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Molecular biology of B cells /
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understand...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Elsevier Science,
2015.
|
| Edición: | 2nd edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn893332893 | ||
| 003 | OCoLC | ||
| 005 | 20231120111812.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 141018s2015 enka ob 001 0 eng d | ||
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| 020 | |a 9780123984906 |q (electronic bk.) | ||
| 020 | |a 0123984904 |q (electronic bk.) | ||
| 020 | |a 0123979331 | ||
| 020 | |a 9780123979339 | ||
| 020 | |z 9780123979339 | ||
| 035 | |a (OCoLC)893332893 | ||
| 050 | 4 | |a QR185.6 | |
| 060 | 4 | |a Online Book | |
| 072 | 7 | |a HEA |x 039000 |2 bisacsh | |
| 072 | 7 | |a MED |x 014000 |2 bisacsh | |
| 072 | 7 | |a MED |x 022000 |2 bisacsh | |
| 072 | 7 | |a MED |x 112000 |2 bisacsh | |
| 072 | 7 | |a MED |x 045000 |2 bisacsh | |
| 082 | 0 | 4 | |a 616.07 |a 616.0798 |
| 245 | 0 | 0 | |a Molecular biology of B cells / |c edited by Frederick W. Alt, Tasuku Honjo, Andreas Radbruch, Michael Reth. |
| 250 | |a 2nd edition. | ||
| 264 | 1 | |a London : |b Elsevier Science, |c 2015. | |
| 300 | |a 1 online resource (xxiii 563 pages) : |b color illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed on November 6, 2014). | |
| 520 | |a Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with update. | ||
| 505 | 0 | |a Front Cover; Molecular Biology of B Cells; Copyright; Dedication; Contents; Preface; Contributors; Chapter 1 -- The Structure and Regulation of the Immunoglobulin Loci; 1. INTRODUCTION; 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS; 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS; 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION; 6. JUNCTIONAL DIVERSITY; 7. COMBINATORIAL DIVERSITY; 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT. | |
| 505 | 8 | |a 9. THE PROCESS OF DH-JH RECOMBINATION10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 13. CONCLUSION; REFERENCES; Chapter 2 -- The Mechanism of V(D)J Recombination; 1. OVERVIEW; 2. ANTIGEN RECEPTOR GENE ASSEMBLY; 3. RECOMBINATION SIGNAL SEQUENCES; 4. BIOCHEMISTRY OF V(D)J CLEAVAGE; 5. RAG1 AND RAG2; 6. A ROLE FOR HMGB1 IN V(D)J RECOMBINATION; 7. RECOMBINATION COMPLEXES: ANALYSIS OF STOICHIOMETRY AND ORGANIZATION. | |
| 505 | 8 | |a 8. V(D)J RECOMBINATION IS TIGHTLY REGULATED DURING LYMPHOCYTE DEVELOPMENT9. ACCESSIBILITY MODEL OF REGULATION; 10. OVERVIEW OF CHROMATIN STRUCTURE; 11. REGULATION BY NUCLEOSOME STRUCTURE AND HISTONE ACETYLATION; 12. REGULATION BY HISTONE METHYLATION; 13. HOW IS THE CHROMATIN STRUCTURE OF ANTIGEN RECEPTOR LOCI DEVELOPMENTALLY REGULATED?; 14. ADDITIONAL LAYERS OF REGULATION; 15. REGULATION OF V(D)J RECOMBINATION: SUMMARY; 16. ONCOGENIC LESIONS IN LYMPHOID NEOPLASMS: THE PRICE OF A DIVERSE ANTIGEN RECEPTOR REPERTOIRE; 17. PROPOSED MECHANISMS UNDERLYING RAG-MEDIATED GENOMIC LESIONS. | |
