Biophysical characterization of proteins in developing biopharmaceuticals /

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Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Houde, Damian J. (Editor ), Berkowitz, Steven A. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands : Elsevier, 2015.
Temas:
Biopharmaceutics.
Pharmaceutical technology.
Proteins > analysis
Biopharmaceutics
Technology, Pharmaceutical
Biopharmacie.
Techniques pharmaceutiques.
MEDICAL > Pharmacology.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Biophysical Characterization of Proteins in Developing Biopharmaceuticals; Copyright; Contents; List of Contributors; About the Editors; Preface; List of Abbreviations and Symbols; Chapter 1
  • The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals; 1.1 THE BASICS OF PROTEIN HIGHER-ORDER STRUCTURE (HOS); 1.2 THE SEARCH FOR HOW PROTEINS ATTAIN THEIR CORRECT HOS: THE PROTEIN FOLDING PROBLEM; 1.3 SURPRISES IN THE WORLD OF PROTEIN FOLDING: INTRINSICALLY DISORDERED OR UNSTRUCTURED PROTEINS (AN APPARENT CHALLENGE TO THE ...
  • 1.4 PROTEINS AND THE BIOPHARMACEUTICAL INDUSTRY: PROBLEMS AND CHALLENGES1.5 CONCLUSION; References; Further Reading; Chapter 2
  • Biophysical Characterization and Its Role in the Biopharmaceutical Industry; 2.1 DRUG DEVELOPMENT PROCESS; 2.2 PROTEIN DRUGS (BIOPHARMACEUTICALS); 2.3 THE ROLE OF BIOPHYSICAL CHARACTERIZATION IN BIOPHARMACEUTICAL DRUG DEVELOPMENT; 2.4 THE CHALLENGES IN CONDUCTING BIOPHYSICAL MEASUREMENTS TO DETECT CHANGES IN A PROTEIN DRUG''S HOS; 2.5 REGULATORY NEEDS AND CONSIDERATIONS; References; Further Reading; Chapter 3
  • Biopharmaceutical Industry''s Biophysical Toolbox.
  • 3.1 ATTRIBUTES OF A SINGLE BIOPHYSICAL TOOL TO CHARACTERIZE AND DETECT CHANGES IN THE HIGHER ORDER STRUCTURE OF A BIOPHARMACEUTICAL3.2 STUDYING THE BIOPHYSICAL PROPERTIES OF A BIOPHARMACEUTICAL AS AN INDIRECT APPROACH FOR CHARACTERIZING CHANGES IN ITS HOS; 3.3 GENERAL CONSIDERATIONS IN ANALYZING THE BIOPHYSICAL PROPERTIES OF BIOPHARMACEUTICALS; 3.4 THE UTILITY OF USING STRESS TO MONITOR CHANGES IN THE HOS PROFILE OF A PROTEIN DRUG; 3.5 PRESENT BIOPHYSICAL TOOLBOX; 3.6 CONCLUSION; References; Further Reading.
  • Chapter 4
  • An Introduction and Hierarchical Organization of the Biophysical Tool in Section II4.1 INTRODUCTION; 4.2 THE STANDARD CLASS OF BIOPHYSICAL TOOLS USED IN THE BIOPHARMACEUTICAL INDUSTRY; 4.3 THE ADVANCED CLASS OF BIOPHYSICAL TOOLS USED IN THE BIOPHARMACEUTICAL INDUSTRY; 4.4 AN OVERVIEW OF SECTION II; References; Further Reading; Chapter 5
  • The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development; 5.1 INTRODUCTION; 5.2 THE ORIGINS OF ELECTRONIC ABSORPTION, FLUORESCENCE, AND FT-IR SPECTROSCOPY; 5.3 CONFORMATIONAL ANALYSIS OF PROTEINS IN SOLUTION.
  • 5.4 OPTICAL SPECTROSCOPY AND PRODUCT COMPARABILITY5.5 OPTICAL SPECTROSCOPY AND HIGH-THROUGHPUT METHODS; 5.6 SOLID-STATE MEASUREMENTS; 5.7 CONCLUSIONS; References; Chapter 6
  • Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical Applications; 6.1 INTRODUCTION; 6.2 INSTRUMENTATION; 6.3 DATA GENERATED; 6.4 GUIDE TO COLLECTING GOOD DATA; 6.5 DATA PROCESSING AND ANALYSES; 6.6 ROLE IN THE RESEARCH INDUSTRY; 6.7 TECHNOLOGY AVAILABILITY; 6.8 FUTURE DEVELOPMENTS; Acknowledgments; References; Further Reading.
  • Chapter 7
  • Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development.

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