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Brain transcriptome /
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely r...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London [England] ; San Diego, California :
Elsevier,
2014.
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| Colección: | International review of neurobiology ;
Volume one hundred and sixteen. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Cover image; Title page; Table of Contents; Copyright; Contributors; Chapter One: Introduction to Sequencing the Brain Transcriptome; Abstract; 1 Introduction; 2 From Microarrays to RNA-Seq; 3 NGS Platforms; 4 RNA-Seq Overview; 5 RNA-Seq and Data Analysis; 6 Sequencing the Brain Transcriptome; 7 Conclusions; Acknowledgments; Chapter Two: Analysis Considerations for Utilizing RNA-Seq to Characterize the Brain Transcriptome; Abstract; 1 Introduction; 2 Defining and Quantifying Transcript/Gene Expression; 3 Detecting Differential Expression; 4 Frameworks for Interpretation; 5 Summary.
- Chapter Three: Data Integration and Reproducibility for High-Throughput TranscriptomicsAbstract; 1 Opportunities for Secondary Use of Data and Meta-Anlaysis in Transcriptomics; 2 Selecting the Unit of Comparison; 3 Metrics for Agreement; 4 Studies on Reproducibility and Validation; 5 Guidelines for Cross-Platform Studies; 6 Other Data Integration Considerations; 7 Summary; Chapter Four: Coexpression and Cosplicing Network Approaches for the Study of Mammalian Brain Transcriptomes; Abstract; 1 Introduction; 2 Construction of Coexpression and Cosplicing Networks.
- 3 Cosplicing Network Construction4 Biological Annotation of Coexpression and Cosplicing Networks; 5 Effects of Genetic Selection on Gene Networks; 6 Module Preservation Across Subpopulations and Species; 7 Module Disruption Related to Behavioral Changes; 8 Summary and Future Directions; Chapter Five: Splicing in the Human Brain; Abstract; 1 Pre-mRNA Splicing in Human Cells; 2 Alternative Pre-mRNA Splicing; 3 Tissue-Specific Alternative Splicing; 4 Alternative Splicing in the Brain; 5 Brain-Specific Splicing Regulation; 6 Transcription-Coupled Regulation of Alternative Splicing.
- 7 Cotranscriptional and Posttranscriptional Splicing8 Global Analysis of Pre-mRNA Splicing; 9 The Influence of RNA Extraction Methods on Transcriptome Analysis; 10 Computational Methods to Study Splicing Dynamics; Chapter Six: Understanding Complex Transcriptome Dynamics in Schizophrenia and Other Neurological Diseases Using RNA Sequencing; Abstract; 1 Introduction; 2 RNA-Seq Studies on Neurological Disorders; 3 Quantifying Transcriptome Dynamics in Neurological Disorders; 4 Discussion and Perspectives; Chapter Seven: The Central Role of Noncoding RNA in the Brain; Abstract; 1 Introduction.
- 2 The Long and Short of Noncoding RNAs3 Types and Function of lncRNAs; 4 RNA Structure; 5 Splicing; 6 NcRNA Editing; 7 Epigenetic Modifications; 8 ncRNAs Are Involved in Neuronal Development, Maintenance, and Plasticity; 9 Evolutionary Role of ncRNAs and Primate Specificity; 10 The Role of (Retro)transposons and Pseudogenes in ncRNA Evolution; 11 ncRNAs and Disease; 12 Perspectives and Outlook; Acknowledgments; Chapter Eight: Genetics of Gene Expression in CNS; Abstract; 1 Introduction; 2 Genetic Resources for eQTL Analysis in Mice; 3 Genetic Mapping Methods; 4 RNA-seq eQTL Studies.