| 505 | 8 | |a 18. REGULATORY CONTROLS PROPOSED TO SUPPRESS RAG-MEDIATED GENOMIC INSTABILITY19. V(D)J RECOMBINATION ERRORS AS PATHOGENIC LESIONS IN LYMPHOID NEOPLASMS: SUMMARY; REFERENCES; Chapter 3 -- Transcriptional Regulation of Early B Cell Development; 1. PU. 1 SETS THE STAGE FOR LYMPHOID AND MYELOID DEVELOPMENT; 2. LINEAGE PRIMING IN LYMPHOID PROGENITORS BY IKAROS; 3. E2A REGULATES THE CHROMATIN LANDSCAPE TO PROMOTE GENE EXPRESSION IN B CELL DEVELOPMENT; 4. E2A IS INHIBITED BY ID PROTEINS; 5. INTERLEUKIN-7/STAT5 SIGNALING PROVIDES AN EARLY SIGNAL FOR B CELL LINEAGE SPECIFICATION. | |
| 505 | 8 | |a 6. EARLY B CELL FACTOR: CENTRAL COORDINATOR OF B CELL DEVELOPMENT7. COLLABORATION BETWEEN EBF1 AND FOXO1; 8. REGULATION OF THE B CELL-SPECIFIC PROGRAM BY PAX5; 9. REGULATION OF B LINEAGE COMMITMENT; 10. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; Chapter 4 -- Relationships among B Cell Populations Revealed by Global Gene Analysis; 1. INTRODUCTION; 2. GENE PROFILE CHANGES WITH B CELL MATURATION SUGGEST AN ORDERING OF TRANSITIONAL STAGES; 3. DISTINCTIONS IN GENE NETWORKS ACTIVATED IN MATURE B CELL POPULATIONS. | |
| 650 | 0 | |a Molecular immunology. | |
| 650 | 0 | |a B cells. | |
| 650 | 0 | |a B cells |x Differentiation |x Molecular aspects. | |
| 650 | 0 | |a Immunoglobulins. | |
| 650 | 0 | |a Immunoglobulin genes. | |
| 650 | 1 | 2 | |a B-Lymphocytes |0 (DNLM)D001402 |
| 650 | 1 | 2 | |a Immunoglobulins |0 (DNLM)D007136 |
| 650 | 2 | |a Genes, Immunoglobulin |0 (DNLM)D005803 | |
| 650 | 2 | 2 | |a Cell Differentiation |x physiology |0 (DNLM)D002454Q000502 |
| 650 | 6 | |a Immunologie mol�eculaire. |0 (CaQQLa)201-0203813 | |
| 650 | 6 | |a Lymphocytes B. |0 (CaQQLa)201-0056955 | |
| 650 | 6 | |a Lymphocytes B |x Diff�erenciation |x Aspect mol�eculaire. |0 (CaQQLa)201-0207818 | |
| 650 | 6 | |a G�enes de l'immunoglobuline. |0 (CaQQLa)201-0276999 | |
| 650 | 6 | |a Immunoglobulines. |0 (CaQQLa)201-0008346 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a B cells |2 fast |0 (OCoLC)fst00824789 | |
| 650 | 7 | |a B cells |x Differentiation |x Molecular aspects |2 fast |0 (OCoLC)fst00824791 | |
| 650 | 7 | |a Immunoglobulin genes |2 fast |0 (OCoLC)fst00967959 | |
| 650 | 7 | |a Immunoglobulins |2 fast |0 (OCoLC)fst00967961 | |
| 650 | 7 | |a Molecular immunology |2 fast |0 (OCoLC)fst01024811 | |
| 700 | 1 | |a Honj�o, Tasuku, |e editor. | |
| 700 | 1 | |a Reth, Michael, |e editor. | |
| 700 | 1 | |a Radbruch, A. |q (Andreas), |e editor. | |
| 700 | 1 | |a Alt, Frederick W., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Molecular biology of B cells. |d Boston, Massachusetts : Elsevier, [2015] |z 9780123979339 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123979339 |z Texto completo |