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Methods in neurosciences. alternate approaches / Volume 21, Providing pharmacological access to the brain :
This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Academic Press,
[1994]
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| Colección: | Methods in neurosciences ;
v. 21. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover image; Title page; Table of Contents; Methods in Neurosciences; Copyright page; Contributors to Volume 21; Preface; Methods in Neurosciences; Chapter 1: Cellular Response of Central Nervous System Tissue to Invasive Therapeutic Measures; Publisher Summary; Introduction; Definition of Cellular Response to Injury; Definition of Trophic Mechanisms of Injury Response; Models for Therapeutic Manipulation; Efficacy of Therapeutic Measures; Conclusions; Chapter 2: Models of Angiogenesis and the Blood-Brain Barrier; Publisher Summary; Introduction.
- Techniques for Localization of Proliferating Vasculature (Angiogenesis)Strategies for Determining Temporal Sequence and Source of Neovascularization in Neural Transplants; Techniques to Determine Blood-Brain Barrier Permeability; Acknowledgments; Chapter 3: Osmotic Opening of the Blood-Brain Barrier and Brain Tumor Chemotherapy; Publisher Summary; Introduction; Osmotic Opening of Blood-Brain Barrier; Size Dependence of Blood-Brain Barrier Permeability; Osmotic Opening and Brain Tumor Chemotherapy; Conclusions.
- Chapter 4: Osmotic Blood
- Brain Barrier Modification: Increasing Delivery of Diagnostic and Therapeutic Agents to the BrainPublisher Summary; Introduction; Blood-Brain Barrier; Blood-Brain Barrier Disruption; Development of Animal Models; Confirming Blood-Brain Barrier Disruption; Factors Influencing Successful Blood-Brain Barrier Disruption and Agent Delivery; Conclusion; Chapter 5: Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants; Publisher Summary; Introduction.
- Methods and ResultsConcluding Remarks; Acknowledgments; Chapter 6: Ferrotransferrin and Antibody against the Transferrin Receptor as Potential Vehicles for Drug Delivery across the Mammalian Blood-Brain Barrier into the Central Nervous System; Publisher Summary; Introduction; Iron, Transferrin, and Transferrin Receptor; Preparation and Application of Ferrotransferrin and Antibody against the Ferrotransferrin Receptor; Analyses of Potential Transcytosis of Blood-Borne, Receptor-Mediated Probe Molecules across the Blood-Brain Barrier.
- Transendothelial Pathways for Ferrotransferrin and Antibody against the Ferrotransferrin Receptor as Vehicles for Circumventing the Blood-Brain BarrierSummary and Conclusions; Acknowledgments; Chapter 7: DepoFoam-Mediated Drug Delivery into Cerebrospinal Fluid; Publisher Summary; Introduction; Synthesis of DepoFoam-Encapsulated Ara-C (DTC 101); Preparation of DepoFoam-Encapsulated Methotrexate (Depo/MTX); Preparation of Depo/Morphine; Synthesis of Depo/IFN; Central Nervous System Pharmacokinetic Analysis; Intraventricular Pharmacokinetics of DTC 101 in Rats.