Appareils et mat�eriel.
Cancer > Aspect mol�eculaire.
Cancer > Diagnosis > Equipment and supplies
Cancer > Imaging
Cancer > Molecular aspects
Acceso en línea:Texto completo
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Tabla de Contenidos:
  • Front Cover; Emerging Applications of Molecular Imaging to Oncology; Copyright; Contents; Contributors; Preface; Chapter One: Quantitative Radiology: Applications to Oncology; 1. Introduction; 2. Radiological Characterization of Tumors; 2.1. Computed tomography; 2.1.1. Structural (routine) CT; 2.1.2. CT perfusion; 2.1.3. Dual-energy CT; 2.2. Magnetic resonance; 2.2.1. Structural (routine) MR; 2.2.2. MR spectroscopy and hyperpolarization; 2.2.3. MR perfusion; 2.2.4. Diffusion-weighted imaging; 2.2.5. Diffusion tensor imaging; 2.3. Positron emission tomography; 3. Quantitative Radiology
  • 3.1. Image analysis3.1.1. Manual segmentation; 3.1.2. Automated segmentation; 3.1.3. Registration; 3.2. Evaluation; 3.3. Integration; 4. Future Directions; 5. Conclusion; References; Chapter Two: The Intricate Role of CXCR4 in Cancer; 1. Introduction; 2. CXCR4/CXCL12 Signaling; 3. Expression and Physiological Functions of the CXCR4/CXCL12 Axis; 4. Role of CXCR4 in Cancer; 4.1. Leukemia; 4.2. Multiple myeloma; 4.3. Breast cancer; 4.4. Prostate cancer; 4.5. Ovarian cancer; 4.6. Lung cancer; 4.7. Gastrointestinal cancers; 4.8. Renal cell carcinoma; 4.9. Melanoma; 4.10. Brain tumors
  • 4.11. Soft tissue sarcomas5. CXCR4 Antagonists as Therapeutic and Imaging Agents; 6. Peptides and Peptidomimetics; 6.1. CXCL12-based peptides; 6.2. Synthetic peptide CXCR4 antagonists; 6.3. Small cyclic peptide analogues; 6.4. Antibodies against CXCR4; 6.5. LMW CXCR4 antagonists; 7. Conclusion; Acknowledgments; References; Chapter Three: Recent Advances in Nanoparticle-Based Nuclear Imaging of Cancers; 1. Introduction; 2. Lipid-Based Nanoparticles; 3. Dendrimers; 4. Polymers; 5. Quantum Dots; 6. Iron Oxide Nanoparticles; 7. Gold Nanoparticles; 8. Carbon Nanotubes
  • 9. Silica-Based Nanoparticles10. Conclusion; References; Chapter Four: Molecular-Genetic Imaging of Cancer; 1. Introduction; 2. Promoters; 3. Reporters; 4. Signal Enhancement of Reporters; 4.1. Enhancers; 4.2. Two-step transcriptional amplification; 4.2.1. Bidirectional TSTA; 4.2.2. Lentivirus-TSTA; 4.2.3. Adeno-TSTA; 4.2.4. Advanced TSTA system; 4.2.5. Replacing components of the TSTA; 4.2.6. Titratable TSTA; 4.2.7. Dual TSTA; 4.2.8. TSTA for imaging cellular differentiation; 4.3. Codon optimization; 4.4. Posttranscriptional regulatory elements; 4.5. Synthetic super promoter
  • 4.6. Introducing introns5. Prolonged Expression of Reporters; 6. Machinery for Gene Delivery; 6.1. Cationic polymers (polyplexes); 6.2. Positively charged lipids (lipoplexes); 6.3. Nanoparticles (nanoplexes); 7. Size and Immunogenicity; 8. Concluding Remarks; Acknowledgments; References; Chapter Five: Real-Time Fluorescence Image-Guided Oncologic Surgery; 1. Introduction; 1.1. Need for real-time image-guided surgery; 1.2. Current methods available for image-guided surgery; 1.3. Optical methods amenable to image-guided surgery; 2. Fluorescence Imaging Systems for Intraoperative Procedures

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